{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:14:30Z","timestamp":1769634870979,"version":"3.49.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2019-0085_s_020_w2aab3b7c47b1b6b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type II diabetes, a multifactorial progressive disorder is the prime concern of the twenty-first century. Modern medicine is proven effective in delaying the effects of diabetes. However, the side effects are amplified over time. In order to find relief from side effects, people are rigorously searching for alternative treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0085_s_021_w2aab3b7c47b1b6b1aab1c14b2Aa\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      In this study, we aim to identify the bioactive components in the\n                      <jats:italic>Coldenia procumbens<\/jats:italic>\n                      L. and assess its anti-diabetic effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0085_s_022_w2aab3b7c47b1b6b1aab1c14b3Aa\">\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Initially, the plant was extracted using chloroform and methanol. Both the extracts were analysed using IR Spectrum and NMR. The methanol extract of\n                      <jats:italic>Coldenia procumbens<\/jats:italic>\n                      L. was assessed for its anti-hyperglycaemic activity against streptozotocin induced animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0085_s_023_w2aab3b7c47b1b6b1aab1c14b4Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IR spectrum of the extracts was compared with standard compounds and four compounds, \u03b1-amyrin, \u03b2-sitosterol, \u03b2-stigmasterol and wedelolactone was identified. Methanol extract of\n                      <jats:italic>Coldenia procumbens<\/jats:italic>\n                      L. decreased glucose levels in serum and enzymes levels. Histopathology of pancreas showed excellent recovery from the damage induced by streptozotocin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0085_s_024_w2aab3b7c47b1b6b1aab1c14b5Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The compounds identified in\n                      <jats:italic>Coldenia procumbens<\/jats:italic>\n                      L. have significant anti-diabetic, insulin mimetic and insulin secretory activities with their complete mechanisms already studied in detail. Also,\n                      <jats:italic>Coldenia procumbens<\/jats:italic>\n                      L. methanol extract showed significant anti-hyperglycaemic activity. The plant should be further studied to be developed as an alternative medicine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2019-0085","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T04:08:28Z","timestamp":1586837308000},"source":"Crossref","is-referenced-by-count":4,"title":["Identification of bioactive constituents in\n                    <i>Coldenia procumbens<\/i>\n                    L. and its antidiabetic activity against streptozotocin induced Wistar albino rats"],"prefix":"10.1515","volume":"17","author":[{"given":"Ganesan","family":"Rethinam","sequence":"first","affiliation":[{"name":"Biochemistry , Central Council for Research in Siddha , Chennai , Tamil Nadu 600106 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathuram","family":"Venkatanarasimhan","sequence":"additional","affiliation":[{"name":"Chemistry , Captain Sriniwasa Murthy Drug Research Institute for Ayurveda Chennai , Chennai , Tamil Nadu 600106 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"2025121209305185496_j_jcim-2019-0085_ref_001_w2aab3b7c47b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Tiwari P. Recent trends in therapeutic approaches for diabetes management: a comprehensive update. J Diab Res 2015;2015:11.","DOI":"10.1155\/2015\/340838"},{"key":"2025121209305185496_j_jcim-2019-0085_ref_002_w2aab3b7c47b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Rowley WR, Bezold C, Arikan Y, Byrne E, Krohe S. Diabetes 2030: insights from yesterday, today, and future trends. Popul Health Manag 2017;20:6\u201312.","DOI":"10.1089\/pop.2015.0181"},{"key":"2025121209305185496_j_jcim-2019-0085_ref_003_w2aab3b7c47b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Animaw W, Seyoum Y. Increasing prevalence of diabetes mellitus in a developing country and its related factors. PLoS One 2017;12:e0187670.","DOI":"10.1371\/journal.pone.0187670"},{"key":"2025121209305185496_j_jcim-2019-0085_ref_004_w2aab3b7c47b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Skyler JS, Bakris GL, Bonifacio E, Darsow T, Eckel RH, Groop L, et al. 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