{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:16Z","timestamp":1790337796641,"version":"4.1.0"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2026-0077_abs_001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, particularly in high-risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0077_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the potential reno-protective effects of Tadalafil, a selective phosphodiesterase-5 (PDE-5) inhibitor, alone and in combination with ascorbic acid, in a cisplatin-induced AKI rat\u00a0model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0077_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty male albino rats (250\u2013300\u202fg) were randomly divided into five groups: control (A), cisplatin-treated (B), ascorbic acid-treated (100\u202fmg\/kg) (C), Tadalafil-treated (5\u202fmg\/kg) (D), and combined ascorbic acid\u00a0+\u00a0Tadalafil (E). Treatments were administered for 10\u00a0days prior to a single intraperitoneal dose of cisplatin (10\u202fmg\/kg). After 72\u202fh, blood and kidney tissue samples were collected for biochemical and histopathological analyses. Serum urea and creatinine, as well as renal tissue levels of NGAL, SOD, and TNF-\u03b1, were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0077_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cisplatin significantly increased urea, creatinine, TNF-\u03b1, and NGAL levels, while reducing SOD compared to control. Pre-treatment with Tadalafil, alone or in combination with ascorbic acid, significantly ameliorated these alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0077_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tadalafil in combination with ascorbic acid shows enhanced protective effects, suggesting greater protective effect role. Further studies are required to confirm its clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2026-0077","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:55:41Z","timestamp":1778831741000},"page":"387-394","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation the reno-protective effect of tadalafil alone and in combination with ascorbic acid in AKI model in rats"],"prefix":"10.1515","volume":"37","author":[{"given":"Tabarek Mohamed","family":"Salih","sequence":"first","affiliation":[{"name":"Medicine College , Babylon University , Hillah , Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Bashara","sequence":"additional","affiliation":[{"name":"Medicine College , Babylon University , Hillah , Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_001","doi-asserted-by":"crossref","unstructured":"Georgiadis, G, Zisis, IE, Docea, AO, Tsarouhas, K, Fragkiadoulaki, I, Mavridis, C, et al.. Current concepts on the reno-protective effects of phosphodiesterase 5 inhibitors in acute kidney injury: systematic search and review. J\u00a0Clin Med 2020;9. https:\/\/doi.org\/10.3390\/jcm9051284.","DOI":"10.3390\/jcm9051284"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_002","doi-asserted-by":"crossref","unstructured":"Gameiro, J, Fonseca, JA, Outerelo, C, Lopes, JA. Acute kidney injury: from diagnosis to prevention and treatment strategies. J Clin Med 2020;9:1704. https:\/\/doi.org\/10.3390\/jcm9061704.","DOI":"10.3390\/jcm9061704"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_003","doi-asserted-by":"crossref","unstructured":"Griffin, B, Faubel, S, CL, E. Biomarkers of drug-induced kidney toxicity benjamin. Ther Drug Monit 2020;41:213\u201326.","DOI":"10.1097\/FTD.0000000000000589"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_004","unstructured":"Adeneye, AA, Benebo, AS. Chemopreventive effect of tadalafil in cisplatin-induced nephrotoxicity in rats. Niger J Physiol Sci 2016;31:1\u201310."},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_005","doi-asserted-by":"crossref","unstructured":"Ko, SH, Jun, JH, Oh, JE, Shin, E, Kwak, YL, Shim, JK. Effect of high-dose vitamin C on renal ischemia-reperfusion injury. Biomed Pharmacother [Internet] 2024;173:116407. Available from: https:\/\/doi.org\/10.1016\/j.biopha.2024.116407.","DOI":"10.1016\/j.biopha.2024.116407"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_006","doi-asserted-by":"crossref","unstructured":"Hee, S, Hae, J, Eun, J, Shin, E, lan, KY. Biomedicine & pharmacotherapy effect of high-dose vitamin C on renal ischemia-reperfusion injury. Biomed Pharmacother [Internet] 2024;173:116407. Available from: https:\/\/doi.org\/10.1016\/j.biopha.2024.116407.","DOI":"10.1016\/j.biopha.2024.116407"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_007","doi-asserted-by":"crossref","unstructured":"Okafor, IA. Oxidative stress profile following the co-administration of cisplatin and resveratrol in female rats: a preliminary study. Physiol Pharmacol 2021;25:134\u201345. https:\/\/doi.org\/10.32598\/ppj.25.2.90.","DOI":"10.32598\/ppj.25.2.90"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_008","doi-asserted-by":"crossref","unstructured":"Sotoudeh, N, Namavar, MR. Optimisation of ketamine-xylazine anaesthetic dose and its association with changes in the dendritic spine of CA1 hippocampus in the young and old Male and female wistar rats. Vet Med Sci 2022;8:2545\u201352. https:\/\/doi.org\/10.1002\/vms3.936.","DOI":"10.1002\/vms3.936"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_009","doi-asserted-by":"crossref","unstructured":"Mechanisms, P, Interventions, P, Mcsweeney, KR, Gadanec, LK, Qaradakhi, T, Ali, BA, Zulli, A, Apostolopoulos, V. Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations. Cancers 2021;13:1572. https:\/\/doi.org\/10.3390\/cancers13071572.","DOI":"10.3390\/cancers13071572"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_010","doi-asserted-by":"crossref","unstructured":"Kwiatkowska, E, Doma\u0144ski, L, Dziedziejko, V, Kajdy, A, Stefa\u0144ska, K, Kwiatkowski, S. The mechanism of drug nephrotoxicity and the methods for preventing kidney damage. Int J Mol Sci 2021;22. https:\/\/doi.org\/10.3390\/ijms22116109.","DOI":"10.3390\/ijms22116109"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_011","doi-asserted-by":"crossref","unstructured":"Griffin, BR, Faubel, S, Edelstein, CL. Biomarkers of drug-induced kidney toxicity. Ther Drug Monit 2019;41:213\u201326. https:\/\/doi.org\/10.1097\/ftd.0000000000000589.","DOI":"10.1097\/FTD.0000000000000589"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_012","doi-asserted-by":"crossref","unstructured":"Adeneye, AA, Babatope, FE, Adesiji-Adelekan, AE, Olorundare, OE, Okoye, II. Tadalafil pretreatment attenuates doxorubicin-induced hepatorenal toxicity by modulating oxidative stress and inflammation in wistar rats. Toxicol Rep 2024;13. https:\/\/doi.org\/10.1016\/j.toxrep.2024.101737.","DOI":"10.1016\/j.toxrep.2024.101737"},{"key":"2026092511295348173_j_jbcpp-2026-0077_ref_013","doi-asserted-by":"crossref","unstructured":"Lee, EH, Yoo, ES, Yoon, BH, Jeon, M, Kwon, TG, Kim, BS, et al.. The renoprotective effects of tadalafil on ischemia\u2013reperfusion injury during partial nephrectomy in an animal model. 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