{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:49:26Z","timestamp":1780051766611,"version":"3.53.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Traditional remedies employ herbal drugs for the treatment of liver ailments and hepatoprotection. Thus, the present study was designed to evaluate the hepatoprotective effect of \u201cextract of\n                    <jats:italic>Anacyclus pyrethrum<\/jats:italic>\n                    Linn\u201d (APE) against antitubercular drug-induced hepatotoxicity in rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : Group I rats (normal control) received vehicle (1\u2006% CMC), while group II rats (hepatotoxic control) isoniazid (INH) plus rifampicin (RIF) each 50\u2006mg\/kg\/day po, for 28 days. Group III, IV and V rats were administered with APE 200, APE 400 and silymarin 100\u2006mg\/kg\/day po, respectively, for 28 days. Concurrently, hepatotoxicity was tried to induce by coadministration of INH and RIF each 50\u2006mg\/kg\/day po for 28 days in group III, IV and V rats. After 24\u2009h of the last dosing, blood was obtained under light anesthesia and the rats were killed. Hepatoprotective effect was assessed by liver weight, relative liver weight and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), serum bilirubin, cholesterol, total protein and albumin levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Group IV rats showed significant (p&lt;0.01) decrease in SGPT, SGOT, ALP, LDH, cholesterol, serum bilirubin, liver weight and relative liver weight Levels, while significant (p&lt;0.01) increase in final body weight (b. wt.), total protein and albumin levels as compared to group II rats. Hepatoprotective effect of APE 400\u2006mg\/kg\/day was comparable to that of silymarin 100\u2006mg\/kg\/day and the hepatic marker levels were also restored. Hepatoprotective effect of APE was well supported by the histopathological results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Hydroalcoholic APE root possesses hepatoprotective activity as it exhibited the protective effect against INH plus RIF-induced hepatotoxicity in rats.\n                  <\/jats:p>","DOI":"10.1515\/jcim-2016-0001","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T07:26:40Z","timestamp":1461223600000},"page":"295-300","source":"Crossref","is-referenced-by-count":21,"title":["Hepatoprotective effect of\n                    <i>Anacyclus pyrethrum<\/i>\n                    Linn. against antitubercular drug-induced hepatotoxicity in SD rats"],"prefix":"10.1515","volume":"13","author":[{"given":"Afreen","family":"Usmani","sequence":"first","affiliation":[{"name":"Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Mujahid","sequence":"additional","affiliation":[{"name":"Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khushtar","sequence":"additional","affiliation":[{"name":"Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefazat H.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Azizur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"2025121209262202353_j_jcim-2016-0001_ref_001_w2aab2b8c65b1b7b1ab2b1b1Aa","unstructured":"1. Jalayer NN, Niakan M, Khodadadi E. Determination of antimicrobial activity of Anacyclus pyrethrum extract against some of the oral bacteria: An in vitro study. J Dent Shiraz Univ Med Sci 2012;13(2):59\u201363."},{"key":"2025121209262202353_j_jcim-2016-0001_ref_002_w2aab2b8c65b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"2. Puri HS. Rasayana: Ayurvedic herbs for longevity and rejuvenation. 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