{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:56:27Z","timestamp":1781682987004,"version":"3.54.5"},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2016-0130_s_011_w2aab2b8c30b1b7b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Anogeissus latifolia<\/jats:italic>\n                      Wall. (\n                      <jats:italic>A. latifolia<\/jats:italic>\n                      ) bark has been traditionally used in the treatment of various diseases which includes diabetes and general debility. The present study was aimed to investigate the comparative hypoglycemic and hypolipidemic activity of various extracts of\n                      <jats:italic>A. latifolia<\/jats:italic>\n                      bark in streptozotocin-induced type 1 diabetic rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0130_s_012_w2aab2b8c30b1b7b1aab1c14b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Acute toxicity was carried out at 2\u2006g\/kg dose of petroleum ether extract of\n                      <jats:italic>A. latifolia<\/jats:italic>\n                      bark (PEALB), chloroform extract of\n                      <jats:italic>A. latifolia<\/jats:italic>\n                      bark (CEALB) and methanol extract of\n                      <jats:italic>A. latifolia<\/jats:italic>\n                      bark (MEALB) in rats. Diabetes was induced by streptozotocin (STZ, 60\u2006mg\/kg, i.p.) and it was confirmed at 72 h. Diabetic rats received above extracts at 100 and 200\u2006mg\/kg doses for 28 days. Body weight and blood glucose level were determined at every week after the treatment schedule. Serum biochemical parameters and lipid profile levels were estimated at the end of the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0130_s_013_w2aab2b8c30b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PEALB, CEALB and MEALB were non-toxic and no death was observed at 2\u2006g\/kg dose. Administration of MEALB at 100 and 200\u2006mg\/kg showed significant (p&lt; 0.01, p&lt; 0.05) improvement in body weight and reduction in blood glucose at third and fourth week of treatment. Altered serum biochemical parameters and lipid profiles level were brought to near normal level significantly (p&lt;0.001) compared to diabetic control rats after the administration of both doses of MEALB. However, PEALB and CEALB did not exhibit significant hypoglycemic and hypolipidemic activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0130_s_014_w2aab2b8c30b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings revealed that long-term (28 days) treatment of MEALB possesses significant hypoglycemic and hypolipidemic activity compared to PEALB and CEALB in type 1 diabetic rats and given evidence to the traditional use of\n                      <jats:italic>A. latifolia<\/jats:italic>\n                      bark in diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2016-0130","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T06:09:38Z","timestamp":1493964578000},"source":"Crossref","is-referenced-by-count":9,"title":["Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of\n                    <i>Anogeissus latifolia<\/i>\n                    bark in streptozotocin-induced diabetic rats"],"prefix":"10.1515","volume":"14","author":[{"given":"Subramaniam","family":"Ramachandran","sequence":"first","affiliation":[{"name":"KMCH College of Pharmacy , Kovai Estate , Kalapatti Road-641 048, , Coimbatore Tamil Nadu , India"},{"name":"KMCH College of Pharmacy , Kovai Estate , Kalapatti Road-641 048, , Coimbatore Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thekkin Kattil","family":"Faisal","sequence":"additional","affiliation":[{"name":"KMCH College of Pharmacy , Kovai Estate , Kalapatti Road-641 048, , Coimbatore Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Anjumary","sequence":"additional","affiliation":[{"name":"Pharmacopoeia Commission for Indian Medicine and Homoeopathy (PCIM&H) , PLIM Campus, Kamla Nehru Nagar , Post Kavi Nagar , Ghaziabad Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyalu","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"College of Pharmacy , Sri Ramakrishna Institute of Paramedical Sciences , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuppusamy","family":"Asokkumar","sequence":"additional","affiliation":[{"name":"Independent Researcher , 1805 Cholla Ct, Apt #C , Indianapolis , IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuppusamy","family":"Annadurai","sequence":"additional","affiliation":[{"name":"KMCH College of Pharmacy , Kovai Estate , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy","family":"Arivukkarasu","sequence":"additional","affiliation":[{"name":"Pharmacopoeia Commission for Indian Medicine and Homoeopathy (PCIM&H) , PLIM Campus , Kamla Nehru Nagar, Post Kavi Nagar , Ghaziabad , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Pharmacopoeia Commission for Indian Medicine and Homoeopathy (PCIM&H) , PLIM Campus , Kamla Nehru Nagar, Post Kavi Nagar , Ghaziabad , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhira Bhavani","family":"Shankar","sequence":"additional","affiliation":[{"name":"Pharmacopoeia Commission for Indian Medicine and Homoeopathy (PCIM&H) , PLIM Campus , Kamla Nehru Nagar, Post Kavi Nagar , Ghaziabad , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"2025121209181002376_j_jcim-2016-0130_ref_001_w2aab2b8c30b1b7b1ab2b1b1Aa","unstructured":"Kumar V, Abbas K, Fausto N. 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