{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:31:32Z","timestamp":1765542692478,"version":"3.48.0"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2015-0111_s_001a_w2aab3b7b2b1b6b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a poly herbal Unani formulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2015-0111_s_002b_w2aab3b7b2b1b6b1aab1c14b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Herein, oxidative stress related parameters as MDA, SOD, GPx and CAT have been estimated in the 21 clinically diagnosed Vitiligo in-patients and subsequently these parameters were evaluated during and after administration of MM therapy and compared with 21 healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2015-0111_s_003c_w2aab3b7b2b1b6b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was significant difference in the parameters viz., SOD (p&lt;0.001) and CAT (p&lt;0.005) activity at the baseline with no statistical significant difference in MDA and GPx activity among Vitiligo subjects and controls. After MM therapy there was no statistical significant difference among the values of these parameters in Vitiligo subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2015-0111_s_004_w2aab3b7b2b1b6b1aab1c14b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that there is imbalance in the oxidant-antioxidant status of Vitiligo subjects and the MM therapy is not found to significantly change the levels of oxidative stress related parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2015-0111","type":"journal-article","created":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T04:05:52Z","timestamp":1576901152000},"source":"Crossref","is-referenced-by-count":0,"title":["Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation \u2013 hospital-based study"],"prefix":"10.1515","volume":"17","author":[{"given":"Towseef Amin","family":"Rafeeqi","sequence":"first","affiliation":[{"name":"Biochemistry Cell and Molecular Biology , Central Research Institute of Unani Medicine , Opp ESI Hospital Erragada , Hyderabad , Telangana 500038 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhat","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Biochemistry Cell and Molecular Biology , Central Research Institute of Unani Medicine , Opp ESI Hospital Erragada , Hyderabad , Telangana 500038 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Waheed","sequence":"additional","affiliation":[{"name":"Biochemistry Cell and Molecular Biology , Central Research Institute of Unani Medicine , Opp ESI Hospital Erragada , Hyderabad , Telangana 500038 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulam Mohammed","family":"Husain","sequence":"additional","affiliation":[{"name":"Biochemistry Cell and Molecular Biology , Central Research Institute of Unani Medicine , Opp ESI Hospital Erragada , Hyderabad , Telangana 500038 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alokananda","family":"Chakraborthy","sequence":"additional","affiliation":[{"name":"Biochemistry Cell and Molecular Biology , Central Research Institute of Unani Medicine , Opp ESI Hospital Erragada , Hyderabad , Telangana 500038 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"2025121209252906108_j_jcim-2015-0111_ref_001_w2aab3b7b2b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Sehgal VN, Srivastava G. Vitiligo: compendium of clinico-epidemilogical features. Indian J Dermatol Venereol Leprol 2007;73:149\u201356.","DOI":"10.4103\/0378-6323.32708"},{"key":"2025121209252906108_j_jcim-2015-0111_ref_002_w2aab3b7b2b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Yildirim M, Baysal V, Inaloz HS, Kesici D, Delibas N. The role of oxidants and antioxidants in generalized vitiligo. J Dermatol 2003;30:104\u20138.","DOI":"10.1111\/j.1346-8138.2003.tb00356.x"},{"key":"2025121209252906108_j_jcim-2015-0111_ref_003_w2aab3b7b2b1b6b1ab2b2b3Aa","unstructured":"Monograph on bars (vitiligo) published by CCRUM. Department of AYUSH, Ministry of Health & Family Welfare, Govt. of India 2006:11\u201314."},{"key":"2025121209252906108_j_jcim-2015-0111_ref_004_w2aab3b7b2b1b6b1ab2b2b4Aa","unstructured":"Clinical studies on bars (vitiligo) published by CCRUM. 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