{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:54:15Z","timestamp":1773212055169,"version":"3.50.1"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2015-0079_s_006_w2aab3b7b5b1b6b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Berberis vulgaris<\/jats:italic>\n                      L. (BV), commonly known as \u201c\n                      <jats:italic>Aghriss<\/jats:italic>\n                      \u201d in Moroccan pharmacopoeia, is used to cure liver disorders and other diseases. The present study aimed to investigate the protective effect of BV aqueous extract against lead-induced toxicity in mice liver.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2015-0079_s_007_w2aab3b7b5b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty IOPS mice were divided into six groups and were treated as follows: group 1 (normal control) received double distilled water; group 2 (toxic control) received lead acetate (5\u2006mg\/kg body weight\/day) in double distilled water for 40 days; groups 3\u20136 received BV aqueous extract at doses of 25, 50, 100 and 150\u2006mg\/kg body weight , respectively, once daily for 30 days from 11 day after beginning of lead acetate exposure to the end of the experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2015-0079_s_008_w2aab3b7b5b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Toxic control group showed a significant alteration of serum alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), total cholesterol (TC), total bilirubin (TB), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH). Histological assessment of lead-intoxicated mice liver revealed alterations in hepatocytes and focal necrosis. BV treatment significantly prevented lead accumulation, increased ALT, AST, TC, and TB, inhibited lipid peroxidation and protein carbonyls(PCO) formation. Additionally, BV extract normalized the antioxidant enzymes (CAT, SOD and GPx), GSH and architecture of liver tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2015-0079_s_009_w2aab3b7b5b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BV aqueous extract exerts significant hepatoprotective effects against lead-induced oxidative stress and liver dysfunction. The BV effect may be mediated through the enhancement of antioxidant status, lead-chelating abilities and free radicals quenching.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2015-0079","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T05:02:21Z","timestamp":1487048541000},"source":"Crossref","is-referenced-by-count":27,"title":["<i>Berberis vulgaris<\/i>\n                    L. effects on oxidative stress and liver injury in lead-intoxicated mice"],"prefix":"10.1515","volume":"14","author":[{"given":"Jawhar","family":"Laamech","sequence":"first","affiliation":[{"name":"Laboratory of Physiology , Pharmacology and Environmental Health, Faculty of Sciences , DM , USMBA University, Fez 30000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaouad","family":"El-Hilaly","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology , Pharmacology and Environmental Health, Faculty of Sciences , DM , USMBA University, Fez 30000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamadi","family":"Fetoui","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Microbiology and Environmental Health (11ES70), Life Science Department, Sciences Faculty of Sfax , University of Sfax , Sfax , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassine","family":"Chtourou","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Microbiology and Environmental Health (11ES70), Life Science Department, Sciences Faculty of Sfax , University of Sfax , Sfax , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanane","family":"Gouitaa","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology , Pharmacology and Environmental Health, Faculty of Sciences , DM , USMBA University, Fez 30000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Tahraoui","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology , Pharmacology and Environmental Health, Faculty of Sciences , DM , USMBA University, Fez 30000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badiaa","family":"Lyoussi","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology , Pharmacology and Environmental Health, Faculty of Sciences , DM , USMBA University, Fez 30000, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"2025121209252451999_j_jcim-2015-0079_ref_001_w2aab3b7b5b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Mikov Bulat P, Prokes B. 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