{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:06:27Z","timestamp":1770271587557,"version":"3.49.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2023-0165_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>An increasing number of COVID\u201319 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 patients requiring CPAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2023-0165_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a single center, prospective, randomized clinical study. Sixty-three COVID-19 patients with hypoxemic respiratory failure and bilateral pneumonia were randomized in two Groups: Group A received CPAP with fixed PEEP of 10\u202fcm H\n                      <jats:sub>2<\/jats:sub>\n                      O, Group B performed the \u201cPEEP trial\u201d, that consists in the evaluation of best PEEP defined as the PEEP value that precedes the echographic appearance of \u201clung pulse\u201d determining a PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      increase. Primary outcome was composite in-hospital mortality\u00a0+\u00a0intubation, secondary outcome was the percentage increase of PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      . As safety indicator, the incidence of pneumothorax was collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2023-0165_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-two patients were enrolled in\n                      <jats:bold>Group A<\/jats:bold>\n                      and 31 in\n                      <jats:bold>Group B<\/jats:bold>\n                      . The two groups were comparable for clinical characteristics and laboratory parameters. The primary outcome occurred in 36 (57.1\u202f%) patients: 23 (71.8\u202f%) in\n                      <jats:bold>Group A<\/jats:bold>\n                      and 13 (41.9\u202f%) in\n                      <jats:bold>Group B<\/jats:bold>\n                      (p&lt;0.01). Mortality was higher in\n                      <jats:bold>Group A<\/jats:bold>\n                      (53.1 vs. 19.3\u202f%, p&lt;0.01), while intubation rate was comparable between groups.\n                      <jats:bold>Group B<\/jats:bold>\n                      showed a higher PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      increase than\n                      <jats:bold>Group A<\/jats:bold>\n                      (34.9 vs. 13.1\u202f%, p&lt;0.01). Five cases of pneumothorax were reported in\n                      <jats:bold>Group A<\/jats:bold>\n                      , none in\n                      <jats:bold>Group B<\/jats:bold>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2023-0165_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lung ultrasound-guided PEEP trial is associated with lower mortality in COVID-19 patients treated with CPAP. Identifying the best PEEP is useful to increase oxygenation and reduce the incidence of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2023-0165","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T14:40:28Z","timestamp":1689691228000},"page":"677-682","source":"Crossref","is-referenced-by-count":3,"title":["Lung ultrasound-guided PEEP titration in COVID\u201319 patients treated with CPAP"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-8343","authenticated-orcid":false,"given":"Giorgio","family":"Bosso","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Sansone","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Papillo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Giaquinto","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Orefice","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Allegorico","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Serra","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Minerva","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Mercurio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences , Federico II University , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cannavacciuolo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , AORN San Giuseppe Moscati , Avellino , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Dello Vicario","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Giuliano","family":"Numis","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, COVID Care Unit , Santa Maria delle Grazie Hospital , Pozzuoli , Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"2025121209164163088_j_jbcpp-2023-0165_ref_001","doi-asserted-by":"crossref","unstructured":"Navas-Blanco, JR, Dudaryk, R. 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