{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:38:39Z","timestamp":1784126319801,"version":"3.55.0"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2018-0128_s_001a_w2aab3b8c43b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This randomized controlled pilot study evaluated the efficacy of osteopathic treatment in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) assessed using spirometry, COPD Assessment Test (CAT) and six minutes walking test (6MWT). The main goals were to improve the quality of life of patients with stable moderate-to-severe COPD, and to revise the parameters of the assessment tests, such as spirometry and 6MWT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0128_s_002a_w2aab3b8c43b1b7b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study comprised several phases and patients were divided into two groups: group A (controls) received conventional pharmacological treatment with Indacaterol\u2013Glycopyrronium and, while group B (OMT group) received both traditional therapy and osteopathic manipulative treatment (OMT) at different stages of the study. The osteopathic approach focused on maxillary sinus, vertebral-pleural ligaments, phrenic nerves, ribs, pleura, lungs, bronchi, subclavian muscles, and trapezoid and conoid ligaments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0128_s_003a_w2aab3b8c43b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 32 patients were randomized and treated. Patients of the OMT group got better improvements in all tests compared to the control group: spirometry: FVC (p&lt;0.5411), total FEV1 (p&lt;0.5061); CAT: OMT (p&lt;0.0005) - controls (p&lt;0.188) 6MWT OMT (p&lt;0.0038) - controls (p&lt;0.5326). The clinical results collected in phase (T3) confirm those obtained in the first sessions; the results of CAT questionnaire (p&lt;0.0005) and 6MWT (p&lt;O, OO38) highlighted score improvements of patients treated with osteopathy compared to patients in the other group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0128_s_004a_w2aab3b8c43b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results showed that the patients with COPD who received the conventional pharmacological treatment in association with the OMT therapy demonstrated a good response to the osteopathic treatment, thus leading to significant improvements in their health and wellbeing, and a better daily functioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2018-0128","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T05:07:19Z","timestamp":1566536839000},"source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of osteopathic treatment in patients with stable moderate-to-severe chronic obstructive pulmonary disease: a randomized controlled pilot study"],"prefix":"10.1515","volume":"17","author":[{"given":"Andrea","family":"Buscemi","sequence":"first","affiliation":[{"name":"Study Center of Italian Osteopathy , Catania , Italy"},{"name":"Horus Social Cooperative , Ragusa , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Pennisi","sequence":"additional","affiliation":[{"name":"Study Center of Italian Osteopathy , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rapisarda","sequence":"additional","affiliation":[{"name":"Study Center of Italian Osteopathy , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfio","family":"Pennisi","sequence":"additional","affiliation":[{"name":"Calaciura Rehabilitation Center , Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Coco","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences and Research Center on Motor Activities (CRAM) , University of Catnia , 95124 Catania CT , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"2025121209302534211_j_jcim-2018-0128_ref_001_w2aab3b8c43b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Viegi G, Pistelli F, Sherril DF. Definition, epidemiology and natural history of COPD. EurRespir J 2007;30:993\u20131013.","DOI":"10.1183\/09031936.00082507"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_002_w2aab3b8c43b1b7b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Monninkhof E, van der Valk P, van der Palen J, van Herwaarden C, Partridge MR, Zielhuis G. Self-management education for patients with chronic obstructive pulmonary disease: a systematic review. Thorax 2003;58:394\u20138.","DOI":"10.1136\/thorax.58.5.394"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_003_w2aab3b8c43b1b7b1ab2b2b3Aa","unstructured":"Silva RO. Clinical phenotypes in chronic obstructive pulmonary disease. RevMed Chile 2012;140:926\u201333."},{"key":"2025121209302534211_j_jcim-2018-0128_ref_004_w2aab3b8c43b1b7b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Effing T, Monninkhof EM, van der Valk PD, van der Palen J, van Herwaarden CL, Partidge MR, et al. Self-management education for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2007;4:CD002990.","DOI":"10.1002\/14651858.CD002990.pub2"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_005_w2aab3b8c43b1b7b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Maltais F, Bourbeau J, Shapiro S, Lacasse Y, Perrault H, Baltzan M, et al. Chronic obstructive pulmonary disease axis of respiratory health network, fonds de recherche en sant\u00e9 du Qu\u00e9bec. Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 2008;149:869\u201378.","DOI":"10.7326\/0003-4819-149-12-200812160-00006"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_006_w2aab3b8c43b1b7b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Steel A, Sundberg T, Reid R, Ward L, Bishop FL, Leach M, et al. Osteopathic manipulative treatment: a systematic review and critical appraisal of comparative effectiveness and health economics reserch. Musculoskelet Sci Pract 2017;27:165\u201375.","DOI":"10.1016\/j.math.2016.10.067"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_007_w2aab3b8c43b1b7b1ab2b2b7Aa","unstructured":"Anthony GC. Fondamenti di medicina osteopatica, 2 edizione italiana ed. Osteopathic rationale: Casa Editrice Ambrosiana, 2015."},{"key":"2025121209302534211_j_jcim-2018-0128_ref_008_w2aab3b8c43b1b7b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of ATS\/ERS position paper. Eur Respir J 2004;23:932\u201346.","DOI":"10.1183\/09031936.04.00014304"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_009_w2aab3b8c43b1b7b1ab2b2b9Aa","doi-asserted-by":"crossref","unstructured":"Lacasse Y, Goldstein R, Lasserson TJ, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006;18:CD003793.","DOI":"10.1002\/14651858.CD003793.pub2"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_010_w2aab3b8c43b1b7b1ab2b2c10Aa","doi-asserted-by":"crossref","unstructured":"Clini EM, Crisafulli E, Costi S, Rossi G, Lorenzi C, Fabbri LM, et al. Effects of early inpatient rehabilitation after acute exacerbation of COPD. Respir Med 2009;103:1526\u201331.","DOI":"10.1016\/j.rmed.2009.04.011"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_011_w2aab3b8c43b1b7b1ab2b2c11Aa","doi-asserted-by":"crossref","unstructured":"Carone M, Patessio A, Ambrosino N, Baiardi P, Balbi B, Balzano G, et al. Effect of pulmonary rehabilitation in chronic respiratory failure (CRF) due to chronic obstructive pulmonary disease (COPD): the Maugeri study. Respir Med 2007;101:2447\u201353.","DOI":"10.1016\/j.rmed.2007.07.016"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_012_w2aab3b8c43b1b7b1ab2b2c12Aa","doi-asserted-by":"crossref","unstructured":"Puhan M, Scharplatz M, Troosters T, Walters EH, Steurer J. Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2009;21:CD005305.","DOI":"10.1002\/14651858.CD005305.pub2"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_013_w2aab3b8c43b1b7b1ab2b2c13Aa","doi-asserted-by":"crossref","unstructured":"Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Ant\u00f3 JM. Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease. A population-based cohort study. Am J RespirCrit Care Med 2007;175:458\u201363.","DOI":"10.1164\/rccm.200607-896OC"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_014_w2aab3b8c43b1b7b1ab2b2c14Aa","doi-asserted-by":"crossref","unstructured":"ATS Statement. Guidelines for the six minute walk test. Am J RespirCrit Care Med 2002;116:111\u20137.","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2025121209302534211_j_jcim-2018-0128_ref_015_w2aab3b8c43b1b7b1ab2b2c15Aa","doi-asserted-by":"crossref","unstructured":"Heneghan NR, Adab P, Balanos GM, Jordan RE. Manual therapy for chronic obstructive airways disease: a systematic review of current evidence. Man Ther 2012;17:507\u201318.","DOI":"10.1016\/j.math.2012.05.004"}],"container-title":["Journal of Complementary and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jcim\/17\/1\/article-20180128.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2018-0128\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2018-0128\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:32:43Z","timestamp":1765542763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2018-0128\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,23]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,8,15]]},"published-print":{"date-parts":[[2020,2,25]]}},"alternative-id":["10.1515\/jcim-2018-0128"],"URL":"https:\/\/doi.org\/10.1515\/jcim-2018-0128","relation":{},"ISSN":["1553-3840"],"issn-type":[{"value":"1553-3840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,23]]},"article-number":"20180128"}}