{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:43:15Z","timestamp":1790196195500,"version":"4.1.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2016-0051_s_005_w2aab3b7b5b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d6069e14410_w2aab3b7b5b1b6b1aab1c16b1aAa\">Context<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Emblica officinalis<\/jats:italic>\n                      Gaertn. (family-Phyllanthaceae) fruits, known commonly as amla, is extensively used in Indian traditional system of medicine for the treatment of various disorders. The ethanolic\n                      <jats:italic>E. officinalis<\/jats:italic>\n                      extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0051_s_006_w2aab3b7b5b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d6069e14424_w2aab3b7b5b1b6b1aab1c16b2aAa\">Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate anti-obesity effect of aqueous\n                      <jats:italic>E. officinalis<\/jats:italic>\n                      extract in murine model of high fat diet (HFD)-induced obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0051_s_007_w2aab3b7b5b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d6069e14436_w2aab3b7b5b1b6b1aab1c16b3aAa\">Materials and methods<\/jats:title>\n                    <jats:p>\n                      Male Wistar rats fed with HFD (20 g\/day\/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous\n                      <jats:italic>E. officinalis<\/jats:italic>\n                      extract (20 mg\/kg bw) administered orally to HFD-fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0051_s_008_w2aab3b7b5b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d6069e14448_w2aab3b7b5b1b6b1aab1c16b4aAa\">Results<\/jats:title>\n                    <jats:p>\n                      Oral feeding of the aqueous\n                      <jats:italic>E. officinalis<\/jats:italic>\n                      extract (20 mg\/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0051_s_009_w2aab3b7b5b1b6b1aab1c16b5Aa\">\n                    <jats:title id=\"d6069e14461_w2aab3b7b5b1b6b1aab1c16b5aAa\">Discussion and conclusions<\/jats:title>\n                    <jats:p>\n                      These results show that aqueous\n                      <jats:italic>E. officinalis<\/jats:italic>\n                      extract possess significant anti-obesity potential.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2016-0051","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T17:16:10Z","timestamp":1512494170000},"source":"Crossref","is-referenced-by-count":10,"title":["<i>Emblica officinalis<\/i>\n                    \u2013 Anti-obesity activity"],"prefix":"10.1515","volume":"15","author":[{"given":"Iram","family":"Nazish","sequence":"first","affiliation":[{"name":"Department of Pharmacology , HK College of Pharmacy , Oshiwara , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid H","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy , Hamdard University , Hamdard Nagar , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"2025121209182640699_j_jcim-2016-0051_ref_001_w2aab3b7b5b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Haslam DW, James WPT. 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