{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:58:04Z","timestamp":1790870284842,"version":"4.1.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Rheumatoid arthritis is an inflammatory autoimmune disorder.\n                    <jats:italic>Withania somnifera<\/jats:italic>\n                    Dunal (Solanaceae) (WS), is a common medicinal plant used in traditional systems of medicine for the treatment of arthritis, and is an ingredient of anti-arthritic polyherbal formulations such as\n                    <jats:italic>Habb-e-Asgand<\/jats:italic>\n                    <jats:sup>\u00ae<\/jats:sup>\n                    and Arthritin\u2122. In the present study, we evaluated the antioxidant and anti-arthritic activity of aqueous extract of WS root (WSAq) in collagen-induced arthritic (CIA) rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : CIA rats were treated by using three doses of WSAq (100, 200, 300 mg\/kg b. wt., orally) and methotrexate (MTX, 0.25 mg\/kg b. wt. i.p.) as a standard reference drug for 20 days. The anti-arthritic effect was assayed by measuring the arthritic index, autoantibodies such as rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (a-CCP), anti-nuclear antibody (ANA), anti-collagen type II antibody (a-CII) and inflammatory marker like C-reactive protein (CRP). The oxidative stress parameters were also measured.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Treatment with WSAq resulted in a dose-dependent reduction in arthritic index, autoantibodies and CRP (p&lt;0.05) with maximum effect at dose of 300 mg\/kg b. wt. and the results were comparable to that of MTX-treated rats. Similarly, oxidative stress in CIA rats was ameliorated by treatment with different doses of WSAq, as evidenced by a decrease in lipid peroxidation and glutathione-\n                    <jats:italic>S<\/jats:italic>\n                    -transferase activity and an increase in the glutathione content and ferric-reducing ability of plasma (p&lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : The results showed that WSAq exhibited antioxidant and anti-arthritic activity and reduced inflammation in CIA rats and suggests the potential use of this plant in the treatment of arthritis.\n                  <\/jats:p>","DOI":"10.1515\/jcim-2014-0075","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T10:13:43Z","timestamp":1426673623000},"page":"117-125","source":"Crossref","is-referenced-by-count":48,"title":["Effect of\n                    <i>Withania somnifera<\/i>\n                    (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats"],"prefix":"10.1515","volume":"12","author":[{"given":"Mahmood Ahmad","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mythily","family":"Subramaneyaan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pathology, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basu Dev","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafat Sultana","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"2025121209161366726_CIT0001_w2aab2b8c39b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/ar1447","article-title":"Oxidation in rheumatoid arthritis","volume":"6","year":"2004","journal-title":"Arthritis Res 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