{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:03:11Z","timestamp":1790337791877,"version":"4.1.0"},"reference-count":131,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the cardioprotective effects of luteolin, a naturally occurring flavonoid, in mitigating critical pathological processes linked to cardiovascular diseases (CVDs), including oxidative stress, inflammation, mitochondrial dysfunction, and endothelial damage. Luteolin, found in celery, parsley, green peppers, and chamomile tea, exhibits significant cardioprotective properties through various mechanisms. It activates the Nrf2\/HO-1 antioxidant pathway, suppresses NF-\u03baB-mediated inflammation, regulates apoptosis, and preserves the functionality of endothelial nitric oxide synthase (eNOS). In\u00a0preclinical studies involving isoproterenol- and doxorubicin-induced cardiotoxicity, luteolin was shown to reduce oxidative stress, decrease apoptosis, and improve cardiac structure and function. Compared to other flavonoids like quercetin and resveratrol, luteolin demonstrates more potent endothelial-protective effects and a balanced modulation of antioxidant and apoptotic pathways. The diverse actions and natural origin of luteolin make it a promising candidate for CVD prevention and as an adjunctive therapy. Future research should focus on rigorously designed clinical trials to validate its efficacy in heart failure, ischemic injury, and drug-induced cardiotoxicity, thus enhancing its application in clinical practice.<\/jats:p>","DOI":"10.1515\/jbcpp-2026-0104","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:56:59Z","timestamp":1786694219000},"page":"361-379","source":"Crossref","is-referenced-by-count":0,"title":["A recent update on luteolin: mechanisms and therapeutic implications in cardiac disease"],"prefix":"10.1515","volume":"37","author":[{"given":"Aysha","family":"Javed","sequence":"first","affiliation":[{"name":"College of Pharmacy, Integral University , Phase-III, Kursi Road , Barabanki , U.P. , India-225302"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Integral University , Dasauli, Kursi Road , Lucknow , U.P. , 226026 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farogh","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Integral University , Dasauli, Kursi Road , Lucknow , U.P. , 226026 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimen","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Integral University , Dasauli, Kursi Road , Lucknow , U.P. , 226026 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Integral University , Dasauli, Kursi Road , Lucknow , U.P. , 226026 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shariq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Integral University , Dasauli, Kursi Road , Lucknow , U.P. , 226026 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Baseer","family":"Khan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integral University , Phase-III, Kursi Road , Barabanki , U.P. , India-225302"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_001","doi-asserted-by":"crossref","unstructured":"Noor, FM, Islam, MM. Prevalence and associated risk factors of mortality among COVID-19 patients: a meta-analysis. J\u00a0Community Health 2020;45:1270\u201382. https:\/\/doi.org\/10.1007\/s10900-020-00920-x.","DOI":"10.1007\/s10900-020-00920-x"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_002","doi-asserted-by":"crossref","unstructured":"Periasamy, P, Ujwala, R, Srikar, K, Durga Sai, Y, Preetha, K, Sumathi, D, et al.. ERAM-EE: efficient resource allocation and management strategies with energy efficiency under fog\u2013internet of things environments. Connect Sci 2024;36:2350755. https:\/\/doi.org\/10.1080\/09540091.2024.2350755.","DOI":"10.1080\/09540091.2024.2350755"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_003","doi-asserted-by":"crossref","unstructured":"Alam, MS, Alam, MN, Murshed, M, Mahmood, H, Alam, R. Pathways to securing environmentally sustainable economic growth through efficient use of energy: a bootstrapped ARDL analysis. Environ Sci Pollut Res 2022;29:50025\u201339. https:\/\/doi.org\/10.1007\/s11356-022-19410-9.","DOI":"10.1007\/s11356-022-19410-9"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_004","doi-asserted-by":"crossref","unstructured":"Tiwari, S, Atluri, V, Kaushik, A, Yndart, A, Nair, M. Alzheimer\u2019s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomed 2019;14:5541\u201354. https:\/\/doi.org\/10.2147\/IJN.S200490.","DOI":"10.2147\/IJN.S200490"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_005","doi-asserted-by":"crossref","unstructured":"Harborne, JB, Williams, CA. Advances in flavonoid research since 1992. Phytochemistry 2000;55:481\u2013504. https:\/\/doi.org\/10.1016\/S0031-9422(00)00235-1.","DOI":"10.1016\/S0031-9422(00)00235-1"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_006","doi-asserted-by":"crossref","unstructured":"Javed, A, Mahmood, T, Ahsan, F, Shamim, A, Khan, A, Srivastava, S, et al.. An In-depth analysis of luteolin regarding its preclinical, clinical and nanoformulations perspectives. Nat Prod J 2025;15. https:\/\/doi.org\/10.2174\/0122103155316738240901181513.","DOI":"10.2174\/0122103155316738240901181513"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_007","doi-asserted-by":"crossref","unstructured":"Perez-Vizcaino, F, Fraga, CG. Research trends in flavonoids and health. Arch Biochem Biophys 2018;646:107\u201312. https:\/\/doi.org\/10.1016\/j.abb.2018.03.022.","DOI":"10.1016\/j.abb.2018.03.022"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_008","doi-asserted-by":"crossref","unstructured":"Lopez-Lazaro, M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 2009;9:31\u201359. https:\/\/doi.org\/10.2174\/138955709787001712.","DOI":"10.2174\/138955709787001712"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_009","doi-asserted-by":"crossref","unstructured":"Chaturvedi, S, Tiwari, V, Gangadhar, NM, Rashid, M, Sultana, N, Singh, SK, et al.. Isoformononetin, a dietary isoflavone protects against streptozotocin induced rat model of neuroinflammation through inhibition of NLRP3\/ASC\/IL-1 axis activation. Life Sci 2021;286:119989. https:\/\/doi.org\/10.1016\/j.lfs.2021.119989.","DOI":"10.1016\/j.lfs.2021.119989"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_010","doi-asserted-by":"crossref","unstructured":"Beecher, GR. Overview of dietary flavonoids: nomenclature, occurrence and intake. J\u00a0Nutr 2003;133:3248S\u20133254S. https:\/\/doi.org\/10.1093\/jn\/133.10.3248S.","DOI":"10.1093\/jn\/133.10.3248S"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_011","doi-asserted-by":"crossref","unstructured":"Cottam, R. Is public health coercive health? Lancet 2005;366:1592\u20134. https:\/\/doi.org\/10.1016\/S0140-6736(05)67644-1.","DOI":"10.1016\/S0140-6736(05)67644-1"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_012","doi-asserted-by":"crossref","unstructured":"Manach, C, Williamson, G, Morand, C, Scalbert, A, R\u00e9m\u00e9sy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005;81:230S\u2013242S. https:\/\/doi.org\/10.1093\/ajcn\/81.1.230S.","DOI":"10.1093\/ajcn\/81.1.230S"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_013","doi-asserted-by":"crossref","unstructured":"Cassidy, A. Factors affecting the bioavailability of soy isoflavones in humans. J\u00a0AOAC Int 2006;89:1182\u20138. https:\/\/doi.org\/10.1093\/jaoac\/89.4.1182.","DOI":"10.1093\/jaoac\/89.4.1182"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_014","doi-asserted-by":"crossref","unstructured":"Wahajuddin, null, Taneja, I, Arora, S, Raju, KSR, Siddiqui, N. Disposition of pharmacologically active dietary isoflavones in biological systems. Curr Drug Metabol 2013;14:369\u201380. https:\/\/doi.org\/10.2174\/1389200211314040002.","DOI":"10.2174\/1389200211314040002"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_015","doi-asserted-by":"crossref","unstructured":"Taneja, I, Raju, KSR, Wahajuddin, M. Dietary isoflavones as modulators of drug metabolizing enzymes and transporters: effect on prescription medicines. Crit Rev Food Sci Nutr 2016;56:S95\u2013109. https:\/\/doi.org\/10.1080\/10408398.2015.1045968.","DOI":"10.1080\/10408398.2015.1045968"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_016","doi-asserted-by":"crossref","unstructured":"Messina, M. Soy and health update: evaluation of the clinical and epidemiologic literature. Nutrients 2016;8:754. https:\/\/doi.org\/10.3390\/nu8120754.","DOI":"10.3390\/nu8120754"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_017","doi-asserted-by":"crossref","unstructured":"Shang, J, Yang, J, Deng, Q, Zhou, M. Nano-scale drug delivery systems for luteolin: advancements and applications. J\u00a0Mater Chem B 2023;11:11198\u2013216. https:\/\/doi.org\/10.1039\/D3TB01753B.","DOI":"10.1039\/D3TB01753B"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_018","doi-asserted-by":"crossref","unstructured":"Sun, G, Sun, X, Wang, M, Ye, J, Si, J, Xu, H, et al.. Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression. Toxicol Appl Pharmacol 2012;265:229\u201340. https:\/\/doi.org\/10.1016\/j.taap.2012.10.002.","DOI":"10.1016\/j.taap.2012.10.002"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_019","doi-asserted-by":"crossref","unstructured":"Ntalouka, F, Tsirivakou, A. Luteolin: a promising natural agent in management of pain in chronic conditions. Front. Pain Res 2023;4:1114428 https:\/\/doi.org\/10.3389\/fpain.2023.1114428.","DOI":"10.3389\/fpain.2023.1114428"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_020","doi-asserted-by":"crossref","unstructured":"Hayasaka, N, Shimizu, N, Komoda, T, Mohri, S, Tsushida, T, Eitsuka, T, et al.. Absorption and metabolism of luteolin in rats and humans in relation to in\u00a0vitro anti-inflammatory effects. J\u00a0Agric Food Chem 2018;66:11320\u20139. https:\/\/doi.org\/10.1021\/acs.jafc.8b03273.","DOI":"10.1021\/acs.jafc.8b03273"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_021","doi-asserted-by":"crossref","unstructured":"Ohno-Matsui, K, Kawasaki, R, Jonas, JB, Cheung, CMG, Saw, SM, Verhoeven, VJ, et al.. International photographic classification and grading system for myopic maculopathy. Am J Ophthalmol 2015;159:877\u201383.e7. https:\/\/doi.org\/10.1016\/j.ajo.2015.01.022.","DOI":"10.1016\/j.ajo.2015.01.022"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_022","doi-asserted-by":"crossref","unstructured":"Kidder, GW, Montgomery, CW. Oxygenation of frog gastric mucosa in\u00a0vitro. Am J Physiol 1975;229:1510\u201313. https:\/\/doi.org\/10.1152\/ajplegacy.1975.229.6.1510.","DOI":"10.1152\/ajplegacy.1975.229.6.1510"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_023","doi-asserted-by":"crossref","unstructured":"Kure, A, Nakagawa, K, Kondo, M, Kato, S, Kimura, F, Watanabe, A, et al.. Metabolic fate of luteolin in rats: its relationship to anti-inflammatory effect. J\u00a0Agric Food Chem 2016;64:4246. https:\/\/doi.org\/10.1021\/acs.jafc.6b00964.","DOI":"10.1021\/acs.jafc.6b00964"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_024","doi-asserted-by":"crossref","unstructured":"Wang, Y, Bryant, SH, Cheng, T, Wang, J, Gindulyte, A, Shoemaker, BA, et al.. PubChem BioAssay: 2017 update. Nucleic Acids Res 2017;45:D955\u201363. https:\/\/doi.org\/10.1093\/nar\/gkw1118.","DOI":"10.1093\/nar\/gkw1118"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_025","doi-asserted-by":"crossref","unstructured":"Paysan-Lafosse, T, Blum, M, Chuguransky, S, Grego, T, Pinto, BL, Salazar, G, et al.. InterPro in 2022. Nucleic Acids Res 2023;51:D418\u201327. https:\/\/doi.org\/10.1093\/nar\/gkac993.","DOI":"10.1093\/nar\/gkac993"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_026","doi-asserted-by":"crossref","unstructured":"Hsieh, Y-S, Chen, Y-F, Cheng, Y-Y, Liu, W-Y, Wu, Y-T. Self-emulsifying phospholipid preconcentrates for the enhanced photoprotection of luteolin. Pharmaceutics 2022;14:1896. https:\/\/doi.org\/10.3390\/pharmaceutics14091896.","DOI":"10.3390\/pharmaceutics14091896"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_027","doi-asserted-by":"crossref","unstructured":"Zhou, D, Bai, Z, Guo, T, Li, J, Li, Y, Hou, Y, et al.. Dietary flavonoids and human top-ranked diseases: the perspective of in\u00a0vivo bioactivity and bioavailability. Trends Food Sci Technol 2022;120:374\u201386. https:\/\/doi.org\/10.1016\/j.tifs.2022.01.019.","DOI":"10.1016\/j.tifs.2022.01.019"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_028","doi-asserted-by":"crossref","unstructured":"Wu, M, Han, W, Song, S, Du, Y, Liu, C, Chen, N, et al.. NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice. Mol Cell Endocrinol 2018;478:115\u201325. https:\/\/doi.org\/10.1016\/j.mce.2018.08.002.","DOI":"10.1016\/j.mce.2018.08.002"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_029","doi-asserted-by":"crossref","unstructured":"Kar, S, Das, R, Baug, T. Investigation of [KSF2015] 1381-19L, a WC9-type star in the high-extinction galactic Region. Astrophys J 2024;968:60. https:\/\/doi.org\/10.3847\/1538-4357\/ad4131.","DOI":"10.3847\/1538-4357\/ad4131"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_030","doi-asserted-by":"crossref","unstructured":"Taheri, Y, Sharifi-Rad, J, Antika, G, Y\u0131lmaz, YB, Tumer, TB, Abuhamdah, S, et al.. Paving luteolin therapeutic potentialities and agro-food-pharma applications: emphasis on in\u00a0vivo pharmacological effects and bioavailability traits. Oxid Med Cell Longev 2021;2021:1987588. https:\/\/doi.org\/10.1155\/2021\/1987588.","DOI":"10.1155\/2021\/1987588"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_031","doi-asserted-by":"crossref","unstructured":"Junaid, SB, Imam, AA, Balogun, AO, De Silva, LC, Surakat, YA, Kumar, G, et al.. Recent advancements in emerging technologies for healthcare management systems: a survey. Healthcare 2022;10:1940. https:\/\/doi.org\/10.3390\/healthcare10101940.","DOI":"10.3390\/healthcare10101940"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_032","doi-asserted-by":"crossref","unstructured":"Miao, Q, Schwarz, S, Schwarz, G. Responding to COVID-19: community volunteerism and coproduction in China. World Dev 2021;137:105128. https:\/\/doi.org\/10.1016\/j.worlddev.2020.105128.","DOI":"10.1016\/j.worlddev.2020.105128"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_033","doi-asserted-by":"crossref","unstructured":"Ren, X, Li, J, He, F, Lucey, B. Impact of climate policy uncertainty on traditional energy and green markets: evidence from time-varying granger tests. Renew Sustain Energy Rev 2023;173:113058. https:\/\/doi.org\/10.1016\/j.rser.2022.113058.","DOI":"10.1016\/j.rser.2022.113058"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_034","doi-asserted-by":"crossref","unstructured":"Singh, BP, Bangar, SP, Alblooshi, M, Ajayi, FF, Mudgil, P, Maqsood, S. Plant-derived proteins as a sustainable source of bioactive peptides: recent research updates on emerging production methods, bioactivities, and potential application. Crit Rev Food Sci Nutr 2023;63:9539\u201360. https:\/\/doi.org\/10.1080\/10408398.2022.2067120.","DOI":"10.1080\/10408398.2022.2067120"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_035","doi-asserted-by":"crossref","unstructured":"Hayasaka, D, Kobashi, K, Hashimoto, K. Community responses of aquatic insects in paddy mesocosms to repeated exposures of the neonicotinoids imidacloprid and dinotefuran. Ecotoxicol Environ Saf 2019;175:272\u201381. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.03.051.","DOI":"10.1016\/j.ecoenv.2019.03.051"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_036","doi-asserted-by":"crossref","unstructured":"Folke, C, Polasky, S, Rockstr\u00f6m, J, Galaz, V, Westley, F, Lamont, M, et al.. Our future in the anthropocene biosphere. Ambio 2021;50:834\u201369. https:\/\/doi.org\/10.1007\/s13280-021-01544-8.","DOI":"10.1007\/s13280-021-01544-8"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_037","doi-asserted-by":"crossref","unstructured":"Kahn, T, Bosch, J, Levitt, MF, Goldstein, MH. Effect of sodium nitrate loading on electrolyte transport by the renal tubule. Am J Physiol 1975;229:746\u201353. https:\/\/doi.org\/10.1152\/ajplegacy.1975.229.3.746.","DOI":"10.1152\/ajplegacy.1975.229.3.746"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_038","doi-asserted-by":"crossref","unstructured":"Wang, J, Shi, E, Hu, H, Ma, C, Liu, Y, Wang, X, et al.. Large language models for robotics: opportunities, challenges, and perspectives. J\u00a0Autom Intell 2025;4:52\u201364. https:\/\/doi.org\/10.1016\/j.jai.2024.12.003.","DOI":"10.1016\/j.jai.2024.12.003"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_039","doi-asserted-by":"crossref","unstructured":"Gillespie, M, Jassal, B, Stephan, R, Milacic, M, Rothfels, K, Senff-Ribeiro, A, et al.. The reactome pathway knowledgebase 2022. Nucleic Acids Res 2022;50:D687\u201392. https:\/\/doi.org\/10.1093\/nar\/gkab1028.","DOI":"10.1093\/nar\/gkab1028"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_040","doi-asserted-by":"crossref","unstructured":"Fernando, PDSM, Ko, DO, Piao, MJ, Kang, KA, Herath, HMUL, Hyun, JW. Protective effect of luteolin against oxidative stress-mediated cell injury via enhancing antioxidant systems. Mol Med Rep 2024;30:121. https:\/\/doi.org\/10.3892\/mmr.2024.13244.","DOI":"10.3892\/mmr.2024.13244"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_041","doi-asserted-by":"crossref","unstructured":"Kahksha, Alam, O, Al-Keridis, LA, Khan, J, Naaz, S, Alam, A, et al.. Evaluation of antidiabetic effect of luteolin in STZ induced diabetic rats: molecular docking, molecular dynamics, in vitro and in vivo studies. J\u00a0Funct Biomater 2023;14:126. https:\/\/doi.org\/10.3390\/jfb14030126.","DOI":"10.3390\/jfb14030126"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_042","doi-asserted-by":"crossref","unstructured":"Han, D, Chung, M, Park, Y. Association of dietary total antioxidant capacity with cancer recurrence and mortality among breast cancer survivors: a prospective cohort study. Nutr Cancer 2022;74:3253\u201362. https:\/\/doi.org\/10.1080\/01635581.2022.2074061.","DOI":"10.1080\/01635581.2022.2074061"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_043","doi-asserted-by":"crossref","unstructured":"Pan, Q, Liu, Y, Ma, W, Kan, R, Zhu, H, Li, D. Cardioprotective effects and possible mechanisms of luteolin for myocardial ischemia-reperfusion injury: a systematic review and meta-analysis of preclinical evidence. Front Cardiovasc Med 2022;9:685998. https:\/\/doi.org\/10.3389\/fcvm.2022.685998.","DOI":"10.3389\/fcvm.2022.685998"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_044","doi-asserted-by":"crossref","unstructured":"Luo, Y, Shang, P, Li, D. Luteolin: a flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Front Pharmacol 2017;8:692. https:\/\/doi.org\/10.3389\/fphar.2017.00692.","DOI":"10.3389\/fphar.2017.00692"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_045","doi-asserted-by":"crossref","unstructured":"Vongthip, W, Nilkhet, S, Boonruang, K, Sukprasansap, M, Tencomnao, T, Baek, SJ. Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death. Sci Rep 2024;14:7707. https:\/\/doi.org\/10.1038\/s41598-024-57824-2.","DOI":"10.1038\/s41598-024-57824-2"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_046","doi-asserted-by":"crossref","unstructured":"Calderon-Montano, JM, Burgos-Moron, E, Perez-Guerrero, C, Lopez-Lazaro, M. A review on the dietary flavonoid kaempferol. Mini Rev Med Chem 2011;11:298\u2013344. https:\/\/doi.org\/10.2174\/138955711795305335.","DOI":"10.2174\/138955711795305335"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_047","doi-asserted-by":"crossref","unstructured":"Ahsan, F, Mahmood, T, Usmani, S, Bagga, P, Shamim, A, Tiwari, R, et al.. A conglomeration of preclinical models related to myocardial infarction. Braz J Pharm Sci 2020;56. https:\/\/doi.org\/10.1590\/s2175-97902019000418365.","DOI":"10.1590\/s2175-97902019000418365"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_048","doi-asserted-by":"crossref","unstructured":"Wasim, R, Mahmood, T, Siddiqui, MH, Ahsan, F, Shamim, A, Singh, A, et al.. Aftermath of AGE-RAGE cascade in the pathophysiology of cardiovascular ailments. Life Sci 2022;307:120860. https:\/\/doi.org\/10.1016\/j.lfs.2022.120860.","DOI":"10.1016\/j.lfs.2022.120860"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_049","doi-asserted-by":"crossref","unstructured":"Pan, M-H, Lai, C-S, Ho, C-T. Anti-inflammatory activity of natural dietary flavonoids. Food Funct 2010;1:15. https:\/\/doi.org\/10.1039\/c0fo00103a.","DOI":"10.1039\/c0fo00103a"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_050","doi-asserted-by":"crossref","unstructured":"Perwez Hussain, S, Harris, CC. Inflammation and cancer: an ancient link with novel potentials. Int J Cancer 2007;121:2373\u201380. https:\/\/doi.org\/10.1002\/ijc.23173.","DOI":"10.1002\/ijc.23173"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_051","doi-asserted-by":"crossref","unstructured":"Kansara, A, Mubeen, F, Shakil, J. SGLT2 inhibitors in patients with chronic kidney disease and heart disease: a literature review. Methodist DeBakey Cardiovasc J 2022;18:62\u201372. https:\/\/doi.org\/10.14797\/mdcvj.1120.","DOI":"10.14797\/mdcvj.1120"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_052","doi-asserted-by":"crossref","unstructured":"Zhao, S, Lin, Q, Ran, J, Musa, SS, Yang, G, Wang, W, et al.. Preliminary\u00a0estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak. Int J Infect Dis 2020;92:214\u201317. https:\/\/doi.org\/10.1016\/j.ijid.2020.01.050.","DOI":"10.1016\/j.ijid.2020.01.050"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_053","doi-asserted-by":"crossref","unstructured":"Djeujo, FM, Ragazzi, E, Urettini, M, Sauro, B, Cichero, E, Tonelli, M, et al.. Magnolol and luteolin inhibition of \u03b1-glucosidase activity: kinetics and type of interaction detected by in\u00a0vitro and in\u00a0silico studies. Pharmaceuticals 2022;15:205. https:\/\/doi.org\/10.3390\/ph15020205.","DOI":"10.3390\/ph15020205"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_054","doi-asserted-by":"crossref","unstructured":"Nayar, U, Cohen, O, Kapstad, C, Cuoco, MS, Waks, AG, Wander, SA, et al.. Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor\u2013directed therapies. Nat Genet 2019;51:207\u201316. https:\/\/doi.org\/10.1038\/s41588-018-0287-5.","DOI":"10.1038\/s41588-018-0287-5"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_055","doi-asserted-by":"crossref","unstructured":"Zang, Y, Igarashi, K, Li, Y. Anti-diabetic effects of luteolin and luteolin-7- O\u00a0-glucoside on KK- A y mice. Biosci Biotechnol Biochem 2016;80:1580\u20136. https:\/\/doi.org\/10.1080\/09168451.2015.1116928.","DOI":"10.1080\/09168451.2015.1116928"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_056","doi-asserted-by":"crossref","unstructured":"Chang, X, Yue, R. Therapeutic potential of luteolin for diabetes mellitus and its complications. Chin J Integr Med 2025;31:566\u201376. https:\/\/doi.org\/10.1007\/s11655-024-3917-z.","DOI":"10.1007\/s11655-024-3917-z"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_057","doi-asserted-by":"crossref","unstructured":"Lin, Y, Shi, R, Wang, X, Shen, H-M. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 2008;8:634\u201346. https:\/\/doi.org\/10.2174\/156800908786241050.","DOI":"10.2174\/156800908786241050"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_058","doi-asserted-by":"crossref","unstructured":"Babu, PVA, Liu, D, Gilbert, ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J\u00a0Nutr Biochem 2013;24:1777\u201389. https:\/\/doi.org\/10.1016\/j.jnutbio.2013.06.003.","DOI":"10.1016\/j.jnutbio.2013.06.003"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_059","doi-asserted-by":"crossref","unstructured":"Yang, J-T, Qian, LB, Zhang, FJ, Wang, J, Ai, H, Tang, LH, et al.. Cardioprotective effects of luteolin on ischemia\/reperfusion injury in diabetic rats are modulated by eNOS and the mitochondrial permeability transition pathway. J\u00a0Cardiovasc Pharmacol 2015;65:349\u201356. https:\/\/doi.org\/10.1097\/FJC.0000000000000202.","DOI":"10.1097\/FJC.0000000000000202"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_060","doi-asserted-by":"crossref","unstructured":"Zheng, J, An, Y, Du, Y, Song, Y, Zhao, Q, Lu, Y. Effects of short-chain fatty acids on blood glucose and lipid levels in mouse models of diabetes mellitus: a systematic review and network meta-analysis. Pharmacol Res 2024;199:107041. https:\/\/doi.org\/10.1016\/j.phrs.2023.107041.","DOI":"10.1016\/j.phrs.2023.107041"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_061","doi-asserted-by":"crossref","unstructured":"Le Marchand, L. Cancer preventive effects of flavonoids\u00a0\u2013\u00a0a review. Biomed Pharmacother 2002;56:296\u2013301. https:\/\/doi.org\/10.1016\/S0753-3322(02)00186-5.","DOI":"10.1016\/S0753-3322(02)00186-5"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_062","doi-asserted-by":"crossref","unstructured":"Chen, L, Huang, Z, Li, Q, Chen, C, Luo, Y, Kang, P. Activated intestinal microbiome-associated tryptophan metabolism upregulates aryl hydrocarbon receptor to promote osteoarthritis in a rat model. Int Immunopharmacol 2023;118:110020. https:\/\/doi.org\/10.1016\/j.intimp.2023.110020.","DOI":"10.1016\/j.intimp.2023.110020"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_063","unstructured":"Hayat, MA, editor. Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging. Amsterdam: Boston: Elsevier, Academic Press; 2016."},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_064","doi-asserted-by":"crossref","unstructured":"Lind, L, Araujo, JA, Barchowsky, A, Belcher, S, Berridge, BR, Chiamvimonvat, N, et al.. Key characteristics of cardiovascular toxicants. Environ Health Perspect 2021;129:095001. https:\/\/doi.org\/10.1289\/EHP9321.","DOI":"10.1289\/EHP9321"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_065","doi-asserted-by":"crossref","unstructured":"Arcopinto, M, Isgaard, J, Marra, AM, Formisano, P, Bossone, E, Vriz, O, et al.. IGF-1 predicts survival in chronic heart failure. Insights from the T.O.S.CA. (Trattamento Ormonale Nello Scompenso CArdiaco) registry. Int J Cardiol 2014;176:1006\u20138. https:\/\/doi.org\/10.1016\/j.ijcard.2014.07.003.","DOI":"10.1016\/j.ijcard.2014.07.003"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_066","doi-asserted-by":"crossref","unstructured":"D\u2019Assante, R, Arcopinto, M, Rengo, G, Salzano, A, Walser, M, Gambino, G, et al.. Myocardial expression of somatotropic axis, adrenergic signalling, and calcium handling genes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. ESC Heart Fail 2021;8:1681\u20136. https:\/\/doi.org\/10.1002\/ehf2.13067.","DOI":"10.1002\/ehf2.13067"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_067","doi-asserted-by":"crossref","unstructured":"Morelli, MB, Bongiovanni, C, Da Pra, S, Miano, C, Sacchi, F, Lauriola, M, et al.. Cardiotoxicity of anticancer drugs: molecular mechanisms and strategies for cardioprotection. Front Cardiovasc Med 2022;9:847012. https:\/\/doi.org\/10.3389\/fcvm.2022.847012.","DOI":"10.3389\/fcvm.2022.847012"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_068","doi-asserted-by":"crossref","unstructured":"Sawyer, DB. Anthracyclines and heart failure. N\u00a0Engl J Med 2013;368:1154\u20136. https:\/\/doi.org\/10.1056\/NEJMcibr1214975.","DOI":"10.1056\/NEJMcibr1214975"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_069","doi-asserted-by":"crossref","unstructured":"Suter, TM, Ewer, MS. Cancer drugs and the heart: importance and management. Eur Heart J 2013;34:1102\u201311. https:\/\/doi.org\/10.1093\/eurheartj\/ehs181.","DOI":"10.1093\/eurheartj\/ehs181"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_070","doi-asserted-by":"crossref","unstructured":"Braverman, AC, Antin, JH, Plappert, MT, Cook, EF, Lee, RT. Cyclophosphamide cardiotoxicity in bone marrow transplantation: a prospective evaluation of new dosing regimens. J\u00a0Clin Oncol 1991;9:1215\u201323. https:\/\/doi.org\/10.1200\/JCO.1991.9.7.1215.","DOI":"10.1200\/JCO.1991.9.7.1215"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_071","unstructured":"de La Coussaye, JE, Eledjam, JJ, Brugada, J, Sassine, A. Cardiotoxicity of local anesthetics. Cah Anesthesiol 1993;41:589\u201398."},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_072","doi-asserted-by":"crossref","unstructured":"Huang, M-Z, Li, J-Y. Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties. Acta Physiol Oxf Engl 2020;228:e13351. https:\/\/doi.org\/10.1111\/apha.13351.","DOI":"10.1111\/apha.13351"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_073","doi-asserted-by":"crossref","unstructured":"Chowdhury, S, Sinha, K, Banerjee, S, Sil, PC. Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses. Biofactors 2016;42:647\u201364. https:\/\/doi.org\/10.1002\/biof.1301.","DOI":"10.1002\/biof.1301"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_074","doi-asserted-by":"crossref","unstructured":"Stone, JR, Kanneganti, R, Abbasi, M, Akhtari, M. Monitoring for chemotherapy-related cardiotoxicity in the form of left ventricular systolic dysfunction: a review of Current recommendations. JCO Oncol Pract 2021;17:228\u201336. https:\/\/doi.org\/10.1200\/OP.20.00924.","DOI":"10.1200\/OP.20.00924"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_075","doi-asserted-by":"crossref","unstructured":"Tousif, S, Singh, AP, Umbarkar, P, Galindo, C, Wheeler, N, Toro Cora, A, et al.. Ponatinib drives cardiotoxicity by S100A8\/A9-NLRP3-IL-1\u03b2 mediated inflammation. Circ Res 2023;132:267\u201389. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.321504.","DOI":"10.1161\/CIRCRESAHA.122.321504"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_076","doi-asserted-by":"crossref","unstructured":"Hamo, CE, Bloom, MW. Getting to the heart of the matter: an overview of cardiac toxicity related to cancer therapy. Clin Med Insights Cardiol 2015;9s2:CMC.S19704. https:\/\/doi.org\/10.4137\/CMC.S19704.","DOI":"10.4137\/CMC.S19704"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_077","doi-asserted-by":"crossref","unstructured":"Belmonte, F, Das, S, Sysa-Shah, P, Sivakumaran, V, Stanley, B, Guo, X, et al.. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol 2015;309:H1271\u2013H12https:\/\/doi.org\/10.1152\/ajpheart.00517.2014.","DOI":"10.1152\/ajpheart.00517.2014"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_078","doi-asserted-by":"crossref","unstructured":"Keirns, J, Desai, A, Kowalski, D, Lademacher, C, Mujais, S, Parker, B, et al.. QT interval shortening with isavuconazole: in\u00a0vitro and in\u00a0vivo effects on cardiac repolarization. Clin Pharmacol Ther 2017;101:782\u201390. https:\/\/doi.org\/10.1002\/cpt.620.","DOI":"10.1002\/cpt.620"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_079","doi-asserted-by":"crossref","unstructured":"Hosseini, A, Rajabian, A, Sobhanifar, MA, Alavi, MS, Taghipour, Z, Hasanpour, M, et al.. Attenuation of isoprenaline-induced myocardial infarction by Rheum turkestanicum. Biomed Pharmacother 2022;148:112775. https:\/\/doi.org\/10.1016\/j.biopha.2022.112775.","DOI":"10.1016\/j.biopha.2022.112775"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_080","doi-asserted-by":"crossref","unstructured":"Braumann, S, Baldus, S, Pfister, R. Molecular mechanisms underlying cardiotoxicity of novel cancer therapeutics. J\u00a0Thorac Dis 2018;10:S4335\u201343. https:\/\/doi.org\/10.21037\/jtd.2018.10.107.","DOI":"10.21037\/jtd.2018.10.107"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_081","doi-asserted-by":"crossref","unstructured":"Varga, ZV, Ferdinandy, P, Liaudet, L, Pacher, P. Drug-induced mitochondrial dysfunction and cardiotoxicity. Am J Physiol Heart Circ Physiol 2015;309:H1453\u201367. https:\/\/doi.org\/10.1152\/ajpheart.00554.2015.","DOI":"10.1152\/ajpheart.00554.2015"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_082","doi-asserted-by":"crossref","unstructured":"Mamoshina, P, Rodriguez, B, Bueno-Orovio, A. Toward a broader view of mechanisms of drug cardiotoxicity. Cell Rep Med 2021;2:100216. https:\/\/doi.org\/10.1016\/j.xcrm.2021.100216.","DOI":"10.1016\/j.xcrm.2021.100216"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_083","doi-asserted-by":"crossref","unstructured":"Mlad\u011bnka, P, Applov\u00e1, L, Pato\u010dka, J, Costa, VM, Remiao, F, Pourov\u00e1, J, et al.. Comprehensive review of cardiovascular toxicity of drugs and related agents. Med Res Rev 2018;38:1332\u2013403. https:\/\/doi.org\/10.1002\/med.21476.","DOI":"10.1002\/med.21476"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_084","doi-asserted-by":"crossref","unstructured":"Perez, IE, Taveras Alam, S, Hernandez, GA, Sancassani, R. Cancer therapy-related cardiac dysfunction: an overview for the clinician. Clin Med Insights Cardiol 2019;13:1179546819866445. https:\/\/doi.org\/10.1177\/1179546819866445.","DOI":"10.1177\/1179546819866445"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_085","doi-asserted-by":"crossref","unstructured":"Perez, EA, Romond, EH, Suman, VJ, Jeong, J, Davidson, NE, Geyer, CE, et al.. Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with\/without trastuzumab in patients with HER2-positive breast cancer. J\u00a0Clin Oncol 2007;25:512. https:\/\/doi.org\/10.1200\/jco.2007.25.18_suppl.512.","DOI":"10.1200\/jco.2007.25.18_suppl.512"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_086","unstructured":"Baker, DE. Loperamide: a pharmacological review. Rev Gastroenterol Disord 2007;7:S11\u201318."},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_087","doi-asserted-by":"crossref","unstructured":"Massoomi, F, Savage, J, Destache, CJ. Omeprazole: a comprehensive review. Pharmacotherapy 1993;13:46\u201359. https:\/\/doi.org\/10.1002\/j.1875-9114.1993.tb02689.x.","DOI":"10.1002\/j.1875-9114.1993.tb02689.x"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_088","doi-asserted-by":"crossref","unstructured":"Zwartsen, A, De Korte, T, Nacken, P, De Lange, DW, Westerink, RHS, Hondebrink, L. Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings. J\u00a0Mol Cell Cardiol 2019;136:102\u201312. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.09.007.","DOI":"10.1016\/j.yjmcc.2019.09.007"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_089","doi-asserted-by":"crossref","unstructured":"Hondebrink, L, Nugteren-van Lonkhuyzen, JJ, Rietjens, SJ, Brunt, TM, Venhuis, B, Soerdjbalie-Maikoe, V, et al.. Fatalities, cerebral hemorrhage, and severe cardiovascular toxicity after exposure to the new psychoactive substance 4-Fluoroamphetamine: a prospective cohort study. Ann Emerg Med 2018;71:294\u2013305. https:\/\/doi.org\/10.1016\/j.annemergmed.2017.07.482.","DOI":"10.1016\/j.annemergmed.2017.07.482"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_090","doi-asserted-by":"crossref","unstructured":"Weill, A, Pa\u00efta, M, Tuppin, P, Fagot, J, Neumann, A, Simon, D, et al.. Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. Pharmacoepidemiol Drug Saf 2010;19:1256\u201362. https:\/\/doi.org\/10.1002\/pds.2044.","DOI":"10.1002\/pds.2044"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_091","doi-asserted-by":"crossref","unstructured":"Aurora, L, McCord, J. Drugs to avoid in acute decompensated heart failure (ADHF): contraindicated medications and interactions. In: WF Peacock, editor, in Contemporary Cardiology. Short stay management of acute heart failure. Cham: Springer International Publishing; 2017:261\u20138 pp.","DOI":"10.1007\/978-3-319-44006-4_20"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_092","doi-asserted-by":"crossref","unstructured":"Armenian, SH, Lacchetti, C, Barac, A, Carver, J, Constine, LS, Denduluri, N, et al.. Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American society of Clinical Oncology Clinical Practice Guideline. J\u00a0Clin Oncol 2017;35:893\u2013911. https:\/\/doi.org\/10.1200\/JCO.2016.70.5400.","DOI":"10.1200\/JCO.2016.70.5400"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_093","doi-asserted-by":"crossref","unstructured":"Marsico, F, Gargiulo, P, Marra, AM, Parente, A, Paolillo, S. Glucose metabolism abnormalities in heart failure patients. Heart Fail Clin 2019;15:333\u201340. https:\/\/doi.org\/10.1016\/j.hfc.2019.02.002.","DOI":"10.1016\/j.hfc.2019.02.002"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_094","doi-asserted-by":"crossref","unstructured":"Salzano, A, Marra, AM, D\u2019Assante, R, Arcopinto, M, Suzuki, T, Bossone, E, et al.. Growth hormone therapy in heart failure. Heart Fail Clin 2018;14:501\u201315. https:\/\/doi.org\/10.1016\/j.hfc.2018.05.002.","DOI":"10.1016\/j.hfc.2018.05.002"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_095","doi-asserted-by":"crossref","unstructured":"Tiwari, R, Siddiqui, MH, Mahmood, T, Farooqui, A, Bagga, P, Ahsan, F, et al.. An exploratory analysis on the toxicity & safety profile of polyherbal combination of curcumin, quercetin and rutin. Clin Phytosci 2020;6:82. https:\/\/doi.org\/10.1186\/s40816-020-00228-2.","DOI":"10.1186\/s40816-020-00228-2"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_096","doi-asserted-by":"crossref","unstructured":"Caporali, S, De Stefano, A, Calabrese, C, Giovannelli, A, Pieri, M, Savini, I, et al.. Anti-inflammatory and active biological properties of the plant-derived bioactive compounds luteolin and luteolin 7-Glucoside. Nutrients 2022;14:1155. https:\/\/doi.org\/10.3390\/nu14061155.","DOI":"10.3390\/nu14061155"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_097","doi-asserted-by":"crossref","unstructured":"Giampetruzzi, A, Chiumenti, M, Saponari, M, Donvito, G, Italiano, A, Loconsole, G, et al.. Draft genome sequence of the Xylella fastidiosa CoDiRO strain. Genome Announc 2015;3:e01538\u201314. https:\/\/doi.org\/10.1128\/genomeA.01538-14.","DOI":"10.1128\/genomeA.01538-14"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_098","doi-asserted-by":"crossref","unstructured":"Adib, A, Shadmand, MB, Shamsi, P, Afridi, KK, Amirabadi, M, Fateh, F, et al.. E-Mobility\u00a0\u2013\u00a0advancements and challenges. IEEE Access 2019;7:165226\u201340. https:\/\/doi.org\/10.1109\/ACCESS.2019.2953021.","DOI":"10.1109\/ACCESS.2019.2953021"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_099","doi-asserted-by":"crossref","unstructured":"Li, J, Lai, S, Gao, GF, Shi, W. The emergence, genomic diversity and global spread of SARS-CoV-2. Nature 2021;600:408\u201318. https:\/\/doi.org\/10.1038\/s41586-021-04188-6.","DOI":"10.1038\/s41586-021-04188-6"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_100","doi-asserted-by":"crossref","unstructured":"Orji, A, Kamenov, K, Dirac, M, Davis, A, Chadha, S, Vos, T. Global and regional needs, unmet needs and access to hearing aids. Int J Audiol 2020;59:166\u201372. https:\/\/doi.org\/10.1080\/14992027.2020.1721577.","DOI":"10.1080\/14992027.2020.1721577"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_101","doi-asserted-by":"crossref","unstructured":"Owumi, S, Lewu, D, Arunsi, U, Oyelere, A. Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis. Hum Exp Toxicol 2021;40:1656\u201372. https:\/\/doi.org\/10.1177\/09603271211006171.","DOI":"10.1177\/09603271211006171"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_102","doi-asserted-by":"crossref","unstructured":"Mignard, F, Klioner, SA, Lindegren, L, Hern\u00e1ndez, J, Bastian, U, Bombrun, A, et al.. Gaia data release 2: summary of the contents and survey properties. Astron Astrophys 2018;616:A1. https:\/\/doi.org\/10.1051\/0004-6361\/201833051.","DOI":"10.1051\/0004-6361\/201833051"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_103","doi-asserted-by":"crossref","unstructured":"Bertero, E, Maack, C. Calcium signaling and reactive oxygen species in mitochondria. Circ Res 2018;122:1460\u201378. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.310082.","DOI":"10.1161\/CIRCRESAHA.118.310082"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_104","doi-asserted-by":"crossref","unstructured":"Ryter, SW, Kim, HP, Hoetzel, A, Park, JW, Nakahira, K, Wang, X, et al.. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 2007;9:49\u201389. https:\/\/doi.org\/10.1089\/ars.2007.9.49.","DOI":"10.1089\/ars.2007.9.49"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_105","doi-asserted-by":"crossref","unstructured":"Bock, FJ, Tait, SWG. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol 2020;21:85\u2013100. https:\/\/doi.org\/10.1038\/s41580-019-0173-8.","DOI":"10.1038\/s41580-019-0173-8"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_106","doi-asserted-by":"crossref","unstructured":"Cui, Z, Zhang, H, Chen, X, Zhang, C, Ma, W, Huang, C, et al.. Pursuing sustainable productivity with millions of smallholder farmers. Nature 2018;555:363\u20136. https:\/\/doi.org\/10.1038\/nature25785.","DOI":"10.1038\/nature25785"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_107","doi-asserted-by":"crossref","unstructured":"Swaminathan, A, Basu, M, Bekri, A, Drapeau, P, Kundu, TK. The dietary flavonoid, luteolin, negatively affects neuronal differentiation. Front Mol Neurosci 2019;12:41. https:\/\/doi.org\/10.3389\/fnmol.2019.00041.","DOI":"10.3389\/fnmol.2019.00041"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_108","doi-asserted-by":"crossref","unstructured":"Wang, Z, Zeng, M, Wang, Z, Qin, F, Chen, J, He, Z. Dietary luteolin: a narrative review focusing on its pharmacokinetic properties and effects on glycolipid metabolism. J\u00a0Agric Food Chem 2021;69:1441\u201354. https:\/\/doi.org\/10.1021\/acs.jafc.0c08085.","DOI":"10.1021\/acs.jafc.0c08085"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_109","doi-asserted-by":"crossref","unstructured":"Madhesh, M, Vaiyapuri, M. Effect of luteolin on lipid peroxidation and antioxidants in acute and chronic periods of isoproterenol induced myocardial infarction in rats. J.\u00a0Acute Med 2012;2:70\u20136. https:\/\/doi.org\/10.1016\/j.jacme.2012.06.001.","DOI":"10.1016\/j.jacme.2012.06.001"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_110","doi-asserted-by":"crossref","unstructured":"Yan, M, Shu, S, Guo, C, Tang, C, Dong, Z. Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury. Ann Med 2018;50:381\u201390. https:\/\/doi.org\/10.1080\/07853890.2018.1489142.","DOI":"10.1080\/07853890.2018.1489142"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_111","doi-asserted-by":"crossref","unstructured":"Najjar, RS, Feresin, RG. Protective role of polyphenols in heart failure: molecular targets and cellular mechanisms underlying their therapeutic potential. Int J Mol Sci 2021;22:1668. https:\/\/doi.org\/10.3390\/ijms22041668.","DOI":"10.3390\/ijms22041668"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_112","doi-asserted-by":"crossref","unstructured":"Hu, W, Xu, T, Wu, P, Pan, D, Chen, J, Chen, J, et al.. Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a. Sci Rep 2017;7:41017. https:\/\/doi.org\/10.1038\/srep41017.","DOI":"10.1038\/srep41017"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_113","doi-asserted-by":"crossref","unstructured":"Motohashi, H, Yamamoto, M. Nrf2\u2013Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 2004;10:549\u201357. https:\/\/doi.org\/10.1016\/j.molmed.2004.09.003.","DOI":"10.1016\/j.molmed.2004.09.003"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_114","doi-asserted-by":"crossref","unstructured":"Zhang, Y-C, Gan, F-F, Shelar, SB, Ng, K-Y, Chew, E-H. Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia hance, provide neuroprotective effects against ischemia-induced cellular injury. Food Chem Toxicol 2013;59:272\u201380. https:\/\/doi.org\/10.1016\/j.fct.2013.05.058.","DOI":"10.1016\/j.fct.2013.05.058"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_115","doi-asserted-by":"crossref","unstructured":"Kim, S, Chin, Y-W, Cho, J. Protection of cultured cortical neurons by luteolin against oxidative damage through inhibition of apoptosis and induction of Heme Oxygenase-1. Biol Pharm Bull 2017;40:256\u201365. https:\/\/doi.org\/10.1248\/bpb.b16-00579.","DOI":"10.1248\/bpb.b16-00579"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_116","doi-asserted-by":"crossref","unstructured":"Xu, T, Li, D, Jiang, D. Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following Ischemia\/reperfusion. Nutrients 2012;4:2008\u201319. https:\/\/doi.org\/10.3390\/nu4122008.","DOI":"10.3390\/nu4122008"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_117","doi-asserted-by":"crossref","unstructured":"Zhang, N, Wei, W-Y, Li, L-L, Hu, C, Tang, Q-Z. Therapeutic potential of polyphenols in cardiac fibrosis. Front Pharmacol 2018;9:122. https:\/\/doi.org\/10.3389\/fphar.2018.00122.","DOI":"10.3389\/fphar.2018.00122"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_118","doi-asserted-by":"crossref","unstructured":"Ghio, S, Acquaro, M, Agostoni, P, Ambrosio, G, Carluccio, E, Castiglione, V, et al.. Right heart failure in left heart disease: imaging, functional, and biochemical aspects of right ventricular dysfunction. Heart Fail Rev 2022;28:1009\u201322. https:\/\/doi.org\/10.1007\/s10741-022-10276-0.","DOI":"10.1007\/s10741-022-10276-0"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_119","doi-asserted-by":"crossref","unstructured":"Pan, Q, Liu, Y, Ma, W, Kan, R, Zhu, H, Li, D. Cardioprotective effects and possible mechanisms of luteolin for myocardial ischemia-reperfusion injury: a systematic review and meta-analysis of preclinical evidence. Front Cardiovasc Med 2022;9. https:\/\/doi.org\/10.3389\/fcvm.2022.685998.","DOI":"10.3389\/fcvm.2022.685998"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_120","doi-asserted-by":"crossref","unstructured":"Zhang, Y, Ma, C, Liu, C, Wei, F. Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1\/AKT\/Bcl-2 signalling pathway. PeerJ 2020;8:e8845. https:\/\/doi.org\/10.7717\/peerj.8845.","DOI":"10.7717\/peerj.8845"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_121","doi-asserted-by":"crossref","unstructured":"Zhao, L, Zhou, Z, Zhu, C, Fu, Z, Yu, D. Luteolin alleviates myocardial ischemia reperfusion injury in rats via Siti1\/NLRP3\/NF-\u03baB pathway. Int Immunopharmacol 2020;85:106680. https:\/\/doi.org\/10.1016\/j.intimp.2020.106680.","DOI":"10.1016\/j.intimp.2020.106680"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_122","doi-asserted-by":"crossref","unstructured":"Qi, Y, Fu, S, Pei, D, Fang, Q, Xin, W, Yuan, X, et al.. Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1\/Nrf2 signaling pathway. Free Radic Res 2022;56:209\u201321. https:\/\/doi.org\/10.1080\/10715762.2022.2067042.","DOI":"10.1080\/10715762.2022.2067042"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_123","doi-asserted-by":"crossref","unstructured":"Zhang, Y, Ma, C, Liu, C, Wei, F. Luteolin attenuates doxorubicin-induced cardiotoxicity by modulating the PHLPP1\/AKT\/Bcl-2 signalling pathway. PeerJ 2020;8:e8845. https:\/\/doi.org\/10.7717\/peerj.8845.","DOI":"10.7717\/peerj.8845"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_124","doi-asserted-by":"crossref","unstructured":"Luo, Y, Shang, P, Li, D. Luteolin: a flavonoid that has multiple cardio-protective effects and its molecular mechanisms. Front Pharmacol 2017;8. https:\/\/doi.org\/10.3389\/fphar.2017.00692.","DOI":"10.3389\/fphar.2017.00692"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_125","doi-asserted-by":"crossref","unstructured":"Wan, C, Liang, Q, Ma, Y, Wang, Y, Sun, L, Lai, J, et al.. Luteolin: a natural product with multiple mechanisms for atherosclerosis. Front Pharmacol 2025;16:1503832. https:\/\/doi.org\/10.3389\/fphar.2025.1503832.","DOI":"10.3389\/fphar.2025.1503832"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_126","doi-asserted-by":"crossref","unstructured":"Liang, Y, Sun, B, Yang, M, Meng, X, Wang, M, Yang, L, et al.. Evaluation of luteolin nanosuspensions on pharmacokinetics of atorvastatin: drug-drug interactions using rat models. Int J Nanomed 2025;20:2557\u201373, https:\/\/doi.org\/10.2147\/IJN.S492141.","DOI":"10.2147\/IJN.S492141"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_127","doi-asserted-by":"crossref","unstructured":"Zhu, M, Sun, Y, Su, Y, Guan, W, Wang, Y, Han, J, et al.. Luteolin: a promising multifunctional natural flavonoid for human diseases. Phytother Res 2024;38:3417\u201343. https:\/\/doi.org\/10.1002\/ptr.8217.","DOI":"10.1002\/ptr.8217"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_128","doi-asserted-by":"crossref","unstructured":"De Souza, P, Da Silva, LM, De Andrade, SF, Gasparotto Junior, A. Recent advances in the knowledge of naturally-derived bioactive compounds as modulating agents of the renin-angiotensin-aldosterone system: therapeutic benefits in cardiovascular diseases. Curr Pharm Des 2019;25:670\u201384. https:\/\/doi.org\/10.2174\/1381612825666190329122443.","DOI":"10.2174\/1381612825666190329122443"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_129","doi-asserted-by":"crossref","unstructured":"Schiattarella, GG, Hill, JA. Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload. Circulation 2015;131:1435\u201347. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.115.013894.","DOI":"10.1161\/CIRCULATIONAHA.115.013894"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_130","doi-asserted-by":"crossref","unstructured":"Sindhu, RK, Goyal, A, Alg\u0131n Yapar, E, Cavalu, S. Bioactive compounds and nanodelivery perspectives for treatment of cardiovascular diseases. Appl Sci 2021;11:11031. https:\/\/doi.org\/10.3390\/app112211031.","DOI":"10.3390\/app112211031"},{"key":"2026092511253995575_j_jbcpp-2026-0104_ref_131","doi-asserted-by":"crossref","unstructured":"Liu, C, Wang, P, Gu, R, Zhao, K, Gao, Y, Tang, B, et al.. Nanodelivery of bioactive natural products: a targeted therapeutic breakthrough for atherosclerosis. Pharmaceutics 2025;17:1102. https:\/\/doi.org\/10.3390\/pharmaceutics17091102.","DOI":"10.3390\/pharmaceutics17091102"}],"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2026-0104\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2026-0104\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:26:40Z","timestamp":1790335600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2026-0104\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":131,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,8,17]]},"published-print":{"date-parts":[[2026,9,25]]}},"alternative-id":["10.1515\/jbcpp-2026-0104"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2026-0104","relation":{},"ISSN":["0792-6855","2191-0286"],"issn-type":[{"value":"0792-6855","type":"print"},{"value":"2191-0286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}