{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T02:43:06Z","timestamp":1776912186066,"version":"3.51.2"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"4-5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2024-0018_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Vitamin D is essential for maintaining bone and mineral balance. This study aims to identify the most effective route for achieving optimal vitamin D levels (\u226530\u202fng\/mL) to support bone and mineral health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2024-0018_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open-label randomized trial, 132 participants aged 18\u201360 with initial serum vitamin D levels below 30\u202fng\/mL were divided into three intervention groups: daily 800\u202fI.U. oral tablet (Group A), weekly 60,000\u202fI.U. oral sachet (Group B), and monthly 300,000\u202fI.U. intramuscular injection (Group C). The study assessed changes in their serum vitamin D levels at six and 12\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2024-0018_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The monthly intramuscular (IM) group consistently had the highest mean vitamin D levels at six weeks 38.38(\u00b19.953) (p&lt;0.002) and 12\u00a0weeks 48.15(\u00b17.71) (p&lt;0.001). Vitamin D insufficiency was reduced to 34.8\u202f% at six weeks (p=0.434) and 6.8\u202f% at 12\u00a0weeks (p=0.002). Notably, 100\u202f% of the monthly IM group achieved vitamin D sufficiency at 12\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2024-0018_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The monthly IM route demonstrated superior effectiveness compared to tablets and sachets at both the 6-week and 12-week points. A significantly larger number of monthly IM participants achieved vitamin D sufficiency compared to the other groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2024-0018","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:56:04Z","timestamp":1724115364000},"page":"295-304","source":"Crossref","is-referenced-by-count":2,"title":["Oral vs. injected: which vitamin D boost works best for low levels?"],"prefix":"10.1515","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5766-3807","authenticated-orcid":false,"given":"Neha","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pharmacology , 442340 All India Institute of Medical Sciences Patna , Patna , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-6674","authenticated-orcid":false,"given":"Pallavi","family":"Lohani","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Hitech Medical College , Rourkela , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-4686","authenticated-orcid":false,"given":"Shruti","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , 442340 All India Institute of Medical Sciences Patna , Patna , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"2025121209192468080_j_jbcpp-2024-0018_ref_001","doi-asserted-by":"crossref","unstructured":"Berger, MM, Shenkin, A, Schweinlin, A, Amrein, K, Augsburger, M, Biesalski, HK, et al.. 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