{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:33:25Z","timestamp":1765542805014,"version":"3.48.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2016-0132_s_006_w2aab3b7b6b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d1690857e19730_w2aab3b7b6b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>Quinine (QT) is an important anti-malarial drug; however, there is little information about its effects on the gut. Therefore, this study aimed to investigate the effects of a therapeutic dose of QT on the healing of gastric ulcer in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0132_s_007_w2aab3b7b6b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d1690857e19739_w2aab3b7b6b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>Male Wistar rats weighing 150\u2013200\u2006g were divided into three groups: control rats without ulcer (group 1), ulcerated rats treated with 1 mL\/kg (p.o.) normal saline (NS) (group 2), and ulcerated rats treated with 10\u2009mg\/kg (p.o.) QT (group 3). Ulcers were induced by serosal application of 80\u2006% acetic acid to the stomach of rats anaesthetized with 50\u2009mg\/kg thiopentone sodium and treatment was given three times daily. Healing was assessed on days 3, 7 and 10 after ulcer induction by macroscopic measurement of: ulcer area, histology, lipid peroxidation, superoxide dismutase activity and gastric mucus secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0132_s_008_w2aab3b7b6b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d1690857e19748_w2aab3b7b6b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>At day 3, there was no significant difference (p&gt;0.05) in ulcer areas between NS- and QT-treated rats. By day 10, however, the percentage area healed in NS treated (59.6\u00b12.35\u2006%) was significantly higher (p&lt;0.05) than in QT rats (49.0\u00b12.20\u2006%) and clearing of inflammatory cells and re-epithelization was greater in NS-treated group. By days 7 and 10, lipid peroxidation was significantly higher in QT animals, when compared with NS-treated rats and controls (p&lt;0.05). Superoxide dismutase activity and mucus secretion were significantly (p&lt;0.05) higher in NS-treated than QT-treated rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2016-0132_s_009_w2aab3b7b6b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d1690857e19757_w2aab3b7b6b1b6b1aab1c16b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>QT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2016-0132","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T03:54:20Z","timestamp":1499054060000},"source":"Crossref","is-referenced-by-count":2,"title":["Effects of quinine on gastric ulcer healing in Wistar rats"],"prefix":"10.1515","volume":"14","author":[{"given":"Olasupo Stephen","family":"Adeniyi","sequence":"first","affiliation":[{"name":"Kogi State University , Department of Physiology, College of Health Sciences , P.M.B. 1008, Kogi State , Anyigba , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olubiyi Vincent","family":"Makinde","sequence":"additional","affiliation":[{"name":"Department of Physiology , College of Health Sciences, Kogi State University , Anyigba , Kogi State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel Titus","family":"Friday","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , College of Health Sciences, Kogi State University , Anyigba , Kogi State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Babafemi","family":"Olaleye","sequence":"additional","affiliation":[{"name":"Department of Physiology , College of Medicine, University of Ibadan , Ibadan , Oyo State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"2025121209265151425_j_jcim-2016-0132_ref_001_w2aab3b7b6b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Khoder G, Al-Manhali AA, Al-Yassir F, Karam SM. 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