{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:30:53Z","timestamp":1765542653794,"version":"3.48.0"},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2018-0073_s_001a_w2aab3b7c31b1b6b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hypertension is a silent killer with no obvious signs and symptoms; thus, it is crucial to prevent its development. Oxidative stress and hyperlipidemia are associated risk factors for developing hypertension. This study aimed at investigating the role of a crude extract of\u00a0\n                      <jats:italic>Senecio serratuloides<\/jats:italic>\n                      in preventing the development of hypertension, oxidative stress and hyperlipidemia in a rat model of nitric oxide deficiency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0073_s_001b_w2aab3b7c31b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Female Wistar rats were co-treated with N\u03c9-Nitro L-arginine methyl ester (L-NAME) (40\u2009mg\/kg) and the hydroethanolic extract of\n                      <jats:italic>S. Serratuloides<\/jats:italic>\n                      (HESS150 or HESS300\u2009mg\/kg) for 4\u2009weeks. Twenty-hour urine samples were collected weekly during the study. At the end of the study serum, heart and kidneys were harvested for biochemical and histopathological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0073_s_001c_w2aab3b7c31b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The higher dose (300\u2009mg\/kg) of the extract was more effective\u00a0in preventing increase in systolic (p&lt;0.001) and diastolic (p&lt;0.05) blood pressure. At the end of the treatment period HESS300 treated rats had significantly (p&lt;0.01) higher concentration of creatinine (91.24\u2009\u00b1\u20096\u2009mg\/dL) in urine and significantly (6.36\u2009\u00b1\u20090.4\u2009mg\/24\u2009h; 0.001) lower proteinuria compared to L-NAME control rats (55.75\u2009\u00b1\u20098\u2009mg\/dL and 18.92\u2009\u00b1\u20092\u2009mg\/24\u2009h, respectively). Creatinine clearance and glomerular filtration rate were lower in the L-NAME control group compared to all treatment groups. HESS300 prevented L-NAME-induced decrease in serum angiotensin II concentration, significantly decreased malondialdehyde concentration in serum (p&lt;0.05) and kidneys (p&lt;0.001). It also significantly (p&lt;0.001) decreased low-density lipoprotein concentration while increasing the concentration of high-density lipoprotein cholesterol. It showed cardio- and reno-protective effects and significantly (p&lt;0.01) prevented collagen deposition in these target organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0073_s_001d_w2aab3b7c31b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate the potential of\n                      <jats:italic>S. Serratuloides<\/jats:italic>\n                      in protecting rats from developing hypertension, hyperlipidemia and oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2018-0073","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T04:02:08Z","timestamp":1581393728000},"source":"Crossref","is-referenced-by-count":3,"title":["<i>Senecio serratuloides<\/i>\n                    extract prevents the development of hypertension, oxidative stress and dyslipidemia in nitric oxide-deficient rats"],"prefix":"10.1515","volume":"17","author":[{"given":"Charlotte Mungho","family":"Tata","sequence":"first","affiliation":[{"name":"Department of Human Biology, Faculty of Health Sciences , Walter Sisulu University , p\/bag x1,NMD Campus , Mthatha 5117 , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance Rufaro","family":"Sewani-Rusike","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Health Sciences , Walter Sisulu University , p\/bag x1,NMD Campus , Mthatha 5117 , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Opeopluwa Oyehan","family":"Oyedeji","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Agriculture , University of Fort Hare , Alice , 5700 , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikile","family":"Mahlakata","sequence":"additional","affiliation":[{"name":"Traditional Healer , Lusikisiki , Eastern Cape , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathulo","family":"Shauli","sequence":"additional","affiliation":[{"name":"Department of Human Biology, Faculty of Health Sciences , Walter Sisulu University , p\/bag x1,NMD Campus , Mthatha 5117 , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicta Ngwenchi","family":"Nkeh-Chungag","sequence":"additional","affiliation":[{"name":"Department of Physiology , Walter Sisulu University , Mthatha 5117 , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,2,8]]},"reference":[{"key":"2025121209234458409_j_jcim-2018-0073_ref_001_w2aab3b7c31b1b6b1ab2b1b1Aa","unstructured":"American Heart Association. 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