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This review aims to integrate the biochemical and molecular evidence for the association between microplastic exposure and the development of impaired glucose metabolism via endocrine, inflammatory, and metabolic signaling pathways. These microplastics and additives, such as bisphenols, phthalates, and POPs, interact with nuclear hormone receptors, including the estrogen receptor, peroxisome proliferator-activated receptor, and aryl hydrocarbon receptor, resulting in aberrant transcriptional control of genes involved in the regulation of metabolism. Microplastics exposure may cause oxidative stress-mediated activation of stress kinases, inhibition of insulin receptor substrate-1, suppression of PI3K-Akt signaling, GLUT4 translocation, and mitochondrial dysfunction, which together result in systemic insulin resistance. In addition, \u03b2-cell damage, systemic inflammation, and changes in the gut microbiome interfere with the regulation of glucose metabolism in the liver, muscle, and adipose tissues.<\/jats:p>","DOI":"10.1515\/jbcpp-2026-0068","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T04:57:13Z","timestamp":1781499433000},"page":"267-279","source":"Crossref","is-referenced-by-count":1,"title":["Environmental diabetogens: biochemical links between microplastic exposure, endocrine disruption, and glucose metabolic dysfunction"],"prefix":"10.1515","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1640-2732","authenticated-orcid":false,"given":"Robin","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Hamdard Institute of Medical Science and Research , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Hamdard Institute of Medical Science and Research , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhumika","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Hamdard Institute of Medical Science and Research , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"2026072111574568208_j_jbcpp-2026-0068_ref_001","doi-asserted-by":"crossref","unstructured":"Kolb, H, Martin, S. 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