{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:20Z","timestamp":1790337800897,"version":"4.1.0"},"reference-count":72,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2026-0031_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Proper cardiac function depends on adequate supply and metabolism of energy substrates. Aluminum chloride exposure has been linked to adverse cardiac events. This study investigated the ameliorative effect of ferulic acid and ascorbic acid in dysregulated cardiac energy metabolism in aluminum chloride-exposed\u00a0mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0031_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty mice were randomized into five groups (n=6): control (0.1\u202f% distilled water), aluminum chloride (AlCl\n                      <jats:sub>3<\/jats:sub>\n                      , 100\u202fmg\/kg,\n                      <jats:italic>p.o<\/jats:italic>\n                      ), aluminum chloride and ferulic acid (AlCl\n                      <jats:sub>3<\/jats:sub>\n                      , 100\u202fmg\/kg; FA\n                      <jats:sub>20<\/jats:sub>\n                      , 10\u202fmg\/kg,\n                      <jats:italic>p.o<\/jats:italic>\n                      ), aluminum chloride and ferulic acid (AlCl\n                      <jats:sub>3<\/jats:sub>\n                      , 100\u202fmg\/kg; FA\n                      <jats:sub>10<\/jats:sub>\n                      , 10\u202fmg\/kg,\n                      <jats:italic>p.o<\/jats:italic>\n                      ), aluminum chloride and ascorbic acid (AlCl\n                      <jats:sub>3<\/jats:sub>\n                      , 100\u202fmg\/kg; Vit. C, 100\u202fmg\/kg), daily for 7\u00a0days. Cardiac metabolic enzymes activities were analyzed spectrophotometrically; substrate transporters and regulators of energy metabolism were analyzed using immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0031_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AlCl\n                      <jats:sub>3<\/jats:sub>\n                      increased hexokinase activity and reduced pyruvate-dehydrogenase activity compared with the control. AlCl\n                      <jats:sub>3<\/jats:sub>\n                      significantly reduced the expression of glucose transporter-4 (GLUT 4), carnitine palmitoyl-transferase 1\u03b2 (CPT1\u03b2), peroxisome proliferator-activated receptor-alpha (PPAR\u03b1) and AMP-activated protein kinase (AMPK) compared with the control. However, FA reversed the effect of AlCl\n                      <jats:sub>3<\/jats:sub>\n                      by significantly increasing hexokinase and pyruvate dehydrogenase activities, increasing the expression of GLUT4, CPT1\u03b2, PPAR\u03b1 and\u00a0AMPK.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0031_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      FA mitigate against cardiac metabolic disruption caused by acute exposure to AlCl\n                      <jats:sub>3<\/jats:sub>\n                      through PPAR\u03b1 and AMPK modulation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2026-0031","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:22:18Z","timestamp":1782901338000},"page":"425-435","source":"Crossref","is-referenced-by-count":0,"title":["Ferulic acid and not ascorbic acid reversed cardiac energy metabolism disruption in acute aluminum chloride exposed mice via PPAR\u03b1\/AMPK pathway"],"prefix":"10.1515","volume":"37","author":[{"given":"Olufemi I.","family":"Oluranti","sequence":"first","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence D.","family":"Adedayo","sequence":"additional","affiliation":[{"name":"Department of Human Physiology , College of Health Sciences, Federal University Wukari , Wukari , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther O.","family":"Ojo-Ayangoke","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolawole O.","family":"Adio","sequence":"additional","affiliation":[{"name":"Department of Human Physiology , Achievers University , Owo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olamide F.","family":"Aluko","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Orefuwa","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"},{"name":"Institute of Biomedical Research, Cardiovascular Sciences, University of Birmingham , Birmingham , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeoluwa D.","family":"Oladejo","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praise O.","family":"Toye","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omobolanle E.","family":"Ayantoyinbo","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babatunde A.","family":"Alabi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Bowen University , Iwo , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"2026092511295191612_j_jbcpp-2026-0031_ref_001","doi-asserted-by":"crossref","unstructured":"Lopaschuk, GD, Ussher, JR, Folmes, CD, Jaswal, JS, Stanley, WC. 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