{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:43:27Z","timestamp":1793832207870,"version":"4.6.1"},"reference-count":70,"publisher":"Walter de Gruyter GmbH","issue":"2-3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2025-0049_abs_001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Male infertility is a critical global health issue, with environmental and occupational exposure to heavy metals, such as lead (Pb), cadmium (Cd), mercury (Hg), and arsenic (As), impacting male reproductive health. This scoping review aims to evaluate the effects of heavy metal exposure on semen parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2025-0049_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>This study adhered to the 2020 PRISMA framework. A broad literature search was performed on January 2025, using Embase, PUBMED, and Scopus. A comprehensive literature search was performed using PubMed, Embase, and Scopus on January 12, 2025, using a combination of Medical Subject terms and keywords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2025-0049_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Of the 1,709 identified studies, 21 met the inclusion criteria and were analyzed. Findings indicate that lead exposure negatively impacts sperm concentration, motility, and morphology, primarily through oxidative stress and enzymatic inhibition. Cadmium disrupts the blood-testis barrier and acrosomal function, leading to sperm abnormalities. Arsenic exposure is linked to oxidative stress, apoptosis, and impaired sperm motility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2025-0049_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>The cumulative evidence supports a strong association between heavy metal exposure and male infertility. This review underscores the need for stricter occupational safety regulations and environmental policies to mitigate heavy metal exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2025-0049","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T05:10:41Z","timestamp":1745212241000},"page":"129-137","source":"Crossref","is-referenced-by-count":18,"title":["The impact of heavy metals exposure on male fertility: a scoping review of human studies"],"prefix":"10.1515","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-4011","authenticated-orcid":false,"given":"Carlo","family":"Giulioni","sequence":"first","affiliation":[{"name":"Department of Urology , Casa di Cura Villa Igea , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Falsetti","sequence":"additional","affiliation":[{"name":"Urology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology , University of Bari \u201cAldo Moro\u201d , Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Maurizi","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit Jesi , Jesi , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences , Policlinico \u201cUmberto I\u201d Hospital, University of Rome \u201cLa Sapienza\u201d , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Crocetto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive Sciences and Odontostomatology , University of Naples \u201cFederico II\u201d , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Imbimbo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Reproductive Sciences and Odontostomatology , University of Naples \u201cFederico II\u201d , Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Cafarelli","sequence":"additional","affiliation":[{"name":"Department of Urology , Casa di Cura Villa Igea , Ancona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"2025121209195971896_j_jbcpp-2025-0049_ref_001","doi-asserted-by":"crossref","unstructured":"Agarwal, A, Farkouh, A, Saleh, R, Abdel-Meguid Hamoda, TA, Harraz, AM, Kavoussi, P, et al.. 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Is cadmium chloride-induced inter-sertoli tight junction permeability barrier disruption a suitable in\u00a0vitro model to study the events of junction disassembly during spermatogenesis in the rat testis? Endocrinology 2001;142:1878\u201388. https:\/\/doi.org\/10.1210\/endo.142.5.8145.","DOI":"10.1210\/en.142.5.1878"},{"key":"2025121209195971896_j_jbcpp-2025-0049_ref_041","unstructured":"ATSDR. Agency for toxic substances and disease registry. Atlanta, GA: U.S. Department of Health and Human Services; 2007. The 2007 CERCLA priority list of hazardous substances."},{"key":"2025121209195971896_j_jbcpp-2025-0049_ref_042","doi-asserted-by":"crossref","unstructured":"Siu, MK, Mruk, DD, Lee, WM, Cheng, CY. Adhering junction dynamics in the testis are regulated by an interplay of beta 1-integrin and focal adhesion complex-associated proteins. 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