{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:52:01Z","timestamp":1784861521281,"version":"3.55.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2016-0040_s_007_w2aab3b7c42b1b6b1aab1c13b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The objective of the study was to evaluate the antinociceptive, antipyretic and anti-inflammatory activities of ethanolic extract, methanolic extract and\n                      <jats:italic>n<\/jats:italic>\n                      -hexane and chloroform-soluble fractions of methanolic extract of\n                      <jats:italic>Eria javanica<\/jats:italic>\n                      leaves in animal model (rat and mice).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0040_s_008_w2aab3b7c42b1b6b1aab1c13b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The anti-nociceptive potentials of the extracts were studied using the acetic acid-induced writhing test in mice and the antipyretic activity was investigated using yeast-induced pyrexia in rats. Anti-inflammatory activity test was done on rats at a dose by using carrageenan-induced paw edema test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0040_s_009_w2aab3b7c42b1b6b1aab1c13b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In acetic acid-induced writhing inhibition study in Swiss albino mice, the crude methanolic extract at 200\u2006mg\/kg and 400\u2006mg\/kg doses and the\n                      <jats:italic>n<\/jats:italic>\n                      -hexane soluble fraction of crude methanolic extract at 400\u2006mg\/kg showed statistically significant activity with 53.21\u2006% (p&lt;0.001), 50.36\u2006% (p&lt;0.001) and 67.86\u2006% (p&lt;0.001) inhibition respectively compared to control. The crude ethanolic extract showed statistically significant antipyretic activity from 1 hours and onwards after administration at doses of 200\u2006mg\/kg body weight (p&lt;0.005 at 1st hour and p&lt;0.001 at 2nd, 3rd and 4th hour respectively) and 400\u2006mg\/kg body weight (p&lt;0.05 at 1st hour and p&lt;0.001 at 2nd, 3rd and 4th hour respectively). The crude methanolic extract showed statistically significant antipyretic activity from 2 hours and onwards at 400\u2006mg\/kg body weight (p&lt;0.05 at 2nd hour and p&lt;0.001 at 3rd and 4th hour respectively) and 200\u2006mg\/kg body weight dose showed statistically significant antipyretic activity from 3 hours and onward(p&lt;0.001) in Brewer\u2019s yeast-induced pyrexia test in albino Wister rats. In carrageenan-induced rat\u2019s paw edema test, crude methanolic extract showed statistically significant anti-inflammatory activity from 2nd hour and onwards. The chloroform-soluble fraction of methanolic extract also showed significant activity from 1st hour onwards.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0040_s_010_w2aab3b7c42b1b6b1aab1c13b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study thereby indicates that leaves of\n                      <jats:italic>E. javanica<\/jats:italic>\n                      possess peripheral analgesic, antipyretic and anti-inflammatory activities and therefore a suitable candidate for further study.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2016-0040","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T05:02:46Z","timestamp":1489122166000},"source":"Crossref","is-referenced-by-count":4,"title":["<i>In vivo<\/i>\n                    analgesic, antipyretic and anti-inflammatory potential of leaf extracts and fractions of\n                    <i>Eria javanica<\/i>"],"prefix":"10.1515","volume":"14","author":[{"given":"N. 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