{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:24:56Z","timestamp":1765542296100,"version":"3.48.0"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2017-0012_s_021_w2aab3b7b4b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d5610542e16650_w2aab3b7b4b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Ardisia crispa<\/jats:italic>\n                      Thunb A.DC (Myrsinaceae), commonly known as \u201chen\u2019s eyes\u201d, has been traditionally used in treating various inflammatory diseases. The present study evaluated anti-arthritic, gastroprotective and antioxidant activities of\n                      <jats:italic>Ardisia crispa<\/jats:italic>\n                      root hexane extract (ACRH) in various animal models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0012_s_022_w2aab3b7b4b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d5610542e16664_w2aab3b7b4b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>Anti-arthritic activity was evaluated in complete Freund adjuvant (CFA)-induced adjuvant arthritis and gastroprotective effect was studied in the ethanol-induced ulcer model in rats. ACRH was further isolated to yield quinone-rich fraction (QRF) and both were analyzed for their total phenolic content, total flavonoid content and antioxidant activities in various antioxidant assays. Both ACRH and QRF were also analyzed for the quinone composition via gas chromatography analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0012_s_023_w2aab3b7b4b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d5610542e16673_w2aab3b7b4b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>ACRH exerted significant reduction of IL-1\u03b2 and TNF-\u03b1 at a lower dose range in CFA-induced arthritis, as well as exhibited its cytoprotective effect against ethanol-induced ulcer lesion via involvement of mucosal nonprotein sulfhydryl (NP-SH) groups. ACRH also showed higher phenolic and flavonoid contents, as well as better antioxidant activities than QRF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0012_s_024_w2aab3b7b4b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d5610542e16682_w2aab3b7b4b1b6b1aab1c16b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrated the plant as a potential anti-inflammatory agent, with ACRH succeeded in inhibiting both arthritic and ulcerogenic effect, possibly mediated via its antioxidant effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2017-0012","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T06:01:57Z","timestamp":1505455317000},"source":"Crossref","is-referenced-by-count":7,"title":["Anti-arthritic and gastroprotective activities of\n                    <i>Ardisia crispa<\/i>\n                    root partially mediated via its antioxidant effect"],"prefix":"10.1515","volume":"15","author":[{"given":"Roslida Abdul","family":"Hamid","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Selangor , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lau Moi","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Selangor , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Looi","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Selangor , Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"2025121209221483255_j_jcim-2017-0012_ref_001_w2aab3b7b4b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Zhou J, Xie G, Yan X. 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