{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:07:05Z","timestamp":1789092425157,"version":"build-2803163510"},"reference-count":69,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tendons are vital components of the musculoskeletal system, facilitating movement and supporting mechanical loads. Emerging evidence suggests that vitamin D, beyond its well-established role in bone health, exerts significant effects on tendon physiology. The aim of this manuscript is to review the impact of vitamin D on tendons, focusing on its mechanisms of action, clinical implications, and therapeutic applications. A comprehensive search of scientific electronic databases was conducted to identify articles on the effects of vitamin D on\u00a0tendon health. Fourteen studies were included in this review. Five studies were performed\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    , and nine studies were conducted\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    . Despite some conflicting results, the included studies showed that vitamin D regulates collagen synthesis, inflammation, and mineralization within tendons through its interaction with vitamin D receptors. Epidemiological studies link vitamin D deficiency with tendon disorders, including tendinopathy and impaired healing. Supplementation with vitamin D shows promise in improving tendon strength and function, particularly in at-risk populations such as athletes and the elderly. Future research should address optimal supplementation strategies and explore the interplay between vitamin D and other factors influencing tendon health. Integrating vitamin D optimization into clinical practice could enhance tendon integrity and reduce the burden of tendon-related pathologies.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2024-0061","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T07:00:00Z","timestamp":1716361200000},"page":"143-152","source":"Crossref","is-referenced-by-count":16,"title":["Exploring the impact of vitamin D on tendon health: a comprehensive review"],"prefix":"10.1515","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-9568","authenticated-orcid":false,"given":"Domiziano","family":"Tarantino","sequence":"first","affiliation":[{"name":"Department of Public Health , 9307 University of Naples Federico II , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita","family":"Mottola","sequence":"additional","affiliation":[{"name":"Department of Public Health , 9307 University of Naples Federico II , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Sirico","sequence":"additional","affiliation":[{"name":"Department of Public Health , 9307 University of Naples Federico II , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Corrado","sequence":"additional","affiliation":[{"name":"Department of Public Health , 9307 University of Naples Federico II , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ruosi","sequence":"additional","affiliation":[{"name":"Department of Public Health , 9307 University of Naples Federico II , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Saggini","sequence":"additional","affiliation":[{"name":"Faculty of Psychology , 471917 eCampus University , Novedrate , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaello","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Scientific Research , Campus Ludes, Off-Campus Semmelweis University , Lugano , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"2025121209194873720_j_jbcpp-2024-0061_ref_001","doi-asserted-by":"crossref","unstructured":"Aicale, R, Tarantino, D, Maffulli, N. 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Autograft reconstruction for chronic Achilles tendon disorders. Tech Foot Ankle Surg 2017;16:117. https:\/\/doi.org\/10.1097\/BTF.0000000000000154.","DOI":"10.1097\/BTF.0000000000000154"},{"key":"2025121209194873720_j_jbcpp-2024-0061_ref_016","doi-asserted-by":"crossref","unstructured":"Pellegrino, R, Brindisino, F, Barassi, G, Sparvieri, E, DI Iorio, A, de Sire, A, et al.. Combined ultrasound guided peritendinous hyaluronic acid (500\u2013730 Kda) injection with extracorporeal shock waves therapy vs. extracorporeal shock waves therapy-only in the treatment of shoulder pain due to rotator cuff tendinopathy. A randomized clinical trial. J Sports Med Phys Fitness 2022;62:1211\u20138. https:\/\/doi.org\/10.23736\/S0022-4707.22.13924-1.","DOI":"10.23736\/S0022-4707.22.13924-1"},{"key":"2025121209194873720_j_jbcpp-2024-0061_ref_017","doi-asserted-by":"crossref","unstructured":"Riley, GP, Curry, V, DeGroot, J, van El, B, Verzijl, N, Hazleman, BL, et al.. 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