{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:46:42Z","timestamp":1777290402957,"version":"3.51.4"},"reference-count":32,"publisher":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Staphylococcal scalded skin syndrome (SSSS) is the medical term used to define a skin condition induced by the exfoliative toxins produced by Staphylococcus aureus. The disorder is also known as Ritter disease, bullous impetigo, neonatal pemphigus, or staphylococcal scarlet fever. The disease especially affects infants and small children, but has also been described in adults. Prompt therapy with proper antibiotics and supportive treatment has led to a decrease in the mortality rate.<\/jats:p>\n                  <jats:p>The current case report describes the clinical progress of a patient with generalized erythema and fever, followed by the appearance of bullous lesions with tendency to rupture under the smallest pressure, and with extended areas of denudation.<\/jats:p>\n                  <jats:p>The patient aged four years and six months was admitted to our clinic to establish the aetiology and treatment of a generalized bullous exanthema, followed by a skin denudation associated with fever and impaired general status.<\/jats:p>\n                  <jats:p>Based on clinical and paraclinical examinations a diagnosis of Staphylococcal scalded skin syndrome was established which responded favourably to antibiotic treatment, hydro-electrolytic re-equilibration, and adequate local hygiene.<\/jats:p>\n                  <jats:p>Staphylococcal infection can represent a problem of significant pathological importance sometimes requiring a multidisciplinary approach involving paediatricians, dermatologists, infectious diseases specialists, and plastic surgeons.<\/jats:p>","DOI":"10.1515\/jccm-2016-0028","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T05:04:35Z","timestamp":1478667875000},"page":"192-197","source":"Crossref","is-referenced-by-count":7,"title":["Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature"],"prefix":"10.62838","volume":"2","author":[{"given":"Alina","family":"Grama","sequence":"first","affiliation":[{"name":"Pediatrics I Department, University of Medicine and Pharmacy T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Cristina","family":"M\u0103rginean","sequence":"additional","affiliation":[{"name":"Pediatrics I Department, University of Medicine and Pharmacy T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Elena","family":"Meli\u021b","sequence":"additional","affiliation":[{"name":"Pediatrics I Department, University of Medicine and Pharmacy T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca Meda","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University of Medicine and Pharmacy T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49540","published-online":{"date-parts":[[2016,11,8]]},"reference":[{"key":"2021040615452948827_j_jccm-2016-0028_ref_001_w2aab2b8b4b1b7b1ab1ab1Aa","unstructured":"1. Adhisivam B, Mahadevan S. Abscess of the nasal septum with staphylococcal scalded skin syndrome. Indian Pediatr. 2006;43:372-3."},{"key":"2021040615452948827_j_jccm-2016-0028_ref_002_w2aab2b8b4b1b7b1ab1ab2Aa","unstructured":"2. Popescu V. Infec\u021biile stafilococice la copil. Revista Rom\u00e2n\u0103 de Pediatrie. 2008;2:105-114."},{"key":"2021040615452948827_j_jccm-2016-0028_ref_003_w2aab2b8b4b1b7b1ab1ab3Aa","unstructured":"3. Menon NS. Staphylococcal scalded skin syndrome. A case series with review of literature. IAIM. 2015;2:214-9."},{"key":"2021040615452948827_j_jccm-2016-0028_ref_004_w2aab2b8b4b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. Saida K, Kawasaki K, Hirabayashi K, et al. Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants. Eur J Pediatr. 2015;174:551-5. doi: 10.1007\/s00431-014-2414-3.","DOI":"10.1007\/s00431-014-2414-3"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_005_w2aab2b8b4b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. Blyth M, Estela C, Young AE, et al. Severe staphylococcal scalded syndrome in children. Burns. 2008;34:98\u2013103. DOI: 10.1016\/j.burns.2007.02.006","DOI":"10.1016\/j.burns.2007.02.006"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_006_w2aab2b8b4b1b7b1ab1ab6Aa","doi-asserted-by":"crossref","unstructured":"6. Rydzewska-Rosolowska A, Brzosko S, Borawski J, Mysliwiec M. Staphylococcal scalded skin syndrome in the course of lupus nephritis. Nephrology (Carlton). 2008;13:265-66. doi: 10.1111\/j.1440-1797.2007.00904.x.","DOI":"10.1111\/j.1440-1797.2007.00904.x"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_007_w2aab2b8b4b1b7b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. Yamasaki O, Takayuki Y, Motoyuki S, et al. Clinical manifestations of Staphylococcal Scalded-Skin Syndrome depend on serotypes of exfoliative toxins. J Clin Microbiol. 2005;43:1890-3. DOI: 10.1128\/JCM.43.4.1890-1893.2005","DOI":"10.1128\/JCM.43.4.1890-1893.2005"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_008_w2aab2b8b4b1b7b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. Norbury WB, Gallagher JJ, Herndon DN, Branski LK, Oehring PE, Jeschke MG. Neonate twin with staphylococcal scalded skin syndrome from a renal source. Pediatr Crit Care Med. 2010;11:e20-3. doi: 10.1097\/PCC.0b013e3181b80dd2.","DOI":"10.1097\/PCC.0b013e3181b80dd2"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_009_w2aab2b8b4b1b7b1ab1ab9Aa","doi-asserted-by":"crossref","unstructured":"9. Handler MZ, Schwartz RA. Staphylococcal scalded skin syndrome: diagnosis and management in children and adults. 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Am J Clin Dermatol. 2003;4:165-75.","DOI":"10.2165\/00128071-200304030-00003"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_018_w2aab2b8b4b1b7b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. Duijsters CE, Halbertsma FJ, Kornelisse RF, Arents NL, Andriessen P. Recurring staphylococcal scalded skin syndrome in a very low birth weight infant: a case report. J Med Case Rep. 2009;3:7313. doi: 10.4076\/1752-1947-3-7313.","DOI":"10.4076\/1752-1947-3-7313"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_019_w2aab2b8b4b1b7b1ab1ac19Aa","doi-asserted-by":"crossref","unstructured":"19. Paranthaman K, Bentley A, Milne LM, et al. Nosocomial outbreak of staphyloccocal scalded skin syndrome in neonates in England, December 2012 to March 2013. Euro Surveill. 2014;19:20880.","DOI":"10.2807\/1560-7917.ES2014.19.33.20880"},{"key":"2021040615452948827_j_jccm-2016-0028_ref_020_w2aab2b8b4b1b7b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. 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