{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:07:48Z","timestamp":1784635668382,"version":"3.55.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2026-0042_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Lead (Pb) exposure is a major environmental risk factor for male reproductive dysfunction, primarily mediated through oxidative stress and endocrine disruption. This study evaluated the effects of lead acetate on testicular antioxidant status and serum testosterone levels and investigated the ameliorative role of ascorbic acid (AA) in adult male Wistar\u00a0rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0042_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-five male Wistar rats were randomly assigned to seven groups (n=5): control, low- and high-dose lead (100 and 200\u202fmg\/kg), lead plus AA cotreatment, and withdrawal groups. Testicular antioxidant enzymes (SOD, CAT, GPx), reduced glutathione (GSH), and malondialdehyde (MDA) were assessed spectrophotometrically. Serum testosterone was measured using enzyme immunoassay. Data were analyzed using one-way ANOVA (p&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0042_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lead exposure significantly increased MDA levels and reduced antioxidant enzyme activities and testosterone concentrations in a dose-dependent manner (p&lt;0.05). Ascorbic acid coadministration significantly restored antioxidant status, elevated GSH levels, reduced lipid peroxidation, and improved testosterone levels compared with lead-only and withdrawal groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0042_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lead acetate induces oxidative and endocrine disturbances in testicular tissue. Ascorbic acid effectively mitigates lead-induced reproductive toxicity by preserving antioxidant defenses and maintaining testosterone homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2026-0042","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:59:31Z","timestamp":1779706771000},"page":"345-354","source":"Crossref","is-referenced-by-count":0,"title":["Ascorbic acid attenuates lead-induced oxidative stress and testosterone suppression in male Wistar rats"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8001-4258","authenticated-orcid":false,"given":"Ifeanyi Gideon","family":"Aja","sequence":"first","affiliation":[{"name":"Human Anatomy , Eko University of Medicine and Health Sciences , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Adesanya","family":"Adelaja","sequence":"additional","affiliation":[{"name":"Pediatrics , Ehanire Mother and Child Hospital , Benin City , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olawale Olusoga","family":"Olubi","sequence":"additional","affiliation":[{"name":"Department of Anatomy , College of Medicine, Lagos State University , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusegun David","family":"Avungbeto","sequence":"additional","affiliation":[{"name":"Physiology , Eko University of Medicine and Health Sciences , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026072111574566374_j_jbcpp-2026-0042_ref_001","doi-asserted-by":"crossref","unstructured":"Flora, G, Gupta, D, Tiwari, A. 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