{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:40:27Z","timestamp":1793292027695,"version":"4.5.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Complementary and Integrative Medicine"],"abstract":"<jats:p>\n                    <jats:bold>Abstract<\/jats:bold>\n                    :\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    is a semi-tropical plant of Liliaceae family which has a wide range of applications in traditional medicine. In the present study, we sought to investigate the heptaoprotective potential of\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    gel as a diet supplement. To achieve this goal, we have designed\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experimental models of chemical-induced liver damage using male Sprague\u2013Dawley rat. In the\n                    <jats:italic>in vitro<\/jats:italic>\n                    model, its effect was evaluated on Fenton\u2019s reaction-induced liver lipid peroxidation. Co-incubation with gel significantly reduced the generation of liver lipid peroxide (LPO). Next, to see the similar effect\n                    <jats:italic>in vivo<\/jats:italic>\n                    , gel was orally administered to rats once daily for 21 successive days. Following 1 hour of the last administration of gel, rats were treated with intra-peritoneal injection of CCl\n                    <jats:sub>4<\/jats:sub>\n                    . Dietary gel showed significant hepatoprotection against CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced damage as evident by restoration of liver LPO, serum transaminases, alkaline phosphatase, and total bilirubin towards near normal. The beneficial effects were pronounced with the doses used (400 and 800 mg\/kg body weight). Besides, we did not observe any significant drop in serum albumin, globulin as well as total protein levels of gel-administered rats. Histopathology of the liver tissue further supported the biochemical findings confirming the hepatoprotective potential of dietary gel.\n                  <\/jats:p>","DOI":"10.1515\/jcim-2012-0020","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T07:26:15Z","timestamp":1367825175000},"page":"47-53","source":"Crossref","is-referenced-by-count":12,"title":["<i>Aloe vera<\/i>\n                    gel protects liver from oxidative stress-induced damage in experimental rat model"],"prefix":"10.1515","volume":"10","author":[{"given":"Taslima","family":"Nahar","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Savar, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borhan","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Savar, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahdat","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Savar, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Mannan","family":"Sikder","sequence":"additional","affiliation":[{"name":"Department of Pathology, Enam Medical College, Dhaka, Savar, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Savar, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"2025121209153211244_CIT0001_w2aab3b8c68b1b7b1ab2ab1Aa","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-8741(00)00219-1","article-title":"Hepatoprotective activity of Emblica officinalis and Chyavanaprash","volume":"72","year":"2000","journal-title":"J Ethnopharmacol"},{"key":"2025121209153211244_CIT0002_w2aab3b8c68b1b7b1ab2ab2Aa","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1383-5742(99)00009-5","article-title":"Oxygen and nitrogen are pro-carcinogens. 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