{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:00:27Z","timestamp":1781305227253,"version":"3.54.1"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2016-0074_s_006_w2aab3b7b1b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d4490306e463_w2aab3b7b1b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Syzygium guineense<\/jats:italic>\n                      (Myrtaceae) has been used in traditional medicine against various ailments, including diarrhoea. This study was conducted to scientifically evaluate the antidiarrheal effects of\n                      <jats:italic>S. guineense<\/jats:italic>\n                      extract and fractions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0074_s_007_w2aab3b7b1b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d4490306e477_w2aab3b7b1b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>\n                      An ethanol extract of\n                      <jats:italic>S. guineense<\/jats:italic>\n                      leaves was prepared and tested for its effect on small intestinal propulsion in mice and castor oil-induced fluid accumulation in rats. The extract was also evaluated for its effect on itopride-induced small intestine propulsion in mice. Column fractions were also investigated in rats and sub-fractions were tested for activity on spontaneous contractions of isolated rabbit jejunum.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0074_s_008_w2aab3b7b1b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d4490306e489_w2aab3b7b1b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>\n                      The results showed that the extract significantly (p&lt;0.05) inhibited intrinsic small intestinal propulsion and itopride-induced propulsive activity, similar to atropine (0.3\u2009mg\/kg) although its inhibitory effect against castor oil-induced intestinal fluid accumulation and diarrhoea was statistically insignificant (p&gt;0.05). Column separation yielded 14 fractions, with three fractions producing significant (p&lt;0.001) inhibition of small intestinal propulsion. Sub-fractions 1, 7 and 16 obtained from an active column fraction also exhibited relaxant effects on isolated rabbit jejunum. Spectral analysis (proton,\n                      <jats:sup>13<\/jats:sup>\n                      C NMR) of sub-fractions 7 and 16 revealed the presence of betulinic acid, ursolic acid, oleanolic acid in 7 and a mixture of luteolin and friedelane-type triterpenes in 16.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0074_s_009_w2aab3b7b1b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d4490306e501_w2aab3b7b1b1b6b1aab1c16b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings provide scientific evidence that\n                      <jats:italic>S. guineense<\/jats:italic>\n                      leaf extract possess antidiarrhoeal activity and may be potentially beneficial in treatment diarrhoeal disease. The identified compounds may also be implicated in its antidiarrhoeal effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2016-0074","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T05:08:08Z","timestamp":1540616888000},"source":"Crossref","is-referenced-by-count":4,"title":["Antidiarrhoeal properties of\n                    <i>Syzygium guineense<\/i>\n                    leaf extract and identification of chemical constituents in its active column fractions"],"prefix":"10.1515","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-971X","authenticated-orcid":false,"given":"Ifeoma C.","family":"Ezenyi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology , National Institute for Pharmaceutical Research and Development , Abuja , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John O.","family":"Igoli","sequence":"additional","affiliation":[{"name":"Phytochemistry Research Group, Department of Chemistry , University of Agriculture , PMB 2373 , Makurdi , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"2025121209294832611_j_jcim-2016-0074_ref_001_w2aab3b7b1b1b6b1ab1b7b1Aa","unstructured":"World Health Organization. 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