{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:56:10Z","timestamp":1767772570428,"version":"3.48.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2016-0084_s_005_w2aab3b7b3b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d1690857e8869_w2aab3b7b3b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>\n                      The present investigation focuses the diabetes-induced testicular hypofunction and its possible correction by the effective dose of ethyl-acetate fraction of methanolic extract of\n                      <jats:italic>Camellia sinensis<\/jats:italic>\n                      leaves through dose-dependent study in streptozotocin-induced diabetic rat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0084_s_006_w2aab3b7b3b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d1690857e8879_w2aab3b7b3b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>The androgenic, spermiological, oxidative stress and apoptosis sensors along with testicular genomic sensors were evaluated in a dose-dependent fashion (50\u2006mg or 100\u2006mg or 200\u2009mg\/kg body weight). Activities of hepatic transaminases for toxicity assessment were also measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0084_s_007_w2aab3b7b3b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d1690857e8886_w2aab3b7b3b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>Increased level of fasting blood glucose, testicular cholesterol, seminal vesicular fructose along with a low count, motility and viability of epididymal sperm, low activities of testicular \u03945, 3\u03b2-hydroxy steroid dehydrogenase (HSD), 17\u03b2-HSD, testicular antioxidant enzymes (catalase and superoxide dismutase) and low plasma level of testosterone were noted in diabetic rat in respect to the control. After oral administration of said fraction to diabetic rat, levels of above sensors were resettled toward the control. A significant decrease in the number of different generations of germ cells at the stage VII of spermatogenesis in diabetic rat was noted which were recovered significantly toward the control in the fraction-treated diabetic group. It was supported by the correction in gene expression of testicular \u03945, 3\u03b2- HSD, 17\u03b2- HSD, Bcl-2 and Bax in the fraction-treated diabetic group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0084_s_008_w2aab3b7b3b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d1690857e8893_w2aab3b7b3b1b6b1aab1c16b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>\n                      The threshold dose of ethyl-acetate fraction of methanolic extract of\n                      <jats:italic>C. sinensis<\/jats:italic>\n                      leaves is 100\u2009mg\/kg body weight for the recovery of testicular hypofunction in a diabetic rat model.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2016-0084","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T06:01:29Z","timestamp":1503986489000},"source":"Crossref","is-referenced-by-count":8,"title":["Ameliorative role of ethyl-acetate fraction of methanolic leaf extract of\n                    <i>Camellia sinensis<\/i>\n                    (green tea) on streptozotocin-induced diabetes linked testicular hypofunction in albino rat: A dose-dependent biochemical and genomic transection study"],"prefix":"10.1515","volume":"14","author":[{"given":"Barnali","family":"Das","sequence":"first","affiliation":[{"name":"Molecular Medicine & Nutrigenomics Laboratory , Department of Bio-Medical Laboratory Science and Management, Vidyasagar University , Midnapore , West Bengal , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baisakhi","family":"Biswas","sequence":"additional","affiliation":[{"name":"Molecular Medicine & Nutrigenomics Laboratory , Department of Bio-Medical Laboratory Science and Management, Vidyasagar University , Midnapore , West Bengal , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinandan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Molecular Medicine & Nutrigenomics Laboratory , Department of Bio-Medical Laboratory Science and Management, Vidyasagar University , Midnapore , West Bengal , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhabani Prasad","family":"Pakhira","sequence":"additional","affiliation":[{"name":"Molecular Medicine & Nutrigenomics Laboratory , Department of Bio-Medical Laboratory Science and Management, Vidyasagar University , Midnapore , West Bengal , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debidas","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Nutrigenomics Research Laboratory , Department of Bio-Medical Laboratory Science & Management,Vidyasagar University , Midnapore , West Bengal , India - 721 102"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"2025121209203387893_j_jcim-2016-0084_ref_001_w2aab3b7b3b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Ballester J, Munoz MC, Dominguez J, Rigau T, Guinovart JJ, Rodriguez-Gil JE. 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