{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:48:55Z","timestamp":1769813335928,"version":"3.49.0"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2025-0041_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study compared urine output at 2 and 6 h post-furosemide and explored factors influencing diuretic efficacy in acute heart failure (AHF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2025-0041_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study (June\u2013August 2023) included AHF patients (\u226518\u202fyears) with NT-proBNP\u00a0\u2265300\u202fpg\/mL. Urinary spot sodium and urine output were measured at baseline, 2, and 6\u202fh after 40\u202fmg IV furosemide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2025-0041_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 32 patients, 26 (81.25\u202f%) had satisfactory urine output, and 30 (93.75\u202f%) met the target urinary sodium concentration at 2\u202fh. No significant difference in mean urine output was found between the 2 and 6\u202fh intervals (267\u00a0\u00b1\u00a0189\u202fmL vs. 298\u00a0\u00b1\u00a0149\u202fmL, p=0.099). Urine output correlated strongly with urinary sodium concentration (p\u00a0&lt;\u00a00.001, R\n                      <jats:sup>2<\/jats:sup>\n                      =0.683). Serum creatinine was a significant predictor of urine output (p=0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2025-0041_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The comparable urine output at 2 and 6\u202fh suggests that a 2\u202fh assessment may be sufficient to evaluate diuretic response and guide dose adjustments in\u00a0AHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2025-0041","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:57:01Z","timestamp":1769101021000},"page":"57-62","source":"Crossref","is-referenced-by-count":0,"title":["Two hours of urine output are a reliable parameter for intravenous furosemide adequacy and the need for doubling dose in acute heart failure: a prospective study"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-6850","authenticated-orcid":false,"given":"Mochamad Y.","family":"Alsagaff","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine , Universitas Airlangga\u2014Dr. Soetomo General Hospital , Surabaya , Indonesia"},{"name":"Universitas Airlangga Hospital , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-9487","authenticated-orcid":false,"given":"Hendri","family":"Susilo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine , Universitas Airlangga\u2014Dr. Soetomo General Hospital , Surabaya , Indonesia"},{"name":"Universitas Airlangga Hospital , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-169X","authenticated-orcid":false,"given":"Christian","family":"Pramudia","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine , Universitas Airlangga\u2014Dr. Soetomo General Hospital , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-4373","authenticated-orcid":false,"given":"Louisa F. K.","family":"Wardhani","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine , Universitas Airlangga\u2014Dr. Soetomo General Hospital , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-216X","authenticated-orcid":false,"given":"Irma","family":"Maghfirah","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine , Universitas Airlangga\u2014Dr. Soetomo General Hospital , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-8149","authenticated-orcid":false,"given":"Yusuf","family":"Azmi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine , Universitas Airlangga\u2014Dr. Soetomo General Hospital , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieka N. D.","family":"Anggraeni","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy , Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5715-738X","authenticated-orcid":false,"given":"Wenny P.","family":"Nilamsari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy , Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-3561","authenticated-orcid":false,"given":"Dinda M.","family":"Nusantara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy , Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"2026013012042189358_j_jbcpp-2025-0041_ref_001","doi-asserted-by":"crossref","unstructured":"McDonagh, TA, Metra, M, Adamo, M, Gardner, RS, Baumbach, A, B\u00f6hm, M, et al.. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European society of cardiology (ESC) with the special contribution of the heart failure association (HFA) of the ESC. 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