{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:46:43Z","timestamp":1777290403854,"version":"3.51.4"},"reference-count":16,"publisher":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction<\/jats:bold>\n                    :\n                    <jats:italic>Cupriavidus pauculus<\/jats:italic>\n                    is a rarely isolated non-fermentative, aerobic bacillus, which occasionally causes severe human infections, especially in immunocompromised patients. Strains have been isolated from various clinical and environmental sources.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case presentation<\/jats:bold>\n                    : A 67-year-old man was admitted to the Intensive Care Unit with acute respiratory failure. The patient was diagnosed with bilateral pneumonia, pulmonary sepsis and underwent invasive mechanical ventilation. Examination revealed diminished bilateral vesicular breath sounds, fever, intense yellow tracheal secretions, a respiratory rate of 24\/minute, a heart rate of 123\/minute, and blood pressure of 75\/55 mmHg. Vasoactive treatment was initiated. Investigations revealed elevated lactate and C-reactive protein levels. A chest X-ray showed bilateral infiltration. Parenteral ciprofloxacin and ceftriaxone were administered. Tracheal aspirate culture and blood culture showed bacterial growth of Cupriavidus pauculus. Colistin was added to the treatment. There was a poor clinical response despite repeated blood culture showing negative results. The diagnosis of multiple organ dysfunction syndrome (MODS) caused by C. pauculus was made. The patient died eleven days after admission.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Clinical improvement cannot always be expected in spite of targeted antibiotic therapy. This pathogen should be considered responsible for infections that usually develop in immunocompromised patients.\n                  <\/jats:p>","DOI":"10.1515\/jccm-2016-0027","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T05:04:35Z","timestamp":1478667875000},"page":"201-204","source":"Crossref","is-referenced-by-count":17,"title":["A Fatal Case of Community Acquired\n                    <i>Cupriavidus Pauculus<\/i>\n                    Pneumonia"],"prefix":"10.62838","volume":"2","author":[{"given":"Emoke","family":"Almasy","sequence":"first","affiliation":[{"name":"Discipline of Intensive Care, University of Medicine and Pharmacy T\u00eergu Mure\u015f, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Szederjesi","sequence":"additional","affiliation":[{"name":"Discipline of Intensive Care, University of Medicine and Pharmacy T\u00eergu Mure\u015f, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Rad","sequence":"additional","affiliation":[{"name":"Discipline of Intensive Care, University of Medicine and Pharmacy T\u00eergu Mure\u015f, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases, University of Medicine and Pharmacy T\u00eergu Mure\u015f, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49540","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"2021040806340957940_j_jccm-2016-0027_ref_001_w2aab2b8b7b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801-10. doi: 10.1001\/jama.2016.0287.","DOI":"10.1001\/jama.2016.0287"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_002_w2aab2b8b7b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. Copotoiu SM, Copotoiu R. Much Ado About the New Definitions of Sepsis. J Crit Care Med. 2016;2:67-72. DOI: 10.1515\/jccm-2016-0015.","DOI":"10.1515\/jccm-2016-0015"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_003_w2aab2b8b7b1b7b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. Duggal S, Gur R, Nayar R, Rongpharpi SR, Jain D, Gupta RK. Cupriavidus pauculus (Ralstoniapaucula) concomitant meningitis and septicemia in a neonate: First case report from India. Indian J Med Microbiol. 2013;31:405-9. doi: 10.4103\/0255-0857.118871.","DOI":"10.4103\/0255-0857.118871"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_004_w2aab2b8b7b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. Yabuuchi E, Kosako Y, Yano I, Hotta H, Nishiuchi Y. Transfer of two Burkholderia and an Alcaligenes species to Ralstonia gen. nov.: proposal of Ralstonia pickettii (Ralston, Palleroni and Doudoroff 1973) comb. nov., Ralstonia solanacearum (Smith 1896) comb. nov. and Ralstonia eutropha (Davis 1969) comb. Microbiol Immunol. 1995;39:897-904.","DOI":"10.1111\/j.1348-0421.1995.tb03275.x"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_005_w2aab2b8b7b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. Vandamme P, Goris J, Coenye T, et al. Assignment of Centers for Disease Control group IVc-2 to the genus Ralstonia as Ralstoniapaucula sp. Int J Syst Bacteriol. 1999;49 Pt 2:663-9. DOI: 10.1099\/00207713-49-2-663.","DOI":"10.1099\/00207713-49-2-663"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_006_w2aab2b8b7b1b7b1ab1ab6Aa","unstructured":"6. Mahon CR, Lehman DC, Manuselis G Jr. Textbook of Diagnostic Microbiology. Fourth Edition. Missouri: Maryland Heights. 2011, pp. 499."},{"key":"2021040806340957940_j_jccm-2016-0027_ref_007_w2aab2b8b7b1b7b1ab1ab7Aa","unstructured":"7. Ta\u015fbakan MS, Yamazhan T, Aydemir S, Bacako\u011flu F. A case of ventilator-associated pneumonia caused by Cupriavidus pauculus. Mikrobiyol Bul. 2010;44:127-31."},{"key":"2021040806340957940_j_jccm-2016-0027_ref_008_w2aab2b8b7b1b7b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. Aspinall, ST, Graham R. Two sources of contamination of a hydrotherapy pool by environmental organisms. J Hosp Infect. 1989;14:285-92.","DOI":"10.1016\/0195-6701(89)90068-6"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_009_w2aab2b8b7b1b7b1ab1ab9Aa","doi-asserted-by":"crossref","unstructured":"9. Uzodi AS, Schears GJ, Neal JR, Henry NK. Cupriavidus pauculus bacteremia in a child on extracorporeal membrane oxygenation. ASAIO J. 2014;60:740-1. doi: 10.1097\/MAT.0000000000000120.","DOI":"10.1097\/MAT.0000000000000120"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_010_w2aab2b8b7b1b7b1ab1ac10Aa","doi-asserted-by":"crossref","unstructured":"10. Foxman B. Molecular Tools and Infectious Disease Epidemiology. California: San Diego. 2012, pp. 173.","DOI":"10.1016\/B978-0-12-374133-2.00006-X"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_011_w2aab2b8b7b1b7b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. Aydin B, Dilli D, Zenciro\u011flu A, Okumu\u015f N, Ozkan S, Tanir G. A case of newborn with community acquired pneumonia caused by Cupriavidus pauculus. Tuberk Toraks. 2012;60:160-2.","DOI":"10.5578\/tt.3496"},{"key":"2021040806340957940_j_jccm-2016-0027_ref_012_w2aab2b8b7b1b7b1ab1ac12Aa","doi-asserted-by":"crossref","unstructured":"12. 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