{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:05:09Z","timestamp":1768003509345,"version":"3.49.0"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Max Biocare Pty. Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2019-0074_abs_001_w2aab3b7c29b1b6b1aab1c16b2Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To evaluate the safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (\n                      <jats:italic>GoutFighter<\/jats:italic>\n                      <jats:sup>TM<\/jats:sup>\n                      ) for gout management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0074_abs_002_w2aab3b7c29b1b6b1aab1c16b3Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single arm, open-label pilot study was conducted at the National Hospital for Traditional Medicine in Vietnam. Participants (n=35 recruited) diagnosed with chronic gout received four tablets of\n                      <jats:italic>GoutFighter<\/jats:italic>\n                      <jats:sup>TM<\/jats:sup>\n                      daily over a 45-day period. Efficacy was assessed by changes in pain, swelling and blood uric acid levels, with concurrent safety and tolerability assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0074_abs_003_w2aab3b7c29b1b6b1aab1c16b4Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 27 (85.2% male) participants (mean\u00a0\u00b1\u00a0SD age, 54.2\u00a0\u00b1\u00a012.5 years; BMI, 24.2\u00a0\u00b1\u00a03.6\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) with gout (median [IQR], years since diagnosis 4.0 [3.0\u20138.0]) completed intervention. In relation to safety, there were no significant changes in vital signs, blood biochemistry or cell counts. In regard to efficacy, the degree of perceived pain and frequency of joint swelling significantly declined after 15 and 30 days of treatment, respectively, and remained so until the end of trial. Mean blood uric acid levels also declined by 25.8\u00a0\u03bcmol\/L (95% CI, 3.7 to 48.0, p=0.024). Overall, the predominance of participants (96.3%) responded favorably to treatment (p&lt;0.0001) and\n                      <jats:italic>GoutFighter<\/jats:italic>\n                      <jats:sup>TM<\/jats:sup>\n                      was well tolerated, with no serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0074_abs_004_w2aab3b7c29b1b6b1aab1c16b5Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Clinically relevant doses of\n                      <jats:italic>GoutFighter<\/jats:italic>\n                      <jats:sup>TM<\/jats:sup>\n                      were found to be generally safe, well-tolerated and effective for the short-term, symptomatic relief of chronic gout.\n                      <jats:italic>GoutFighter<\/jats:italic>\n                      <jats:sup>TM<\/jats:sup>\n                      appears to be suitable as an adjunctive treatment in lifestyle programs for gout management, and further investigation in placebo-controlled trials is therefore warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2019-0074","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T12:32:06Z","timestamp":1590496326000},"page":"113-121","source":"Crossref","is-referenced-by-count":3,"title":["Safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (\n                    <i>GoutFighter<\/i>\n                    <sup>TM<\/sup>\n                    ) for gout: a single-arm open-label pilot study"],"prefix":"10.1515","volume":"18","author":[{"given":"Nam","family":"Vu","sequence":"first","affiliation":[{"name":"National Hospital of Traditional Medicine , Hanoi , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuan","family":"Thi Tam Nguyen","sequence":"additional","affiliation":[{"name":"National Hospital of Traditional Medicine , Hanoi , Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Haddon Parmenter","sequence":"additional","affiliation":[{"name":"Research and Innovation Platform , Max Biocare Institute , Melbourne , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Anthony","family":"Thouas","sequence":"additional","affiliation":[{"name":"Max Biocare Institute , Research and Innovation Platform , Level 1-2, 667 Chapel St, South Yarra , Melbourne, Victoria, 3141 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"2025121209203446731_j_jcim-2019-0074_ref_001_w2aab3b7c29b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Smith E, Hoy D, Cross M, Merriman TR, Vos T, Buchbinder R, et al. 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