{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:56:09Z","timestamp":1774263369271,"version":"3.50.1"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Besides the basic role to flavor and color foods, several health benefits have been attributed to spices. The traditional Cameroonian food \u201cNkui\u201d is prepared using several spices (\n                    <jats:italic>Afrostyrax lepidophyllus<\/jats:italic>\n                    Mildbr.,\n                    <jats:italic>Capsicum frutescens<\/jats:italic>\n                    Linn.,\n                    <jats:italic>Fagara leprieurii<\/jats:italic>\n                    Guill. et Perr.,\n                    <jats:italic>Fagara tessmannii<\/jats:italic>\n                    Engl.,\n                    <jats:italic>Mondia whitei<\/jats:italic>\n                    Hook. F. Skell.,\n                    <jats:italic>Pentadiplandra brazzeana<\/jats:italic>\n                    Baill.,\n                    <jats:italic>Solanum gilo<\/jats:italic>\n                    Raddi.,\n                    <jats:italic>Tetrapleura tetraptera<\/jats:italic>\n                    Taub. and\n                    <jats:italic>Xylopia parviflora<\/jats:italic>\n                    A. Rich. Benthane) that are believed to have a positive impact on the female reproductive physiology. Aiming to determine the potential effect of this food on the female reproductive tract, we evaluated the estrogenic properties of aqueous and ethanol extracts of Nkui using a 3-day uterotrophic assay in ovariectomized (OVX) rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : OVX female Wistar rats were randomly separated in several groups of five animals each and submitted to a 3-day uterotrophic assay (\n                    <jats:italic>per os<\/jats:italic>\n                    ). At the end of treatment, animals were sacrificed and uterus, vagina and mammary gland collected and fixed in 10\u2006% formalin for histological analysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : These extracts increased the uterine wet weight, the uterine and vaginal epithelial heights, and the lumen and diameter of alveoli in the mammary glands. They also altered the estradiol-induced increase of uterine wet weight. The dichloromethane and methanol fractions of the ethanol extract exhibited estrogenic properties as well by increasing uterine and vaginal endpoints.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : These results suggest that the spices of \u201cNkui\u201d contain estrogenic phytoconstituents and this traditional food may be considered as functional.\n                  <\/jats:p>","DOI":"10.1515\/jcim-2015-0096","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T04:57:58Z","timestamp":1458017878000},"page":"151-162","source":"Crossref","is-referenced-by-count":9,"title":["Estrogenic properties of spices of the traditional Cameroonian dish \u201cNkui\u201d in ovariectomized Wistar rats"],"prefix":"10.1515","volume":"13","author":[{"given":"Edwige Nana","family":"Tchoupang","sequence":"first","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvin Benjamin","family":"Ateba","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Zingue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zehl","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liselotte","family":"Krenn","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieudonn\u00e9","family":"Njamen","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"2025121209284533171_j_jcim-2015-0096_ref_001_w2aab2b8c72b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"1. 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