{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:38:44Z","timestamp":1768869524348,"version":"3.49.0"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2017-0086_s_007_w2aab3b7c11b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d5610542e67041_w2aab3b7c11b1b6b1aab1c17b1aAa\">Background<\/jats:title>\n                    <jats:p>Cisplatin-induced acute liver and kidney injuries are serious problems in cancer patients during treatment of solid tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0086_s_008_w2aab3b7c11b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d5610542e67050_w2aab3b7c11b1b6b1aab1c17b2aAa\">Objective<\/jats:title>\n                    <jats:p>\n                      This study sought to investigate possible protective effect of ethanolic fruit extract of\n                      <jats:italic>Citrullus colocynthis<\/jats:italic>\n                      (CC) against cisplatin-induced hepato-renal toxicity in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0086_s_009_w2aab3b7c11b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d5610542e67062_w2aab3b7c11b1b6b1aab1c17b3aAa\">Methods<\/jats:title>\n                    <jats:p>Thirty male albino rats (150\u2013200 g) were divided into five groups (n=6) and treated as follows: group 1: vehicle (10 mL\/kg, p.o.; normal control); group 2: vehicle (10 mL\/kg); groups 3\u20135: CC (100, 200 or 400 mg\/kg, p.o.), respectively, for 10 days. Cisplatin (7.5 mg\/kg; i.p.) was administered on the 7th day to animals in groups (2\u20135) 1 h after pretreatment. The animals were euthanized on day 10 for haematological, biochemical and histological analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0086_s_010_w2aab3b7c11b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d5610542e67071_w2aab3b7c11b1b6b1aab1c17b4aAa\">Results<\/jats:title>\n                    <jats:p>\n                      Cisplatin induced a significant increase in the serum levels of ALT, ALP, creatinine and blood urea nitrogen indicative of hepato-renal injury. More so, cisplatin caused marked increase in granulocyte, lymphocyte and platelets counts which were ameliorated by CC (100\u2013400 mg\/kg) treatment. In addition, cisplatin induced marked increase in MDA and nitrite levels coupled with deficits in glutathione, catalase and superoxide dismutase activities which were attenuated by CC administration.\n                      <jats:italic>In vitro<\/jats:italic>\n                      assay showed that CC scavenged DPPH and nitrite radicals (69.50 and 64.50 \u00b5g\/mL, respectively). Total antioxidant capacity, phenolic and flavonoid contents are 24.27\u00b10.09 mg QUE\/g, 17.14\u00b10.12 mg GAE\/g and 10.20\u00b10.09 mg QUE\/g, respectively. CC preserved the liver and kidney histoarchitecture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0086_s_011_w2aab3b7c11b1b6b1aab1c17b5Aa\">\n                    <jats:title id=\"d5610542e67083_w2aab3b7c11b1b6b1aab1c17b5aAa\">Conclusions<\/jats:title>\n                    <jats:p>\n                      This study showed that\n                      <jats:italic>C. colocynthis<\/jats:italic>\n                      possesses hepatoprotective and nephroprotective actions possibly through enhancement of antioxidant defence system. Thus, it could be a potential adjuvant in cisplatin-based chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2017-0086","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T02:59:31Z","timestamp":1513133971000},"source":"Crossref","is-referenced-by-count":15,"title":["<i>Citrullus colocynthis<\/i>\n                    Linn. 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