{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:22:09Z","timestamp":1765542129310,"version":"3.48.0"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Different fractions (I\u2013V) of the methanolic leaf extracts of\n                    <jats:italic>Annona senegalensis<\/jats:italic>\n                    were assessed for their anti-snake venom activities. Fractions III neutralized lethal toxicity induced by\n                    <jats:italic>Echis ocellatus<\/jats:italic>\n                    venom and manifested the same potency as the crude extracts against the venom. The anti-snake venom activity of fraction III was clearly shown by the complete abrogation of venom-induced haemorrhage and the 75% record of surviving mice which were injected with a pre-incubate of venom and extract in the ratio 1:30 w\/w after a 24 h. Also, fraction III exhibited a weak inhibitory effect on fibrinogen clotting activity of this venom. The key phytochemicals mediating the activity of this fraction are flavonoids and tannins. The detoxification of this venom by fraction III and the possible mode of action in the pathology of snake envenoming is discussed in this report.\n                  <\/jats:p>","DOI":"10.1515\/jcim-2012-0058","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T08:06:20Z","timestamp":1401177980000},"page":"93-97","source":"Crossref","is-referenced-by-count":13,"title":["Detoxification of\n                    <i>Echis ocellatus<\/i>\n                    venom-induced toxicity by\n                    <i>Annona senegalensis<\/i>\n                    Pers"],"prefix":"10.1515","volume":"11","author":[{"given":"Amlabu","family":"Emmanuel","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Kogi State University, Anyigba, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajagun","family":"Ebinbin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ahmadu Bello University, Zaria, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wandayi","family":"Amlabu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ahmadu Bello University, Zaria, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"key":"2025121209215321895_CIT0001_w2aab2b8b6b1b7b1ab2ab1Aa","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1371\/journal.pmed.0030150","article-title":"Confronting the neglected problem of snakebite envenoming: the need for a global partnership","volume":"3","year":"2006","journal-title":"PLoS Med"},{"volume-title":"Rabies and envenomings: a neglected PublicHealth issue","year":"2007","author":"World Health Organization","key":"2025121209215321895_CIT0002_w2aab2b8b6b1b7b1ab2ab2Aa"},{"key":"2025121209215321895_CIT0003_w2aab2b8b6b1b7b1ab2ab3Aa","first-page":"1591","article-title":"The global burden of snakebite: a literature 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