{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:20Z","timestamp":1790337800902,"version":"4.1.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2026-0090_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether ginsenoside Rg1 attenuates right ventricular remodeling in hypoxic pulmonary hypertension and whether this effect is associated with suppression of HIF-1\u03b1\u2013related glycolytic signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0090_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male C57BL\/6 mice were exposed to normobaric hypoxia (10\u202f% O\n                      <jats:sub>2<\/jats:sub>\n                      ) for 4\u00a0weeks and assigned to control, model, sildenafil, Rg1, or HIF-1\u03b1 knockdown groups (n=10 per group). Pulmonary function, hemodynamic parameters, right ventricular hypertrophy, histopathology, oxidative stress, apoptosis, immunofluorescence, and protein expression in right ventricular tissue were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0090_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypoxia reduced forced expiratory volume in 0.3\u202fs\/forced vital capacity and increased mean pulmonary arterial pressure, right ventricular systolic pressure, and right ventricular hypertrophy index. It also induced myocardial disorganization, collagen deposition, oxidative stress, apoptosis, and increased expression of HIF-1\u03b1, glucose transporter 1, hexokinase 2, 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase 3, lactate dehydrogenase A, transforming growth factor beta 1, Smad2, and collagen I. Rg1 significantly attenuated these abnormalities, with a pattern broadly comparable to HIF-1\u03b1 knockdown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2026-0090_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rg1 attenuated hypoxia-induced right ventricular remodeling and fibrosis and was associated with reduced oxidative injury, apoptosis, and HIF-1\u03b1\u2013related glycolytic and profibrotic signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2026-0090","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:54:15Z","timestamp":1779915255000},"page":"437-446","source":"Crossref","is-referenced-by-count":0,"title":["Ginsenoside Rg1 attenuates right ventricular remodeling in hypoxic pulmonary hypertension and is associated with suppression of HIF-1\u03b1\u2013related glycolytic signaling"],"prefix":"10.1515","volume":"37","author":[{"given":"Peng","family":"He","sequence":"first","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fan","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"},{"name":"Department of Respiratory Medicine , Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9208-4912","authenticated-orcid":false,"given":"Guangbo","family":"Tan","sequence":"additional","affiliation":[{"name":"Graduate School, Hunan University of Chinese Medicine , Changsha , Hunan , China"},{"name":"Department of Respiratory Medicine , Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine , Changsha , Hunan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"2026092511294579492_j_jbcpp-2026-0090_ref_001","doi-asserted-by":"crossref","unstructured":"Poch, D, Mandel, J. 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