{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:33:55Z","timestamp":1777602835102,"version":"3.51.4"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2019-0016_s_001a_w2aab3b8c83b1b7b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interferon-\u03b1 (IFN\u03b1) therapy causes psychiatric side effects, including depression that may result in poor compliance of therapy. It is important to find alternative therapies for the prevention of IFN\u03b1 induced depression. Non-steroidal anti-inflammatory drugs (NSAIDs) have been useful in depressive disorder. Therefore the effects of celecoxib, ibuprofen, and indomethacin were evaluated following IFN\u03b1-induced depression in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0016_s_002a_w2aab3b8c83b1b7b1aab1c14b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male albino mice weighing 26\u2009\u00b1\u20092\u2006g were used. Depression was induced by IFN\u03b1 (16\u2009\u00d7\u200910\n                      <jats:sup>5<\/jats:sup>\n                      IU\/kg, SC) for six consecutive days. Animals were first subject to the locomotor test, then the splash test and finally the forced swimming test (FST) on the 7th day. The NSAIDs were administered (IP) either one single dose before the test, or simultaneously with IFN\u03b1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0016_s_003a_w2aab3b8c83b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>locomotor activity was only impaired by ibuprofen high dose (75\u2009mg\/kg), thus it was not further evaluated. Following IFN\u03b1 therapy depression-like behaviors were observed; significant changes during the splash test (grooming time 24\u2006\u00b1\u20097\u2006sec vs. control 63\u2006\u00b1\u20097\u2006sec), the FST (immobility time 166\u2006\u2009\u00b1\u200915\u2006sec vs. control 128\u2006\u2009\u00b1\u20096\u2006sec), and sucrose preference reduced to 64\u2009\u00b1\u20090.8%. The NSAIDs noticeably reduced the immobility time in FST, while grooming time was increased. Celecoxib and indomethacin single doses were effective while ibuprofen showed better antidepressant effects when it was administered along with IFN\u03b1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0016_s_004a_w2aab3b8c83b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The NSAIDs were able to prevent IFN\u03b1 induced depression in mice. NSAIDs administration with IFN\u03b1 does not interfere with clinical benefit effects of IFN\u03b1 and they could also be useful to prevent IFN\u03b1 psychiatric side effects, thus further clinical trials are suggested.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2019-0016","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T07:26:22Z","timestamp":1566026782000},"source":"Crossref","is-referenced-by-count":27,"title":["Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice"],"prefix":"10.1515","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-5581","authenticated-orcid":false,"given":"Azadeh","family":"Mesripour","sequence":"first","affiliation":[{"name":"Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical sciences , Isfahan university of Medical Sciences , Isfahan , Iran"},{"name":"Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical sciences , Isfahan university of Medical Sciences , Isfahan , 81746-73461 , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrzad","family":"Shahnooshi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical sciences , Isfahan university of Medical Sciences , Isfahan , 81746-73461 , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valiollah","family":"Hajhashemi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical sciences , Isfahan university of Medical Sciences , Isfahan , 81746-73461 , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"key":"2025121209265789658_j_jcim-2019-0016_ref_001_w2aab3b8c83b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Asnis GM, De La GR. 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