{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:17:48Z","timestamp":1787912268800,"version":"build-2784847793"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2026-0035_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Painful diabetic neuropathy is a long-term complication of diabetes mellitus. However, the limitations of topical drug therapies have led to the development of plant-based treatments, such as red ginger. This study aimed to investigate the effectiveness of a red ginger extract emulgel (RGEE) for\u00a0PDN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0035_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mice were divided into seven groups: normal, PDN, positive control using capsaicin cream, and four treatment RGEE at 1\u202f%, 2%, 3%, and 4\u202f%. Mice were induced diabetic using streptozotocin 120\u202fmg\/kg BW. On the 14th day, topical treatments were administered for 28\u00a0days, with weekly monitoring of hyperalgesia. Mice were sacrificed on the 42nd day, and the plantars were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0035_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 3\u202f% RGEE had the most effective activity in reducing hyperalgesia, as well as the number of neutrophils and lymphocytes. In addition, the 3\u202f% RGEE reduced the expression of TRPV1 in the plantar of PDN mice and proved to be safe through acute dermal toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0035_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Red ginger extract emulgel 3\u202f% effectively reduced hyperalgesia, inflammation, and TRPV1 expression and was proven to be\u00a0safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2026-0035","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:56:01Z","timestamp":1787910961000},"source":"Crossref","is-referenced-by-count":0,"title":["Emulgel preparation from ethanol extract of red ginger rich in 6-shogaol as therapy for diabetic neuropathy pain: targeting TRPV-1 down-style"],"prefix":"10.1515","author":[{"given":"Fifteen Aprila","family":"Fajrin","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology and Animal Experimental, Faculty of Pharmacy, University of Jember , Jember , East Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Holidah","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Animal Experimental, Faculty of Pharmacy, University of Jember , Jember , East Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fransiska Maria","family":"Christianty","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Animal Experimental, Faculty of Pharmacy, University of Jember , Jember , East Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ika Puspita","family":"Dewi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Animal Experimental, Faculty of Pharmacy, University of Jember , Jember , East Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arief","family":"Nurrochmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy , Faculty of Pharmacy, Universitas Gadjah Mada , Yogyakarta , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heni","family":"Nurhidayah","sequence":"additional","affiliation":[{"name":"Preclinical Pharmacology Research Group, Faculty of Pharmacy, University of Jember , Jember , East Java , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026082809555922873_j_jbcpp-2026-0035_ref_001","doi-asserted-by":"crossref","unstructured":"Banday, MZ, Sameer, AS, Nissar, S. 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