{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:10:05Z","timestamp":1779916205880,"version":"3.53.1"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"PT. Paragon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0510_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Batik dyes contain irritant chemicals that increase the risk of skin barrier disruption. This study aims to determine the effect of\n                      <jats:italic>Centella asiatica<\/jats:italic>\n                      and ceramide in transepidermal water loss (TEWL), hydration of the stratum corneum and skin acidity (pH).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0510_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a double blind clinical trial of 30 Indonesian batik workers who suffered from skin dryness, but had no clinical manifestation of contact dermatitis. Subjects were given cream containing\n                      <jats:italic>C. asiatica<\/jats:italic>\n                      or ceramide that formulated and randomly labeled by manufacturer (PT Paragon Technology and Innovation). Both subjects and researchers were blinded to the type of the cream. Cream was applied to the hands and arms twice a day. Biological function of the skin (TEWL, stratum corneum hydration level, and skin acidity) was examined by Cutometer dual MP-580. Baseline was recorded in the first examination, followed by second and third examinations at two and four weeks after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0510_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After four weeks treatment, there were significant improvement of\n                      <jats:italic>C. asiatica<\/jats:italic>\n                      application in evaluation of corneometer palmar (p=0.007; CI 95%), corneometer dorsum (p=0.001; CI 95%), and skin acidity dorsum (p=0.017; CI 95%). Ceramide application also gave significant improvement of corneometer palmar (0.038; CI 95%), skin acidity palmar (p=0.001; CI 95%), TEWL dorsum (p=0.023; CI 95%), corneometer dorsum (p=0.002; CI 95%) and skin acidity dorsum (p=0.011; CI 95%). There were no significant differences of\n                      <jats:italic>C. asiatica<\/jats:italic>\n                      effectiveness compared to ceramide in skin barrier improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0510_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>C. asiatica<\/jats:italic>\n                      and ceramide can improve skin barrier hydration in order to prevent the risk of contact dermatitis in batik workers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0510","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T14:31:11Z","timestamp":1625236271000},"page":"589-593","source":"Crossref","is-referenced-by-count":8,"title":["Role of\n                    <i>Centella asiatica<\/i>\n                    and ceramide in skin barrier improvement: a double blind clinical trial of Indonesian batik workers"],"prefix":"10.1515","volume":"32","author":[{"given":"Sylvia","family":"Anggraeni","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine , Universitas Airlangga\/Dr. Soetomo General Academic Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menul Ayu","family":"Umborowati","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine , Universitas Airlangga\/Dr. Soetomo General Academic Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damayanti","family":"Damayanti","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine , Universitas Airlangga\/Dr. Soetomo General Academic Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anang","family":"Endaryanto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine , Universitas Airlangga\/Dr. Soetomo General Academic Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cita Rosita Sigit","family":"Prakoeswa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine , Universitas Airlangga\/Dr. Soetomo General Academic Hospital , Surabaya , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"2025121208571243266_j_jbcpp-2020-0510_ref_001","unstructured":"Tresnadi, C, Sachari, A. 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Skin Res Technol 2002;8:178\u201386. https:\/\/doi.org\/10.1034\/j.1600-0846.2002.10342.x.","DOI":"10.1034\/j.1600-0846.2002.10342.x"},{"key":"2025121208571243266_j_jbcpp-2020-0510_ref_013","doi-asserted-by":"crossref","unstructured":"George, M, Joseph, L, Ramaswamy. Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts. Afr J Trad Complement Altern Med 2009;6:554\u20139. https:\/\/doi.org\/10.4314\/ajtcam.v6i4.57206.","DOI":"10.4314\/ajtcam.v6i4.57206"},{"key":"2025121208571243266_j_jbcpp-2020-0510_ref_014","doi-asserted-by":"crossref","unstructured":"Coderch, L, L\u00f3pez, O, De La Maza, A, Parra, JL. Ceramides and skin function. Am J Clin Dermatol 2003;4:107\u201329. https:\/\/doi.org\/10.2165\/00128071-200304020-00004.","DOI":"10.2165\/00128071-200304020-00004"},{"key":"2025121208571243266_j_jbcpp-2020-0510_ref_015","doi-asserted-by":"crossref","unstructured":"Sethi, A, Kaur, T, Malhotra, SK, Gambhir, ML. Moisturizers: the slippery road. 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