{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:07:30Z","timestamp":1768082850255,"version":"3.49.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2017-0164_s_005_w2aab3b7c13b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d684260e55434_w2aab3b7c13b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>Favism is an acute hemolytic anemia occurs in glucose 6-phosphate dehydrogenase (G6-PD) deficient individuals. \u03b2-Carotene occurs in vegetables such as carrots. This study aimed to establish the therapeutic effect of \u03b2-carotene to rebalance the testicular and blood proteins disturbances in favism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0164_s_006_w2aab3b7c13b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d684260e55443_w2aab3b7c13b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>\n                      Forty-eight male rats were divided into six equal groups; Groups 1, 2 and 3: normal rats were daily oral administrated with 1 ml saline, 1 ml corn oil and \u03b2-carotene (60 mg\/kg dissolved in 1 ml corn oil), respectively, once a day over 15 days period. Group 4 (favism-induced group): normal rats injected intraperitoneal (ip) with diethyl maleate (5 \u03bcl\/rat) and after 1 h injected ip with 1\/3 LD\n                      <jats:sub>50<\/jats:sub>\n                      of faba beans ethanolic extract for 15 day to induce favism. Groups 5 and 6: favism-induced rats were daily oral administered with 30 and 60 mg\/kg \u03b2-carotene dissolved in 1 ml corn oil, respectively, once a day over 15 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0164_s_007_w2aab3b7c13b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d684260e55455_w2aab3b7c13b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>The results revealed that oral administration of corn oil or \u03b2-carotene into normal rats over 15 days period did not induce any change. In favism-induced groups, hematological parameters, liver function, serum glucose, G6-PD, luteinizing and follicle-stimulating hormones and sex-hormone binding globulin showed significant increase. Moreover, serum testosterone and dehydroepiandrosterone sulfate, testicular G6-PD, 3\u03b2-hydroxy steroid dehydrogenase, cholesterol and total protein were decreased. Treatment with both doses of \u03b2-carotene into favism groups restored all the abovementioned parameters to approach normal values. Favism inhibited blood proteins while \u03b2-carotene treatment into favism group stopped blood cells damage and blood proteins inhibition. These results were supported by histological studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2017-0164_s_008_w2aab3b7c13b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d684260e55464_w2aab3b7c13b1b6b1aab1c16b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>In conclusion, taken \u03b2-carotene into favism group abolished testicular and blood proteins disturbances and this effect was dose dependent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2017-0164","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T04:50:24Z","timestamp":1523508624000},"source":"Crossref","is-referenced-by-count":8,"title":["Evaluating of \u03b2-carotene role in ameliorating of favism-induced disturbances in blood and testis"],"prefix":"10.1515","volume":"15","author":[{"given":"Khaled M. 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