{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:49:25Z","timestamp":1782773365939,"version":"3.54.5"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"3","funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["981611"],"award-info":[{"award-number":["981611"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2022-0159_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute renal injury (AKI) is a major limiting factor for cisplatin administration. Recent evidence suggests the potential contribution of mesenchymal stem cells (MSCs) to rehabilitation from several disorders via both direct and indirect routes. Thus, the present study aimed, for the first time, to explore and compare the reno-protective potential of human dental pulp-derived stem cells (hDPSCs) vs. hDPSC-conditioned medium (hDPSC-CM) in recovery of impaired kidney tissues in a rat animal model of cisplatin-induced AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2022-0159_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>AKI was induced via cisplatin injection (n=36). One day after, 24 rats were treated with either hDPSCs or hDPSC-CM (n=12). An extra set of rats (n=12) served as sham group. On days 2 or 7 (n=6), rats were humanly sacrificed for further analysis. Renal injury was explored via measuring serum creatinine and BUN. Renal level of oxidative stress was assessed by determining malondialdehyde, and enzymatic activities of superoxide dismutase and catalase. Renal histopathological changes were scored for comparison among different experimental groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2022-0159_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A single dose of cisplatin resulted in considerable renal dysfunction and oxidative stress. Treatment with hDPSCs or hDPSC-CM resulted in significantly restored renal function, reduced level of oxidative stress, and improved histopathological manifestations. Furthermore, as compared to hDPSC-CM, administration of hDPSCs led to superior results in AKI-induced animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2022-0159_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current study described the first comparative evidence of reno-protective potential of hDPSCs and their CM against cisplatin-induced nephrotoxicity in an AKI rat model, proposing them as useful adjunctive therapy in AKI. Yet, future explorations are still needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2022-0159","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T15:02:30Z","timestamp":1665068550000},"page":"349-356","source":"Crossref","is-referenced-by-count":7,"title":["Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes"],"prefix":"10.1515","volume":"34","author":[{"given":"Esmail","family":"Ranjbar","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalil","family":"Tavakol Afshari","sequence":"additional","affiliation":[{"name":"Immunology Research Center, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"KhajaviRad","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ebrahimzadeh-Bideskan","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran"},{"name":"Applied Biomedical Research Center , Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2557-3895","authenticated-orcid":false,"given":"Reyhaneh","family":"Shafieian","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, School of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran"},{"name":"Stem Cell and Regenerative Medicine Research Center , Mashhad University of Medical Sciences , Mashhad , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"2025121209125774804_j_jbcpp-2022-0159_ref_001","doi-asserted-by":"crossref","unstructured":"Gaibi, T, Ghatak-Roy, A. 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