{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:35:30Z","timestamp":1774658130207,"version":"3.50.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2018-0207_s_005_w2aab3b7c14b1b6b1aab1c16b1Aa\">\n                    <jats:title id=\"d1985615e49732_w2aab3b7c14b1b6b1aab1c16b1aAa\">Background<\/jats:title>\n                    <jats:p>\n                      Seaweeds are a famous traditional food resource in some countries containing different types of secondary metabolites. These marine organisms have shown different biological activities. The aim of this study was to investigate the effects of hexane and methanol extracts of\n                      <jats:italic>Sargassum plagyophylum<\/jats:italic>\n                      on depression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0207_s_006_w2aab3b7c14b1b6b1aab1c16b2Aa\">\n                    <jats:title id=\"d1985615e49744_w2aab3b7c14b1b6b1aab1c16b2aAa\">Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Sargassum plagyophylum<\/jats:italic>\n                      was collected from Persian Gulf. The plant was extracted by maceration with methanol-ethyl acetate solvent. The extract was evaporated and partitioned by hexane and methanol solvents. The two partitions were administered i.p. to male mice either a single dose or for 7\u2006days. Depression was evaluated by the forced swimming test (FST) which higher immobility time indicates depressive-like behavior.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0207_s_007_w2aab3b7c14b1b6b1aab1c16b3Aa\">\n                    <jats:title id=\"d1985615e49755_w2aab3b7c14b1b6b1aab1c16b3aAa\">Results<\/jats:title>\n                    <jats:p>\n                      The immobility time during FST decreased significantly by all the doses of the hexane partitions (notably 40\u2009mg\/kg; 10\u2006s\u00a0\u00b1\u20092 vs. 114\u2006s\u00a0\u00b1\u200912 control group). However, only the lowest dose (20\u2009mg\/kg) of the methanol partition reduced immobility time during FST (23\u2006s\u00a0\u00b1\u20098,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.001). Following the long term administration both of the partitions reduced the immobility time in FST (hexane 27\u2006s\u00a0\u00b1\u200911, methanol 70\u2006s\u00a0\u00b1\u200914,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.05 vs. control 140\u2006s\u00a0\u00b1\u200914).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2018-0207_s_008_w2aab3b7c14b1b6b1aab1c16b4Aa\">\n                    <jats:title id=\"d1985615e49770_w2aab3b7c14b1b6b1aab1c16b4aAa\">Conclusion<\/jats:title>\n                    <jats:p>\n                      The hexane partition showed antidepressant effects not only by long-term administration but also by the single dose during FST. The 7\u2006days therapy with methanol partition also induced antidepressant behavior, but only the lowest single dose reduced immobility in FST. The methanol partitions possibly have certain substance that interfered with behavior in the FST. Therefore,\n                      <jats:italic>S. plagyophylum<\/jats:italic>\n                      should be considered for further antidepressant studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2018-0207","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T05:02:35Z","timestamp":1558674155000},"source":"Crossref","is-referenced-by-count":11,"title":["The effect of different partitions of seaweed\n                    <i>Sargassum plagyophylum<\/i>\n                    on depression behavior in mice model of despair"],"prefix":"10.1515","volume":"16","author":[{"given":"Azadeh","family":"Mesripour","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences , Isfahan University of Medical Sciences , Isfahan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Rabian","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences , Isfahan University of Medical Sciences , Isfahan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsaneh","family":"Yegdaneh","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences , Isfahan University of Medical Sciences , Isfahan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"2025121209252836130_j_jcim-2018-0207_ref_001_w2aab3b7c14b1b6b1ab1b5b1Aa","unstructured":"Ashwani A, Preeti V. A review on pathophysiology, classification and long term course of depression. Int Res J Pharm 2012;3:90\u20136."},{"key":"2025121209252836130_j_jcim-2018-0207_ref_002_w2aab3b7c14b1b6b1ab1b5b2Aa","unstructured":"Kothar S, Minda M, Tonpay S. Anxiolytic and antidepressant activities of methanol extract of Aegle marmelos leaves in mice. Indian J Physiol Pharmacol 2010;54:318\u201328.21675029"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_003_w2aab3b7c14b1b6b1ab1b5b3Aa","unstructured":"Safaeian L, Hajhashemi V, Haghjoo Javanmard S, Sanaye Naderia H. The effect of protocatechuic acid on blood pressure and oxidative stress in glucocorticoid-induced hypertension in rat. Iran J Pharm Res 2016;15:83\u201391.28228807"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_004_w2aab3b7c14b1b6b1ab1b5b4Aa","unstructured":"Ghannadi A, Plubrukarn A, Zandi K, Sartavi K, Yegdaneh A. Screening for antimalarial and acetylcholinesterase inhibitory activities of some Iranian seaweeds. Res Pharm Sci 2013;8:113\u20136.24019820"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_005_w2aab3b7c14b1b6b1ab1b5b5Aa","doi-asserted-by":"crossref","unstructured":"Schwartsmann G, Brondani Da Rocha A, Berlinck RG, Jimeno J. Marine organisms as a source of new anticancer agents. Lancet Oncol 2001;2:221\u20135.1190576710.1016\/S1470-2045(00)00292-8","DOI":"10.1016\/S1470-2045(00)00292-8"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_006_w2aab3b7c14b1b6b1ab1b5b6Aa","doi-asserted-by":"crossref","unstructured":"Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT, Prinsep MR Marine natural products. Nat Prod Rep 2009;26:170\u2013244.1917722210.1039\/b805113p","DOI":"10.1039\/b805113p"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_007_w2aab3b7c14b1b6b1ab1b5b7Aa","doi-asserted-by":"crossref","unstructured":"Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981\u22122002. J Nat Prod 2003;66:1022\u201337.10.1021\/np030096l12880330","DOI":"10.1021\/np030096l"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_008_w2aab3b7c14b1b6b1ab1b5b8Aa","doi-asserted-by":"crossref","unstructured":"Yegdaneh A, Putchakarn S, Yuenyongsawad S, Ghannadi A, Plubrukarn A. 3-oxoabolene and 1-oxocurcuphenol, aromatic bisabolanes from the sponge Myrmekioderma sp. Nat Prod Commun. 2013;8:1355\u20137.24354172","DOI":"10.1177\/1934578X1300801002"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_009_w2aab3b7c14b1b6b1ab1b5b9Aa","doi-asserted-by":"crossref","unstructured":"Solanki R, Khanna M, Lal R. Bioactive compounds from marine actinomycetes. Indian J Microbiol 2008;48:410\u201331.10.1007\/s12088-008-0052-z23100742","DOI":"10.1007\/s12088-008-0052-z"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_010_w2aab3b7c14b1b6b1ab1b5c10Aa","doi-asserted-by":"crossref","unstructured":"Rinehart KL. Antitumor compounds from tunicates. Med Res Rev 2000;20:1\u201327.10.1002\/(SICI)1098-1128(200001)20:1<1::AID-MED1>3.0.CO;2-A10608919","DOI":"10.1002\/(SICI)1098-1128(200001)20:1<1::AID-MED1>3.0.CO;2-A"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_011_w2aab3b7c14b1b6b1ab1b5c11Aa","doi-asserted-by":"crossref","unstructured":"Yegdaneh A, Ghannadi A, Dayani L. Chemical constituents and biological activities of two Iranian Cystoseira species. Res Pharm Sci. 2016;11:311.2765181110.4103\/1735-5362.189307","DOI":"10.4103\/1735-5362.189307"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_012_w2aab3b7c14b1b6b1ab1b5c12Aa","doi-asserted-by":"crossref","unstructured":"Tang HF, Yang-Hua Y, Yao XS, Xu QZ, Zhang SY, Lin HW. Bioactive steroids from the brown alga Sargassum carpophyllum. J Asian Nat Prod Res. 2002;4:95\u2013101.1206716510.1080\/10286020290027362","DOI":"10.1080\/10286020290027362"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_013_w2aab3b7c14b1b6b1ab1b5c13Aa","unstructured":"Mehdinezhad N, Ghannadi A, Yegdaneh A. Phytochemical and biological evaluation of some Sargassum species from Persian Gulf. Res Pharm Sci. 2016;11:243.27499794"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_014_w2aab3b7c14b1b6b1ab1b5c14Aa","doi-asserted-by":"crossref","unstructured":"Ghannadi A, Shabani L, Yegdaneh A. Cytotoxic, antioxidant and phytochemical analysis of Gracilaria species from Persian Gulf. Adv Biomed Res. 2016;5:112\u20134.","DOI":"10.4103\/2277-9175.187373"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_015_w2aab3b7c14b1b6b1ab1b5c15Aa","doi-asserted-by":"crossref","unstructured":"Zhen XH, Quan YC, Jiang HY, Wen ZS, Qu YL, Guan LP. Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects. Eur J Pharmacol. 2015;768:131\u20138.10.1016\/j.ejphar.2015.10.04126515446","DOI":"10.1016\/j.ejphar.2015.10.041"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_016_w2aab3b7c14b1b6b1ab1b5c16Aa","unstructured":"Sohrabipour J, Rabiei R. The checklist of green algae of the Iranian coastal lines of the Persian Gulf and Gulf of Oman. Iran J Bot 2007;13:146\u20139."},{"key":"2025121209252836130_j_jcim-2018-0207_ref_017_w2aab3b7c14b1b6b1ab1b5c17Aa","doi-asserted-by":"crossref","unstructured":"Kupchan SM, Tsou G. Tumor inhibitors. LXXXI. Structure and partial synthesis of fabacein. J Org Chem 1973;38:1055\u20136.10.1021\/jo00945a044","DOI":"10.1021\/jo00945a044"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_018_w2aab3b7c14b1b6b1ab1b5c18Aa","unstructured":"Fashi YA, Mesripour A, Hajhashemi V. Evaluation of the effect of soybean diet on interferon-\u03b1-induced depression in male mice. Avicenna J Phytomed 2017;7:436.29062805"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_019_w2aab3b7c14b1b6b1ab1b5c19Aa","doi-asserted-by":"crossref","unstructured":"Cryan JF, Valentino RJ, Lucki. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 2005;29:547\u201369.1589382210.1016\/j.neubiorev.2005.03.008","DOI":"10.1016\/j.neubiorev.2005.03.008"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_020_w2aab3b7c14b1b6b1ab1b5c20Aa","doi-asserted-by":"crossref","unstructured":"Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000;157:1552\u201362.1100770510.1176\/appi.ajp.157.10.1552","DOI":"10.1176\/appi.ajp.157.10.1552"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_021_w2aab3b7c14b1b6b1ab1b5c21Aa","doi-asserted-by":"crossref","unstructured":"Lino-de-Oliveira C, De Lima TC, de P\u00e1dua Carobrez A. Structure of the rat behaviour in the forced swimming test. Behav Brain Res 2005;158:243\u201350.10.1016\/j.bbr.2004.09.00415698890","DOI":"10.1016\/j.bbr.2004.09.004"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_022_w2aab3b7c14b1b6b1ab1b5c22Aa","doi-asserted-by":"crossref","unstructured":"Ina A, Hayashi K, Nozaki H, Kamei Y. Pheophytin a, a low molecular weight compound found in the marine brown alga Sargassum fulvellum, promotes the differentiation of PC12 cells. Int J Dev Neurosci. 2007;25:63\u20138.10.1016\/j.ijdevneu.2006.09.32317092682","DOI":"10.1016\/j.ijdevneu.2006.09.323"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_023_w2aab3b7c14b1b6b1ab1b5c23Aa","doi-asserted-by":"crossref","unstructured":"Nishimura T, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PLoS One 2008;3:e2558.1859692710.1371\/journal.pone.0002558","DOI":"10.1371\/journal.pone.0002558"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_024_w2aab3b7c14b1b6b1ab1b5c24Aa","doi-asserted-by":"crossref","unstructured":"Cornish S, Mehl-Madrona L. The role of vitamins and minerals in psychiatry. Integr Med Insights 2008;3:117.","DOI":"10.4137\/117863370800300003"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_025_w2aab3b7c14b1b6b1ab1b5c25Aa","doi-asserted-by":"crossref","unstructured":"Tsang CK, Ina A, Goto T, Kamei Y. Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells. Neuroscience. 2005;132:633\u201343.10.1016\/j.neuroscience.2005.01.02815837125","DOI":"10.1016\/j.neuroscience.2005.01.028"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_026_w2aab3b7c14b1b6b1ab1b5c26Aa","doi-asserted-by":"crossref","unstructured":"Tsang CK, Kamei Y. Sargaquinoic acid supports the survival of neuronal PC12D cells in a nerve growth factor-independent manner. Eur J Pharmacol 2004;488:11\u20138.10.1016\/j.ejphar.2004.01.033","DOI":"10.1016\/j.ejphar.2004.01.033"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_027_w2aab3b7c14b1b6b1ab1b5c27Aa","doi-asserted-by":"crossref","unstructured":"Vreugdenhil M, Bruehl C, Voskuyl RA, Kang JX, Leaf A, Wadman WJ. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Proc Natl Acad Sci 1996;93:12559\u201363.10.1073\/pnas.93.22.12559","DOI":"10.1073\/pnas.93.22.12559"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_028_w2aab3b7c14b1b6b1ab1b5c28Aa","doi-asserted-by":"crossref","unstructured":"Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, et al. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999;56:407\u201312.10.1001\/archpsyc.56.5.40710232294","DOI":"10.1001\/archpsyc.56.5.407"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_029_w2aab3b7c14b1b6b1ab1b5c29Aa","doi-asserted-by":"crossref","unstructured":"Leaf A, Kang JX, Xiao Y-F, Billman GE, Voskuyl RA. The antiarrhythmic and anticonvulsant effects of dietary N-3 fatty acids. J Membr Biol 1999;172:1\u201311.10.1007\/s00232990057810552009","DOI":"10.1007\/s002329900578"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_030_w2aab3b7c14b1b6b1ab1b5c30Aa","doi-asserted-by":"crossref","unstructured":"Jeong DH, Kim KB, Kim MJ, Kang BK, Ahn DH. Anti-inflammatory activity of ethanolic extract of Sargassum micracanthum. J Microbiol Biotechnol. 2013;23:1691\u20138.2426265510.4014\/jmb.1311.11025","DOI":"10.4014\/jmb.1311.11025"},{"key":"2025121209252836130_j_jcim-2018-0207_ref_031_w2aab3b7c14b1b6b1ab1b5c31Aa","doi-asserted-by":"crossref","unstructured":"M\u00fcller N, Schwarz MJ, Dehning S, Douhe A, Cerovecki A, Goldstein-M\u00fcller B, et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry 2006;11:680.10.1038\/sj.mp.400180516491133","DOI":"10.1038\/sj.mp.4001805"}],"container-title":["Journal of Complementary and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jcim.2019.16.issue-4\/jcim-2018-0207\/jcim-2018-0207.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2018-0207\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2018-0207\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:26:41Z","timestamp":1765542401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2018-0207\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,5,24]]},"published-print":{"date-parts":[[2019,12,18]]}},"alternative-id":["10.1515\/jcim-2018-0207"],"URL":"https:\/\/doi.org\/10.1515\/jcim-2018-0207","relation":{},"ISSN":["1553-3840","2194-6329"],"issn-type":[{"value":"1553-3840","type":"electronic"},{"value":"2194-6329","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,24]]},"article-number":"20180207"}}