{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:15:21Z","timestamp":1765541721106,"version":"3.48.0"},"reference-count":56,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"DOI":"10.13039\/501100008091","name":"Golestan University of Medical Sciences","doi-asserted-by":"publisher","award":["112822"],"award-info":[{"award-number":["112822"]}],"id":[{"id":"10.13039\/501100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2024-0060_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Numerous studies show that the adipokines play a role in on the thyroid axis. The aim of this study was the evaluation of serum level of CTRP-3 and CTRP-6 as a member of the adipokines family in patients with Hashimoto\u2019s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2024-0060_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The levels of CTRP-3 and CTRP-6 were evaluated with enzyme-linked immunosorbent assay in 70 subjects (35 newly diagnosed Hashimoto\u2019s thyroiditis and 35 healthy subjects). Their relationship with the thyroid hormone and some biochemical factors was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2024-0060_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The levels of CTRP3 and CTRP6 in patients with Hashimoto\u2019s disease were higher than those in the control group (p&lt;0.05). There was a significant positive correlation between CTRP3 and TSH levels (r=0.286 and p=0.017). There was a significant relationship between CTRP3 and Fasting Blood Sugar (r=0.249 and p=0.038). There was a significant inverse negative correlation between CTRP6 levels and T3 (r=\u22120.269 and p=0.024), and T4 (r=\u22120.272 and p=0.023). Moreover, there was a significant positive correlation between CTRP6 serum levels and TSH serum levels (r=0.397 and p=0.001). There was a significant positive correlation between CTRP6 levels and Cholesterol (r=0.351 and p=0.003), and LDL (r=\u22120.244 and p=0.042).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2024-0060_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Finally, our results demonstrated that serum levels of CTRP3 and CTRP6 are higher in patients with Hashimoto\u2019s compared to the control group and probably play a role in the pathogenesis of Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2024-0060","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T21:10:29Z","timestamp":1737407429000},"page":"61-67","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the serum level of CTRP-3 and CTRP-6 in patients with Hashimoto\u2019s disease and correlation with thyroid hormones and lipid profile"],"prefix":"10.1515","volume":"36","author":[{"given":"Rafal Sameer","family":"Al-Abboody","sequence":"first","affiliation":[{"name":"Metabolic Disorders Research Center , 125691 Golestan University of Medical Sciences , Gorgan , Iran"},{"name":"Department of Biochemistry and Biophysics, Faculty of Medicine , 125691 Golestan University of Medical Sciences , Gorgan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Heydari","sequence":"additional","affiliation":[{"name":"Metabolic Disorders Research Center , 125691 Golestan University of Medical Sciences , Gorgan , Iran"},{"name":"Department of Biochemistry and Biophysics, Faculty of Medicine , 125691 Golestan University of Medical Sciences , Gorgan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Saravani","sequence":"additional","affiliation":[{"name":"Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Nosaratzehi","sequence":"additional","affiliation":[{"name":"Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences , Zahedan , Iran"},{"name":"Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences , Zahedan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh","family":"Akbari","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit , Sayad Shirazi Hospital, Golestan University of Medical Science , Gorgan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-7505","authenticated-orcid":false,"given":"Seyyed Mehdi","family":"Jafari","sequence":"additional","affiliation":[{"name":"Metabolic Disorders Research Center , 125691 Golestan University of Medical Sciences , Gorgan , Iran"},{"name":"Department of Biochemistry and Biophysics, Faculty of Medicine , 125691 Golestan University of Medical Sciences , Gorgan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"2025121209195692222_j_jbcpp-2024-0060_ref_001","doi-asserted-by":"crossref","unstructured":"Casto, C, Pepe, G, Li Pomi, A, Corica, D, Aversa, T, Wasniewska, M. 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