{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:44:57Z","timestamp":1784756697417,"version":"3.55.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"Hang Tuah University-Internal Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0420_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Echinometra mathaei<\/jats:italic>\n                      was known to have potential antioxidant activities because it contains of\u00a0\n                      <jats:italic>polyhydroxy-naphthoquinone<\/jats:italic>\n                      (\n                      <jats:italic>echinochrome<\/jats:italic>\n                      and\n                      <jats:italic>spinochromes<\/jats:italic>\n                      ). The antioxidant properties contributed to the hepatoprotective effect by binding to free radicals compound that causes oxidative stress and necrosis in the\u00a0hepatocytes. The research aimed to determine the hepatorepair effects of the\n                      <jats:italic>E.\u00a0mathaei<\/jats:italic>\n                      ethanol extract on\u00a0high-dose paracetamol-induced hepatic damage in Wistar rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0420_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This research used a true experimental method. Thirty white male rats were divided into sixth groups, i.e.,\u00a0normal control group, group II\u2013VI was induced paracetamol 2,000\u00a0mg\/kg BW for three days. After paracetamol-induced, group III\u2013VI was treated with curcumin 800\u00a0mg\/kg BW,\n                      <jats:italic>E.\u00a0mathaei<\/jats:italic>\n                      extract 400, 800, and 1,200\u00a0mg\/kg BW for seven days. The hepatorepair parameter was obtained from AST\/ALT, MDA tissue levels, and the number of hepatocyte necrosis cells. The data results were analyzed using the ANOVA test, followed by the LSD test to determine the difference between each treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0420_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that\n                      <jats:italic>E.\u00a0mathaei<\/jats:italic>\n                      significantly (p&lt;0.05) decreased the AST levels, MDA levels and the number of hepatocyte necrosis cells at a dose of 800\u00a0mg\/kg BW per orally treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0420_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>The E. mathaei<\/jats:italic>\n                      ethanol extract repaired the hepatic damage induced by paracetamol.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0420","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T12:45:59Z","timestamp":1625229959000},"page":"511-516","source":"Crossref","is-referenced-by-count":9,"title":["AST\/ALT levels, MDA, and liver histopathology of\u00a0\n                    <i>Echinometra mathaei<\/i>\n                    ethanol extract on paracetamol-induced hepatotoxicity in rats"],"prefix":"10.1515","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-6767","authenticated-orcid":false,"given":"Angelica","family":"Kresnamurti","sequence":"first","affiliation":[{"name":"Pharmacy Study Program , Faculty of Medicine, Hang Tuah University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dita Nurlita","family":"Rakhma","sequence":"additional","affiliation":[{"name":"Pharmacy Study Program , Faculty of Medicine, Hang Tuah University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitasari","family":"Damayanti","sequence":"additional","affiliation":[{"name":"Pharmacy Study Program , Faculty of Medicine, Hang Tuah University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Septiyan Dwi","family":"Santoso","sequence":"additional","affiliation":[{"name":"Pharmacy Study Program , Faculty of Medicine, Hang Tuah University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enggar","family":"Restryarto","sequence":"additional","affiliation":[{"name":"Pharmacy Study Program , Faculty of Medicine, Hang Tuah University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wifqi","family":"Hadinata","sequence":"additional","affiliation":[{"name":"Pharmacy Study Program , Faculty of Medicine, Hang Tuah University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwan Sahrial","family":"Hamid","sequence":"additional","affiliation":[{"name":"Pharmacology , Faculty of Veterinary Medicine, Airlangga University , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"2025121209024965539_j_jbcpp-2020-0420_ref_001","doi-asserted-by":"crossref","unstructured":"Mahmoodzadeh, Y, Mazani, M, Rezagholizadeh, L. 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