{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:21:40Z","timestamp":1791141700724,"version":"4.1.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2019-0289_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The use of\n                      <jats:italic>Spathodea campanulata<\/jats:italic>\n                      in folklore medicine for the management of reproductive disorders has been poorly reported. We sought to investigate the protective potential of the ethyl acetate fraction of\n                      <jats:italic>S.\u00a0campanulata<\/jats:italic>\n                      stem bark extract (EFSC) on lead acetate-induced (LA) testicular toxicity in male rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0289_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Animals during a 28\u00a0days treatment received dimethyl sulfoxide (DMSO, 0.1%), LA (20\u00a0mg\/kg), and EFSC (200\u00a0mg\/kg). Others received EFSC only (100, 200, and 400\u00a0mg\/kg) or vitamin E (100\u00a0mg\/kg) 1\u00a0h prior to LA (20\u00a0mg\/kg) administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0289_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LA administration decreased sperm counts and motility by 36.39 and 40.69% respectively in rats. Also, LA-untreated rats showed elevated malondialdehyde (MDA) and decreased total proteins in testis (260, 33%) and epididymis (62, 29%) respectively. However, EFSC (100, 200, or 400\u00a0mg\/kg) administrations improved sperm morphological characteristics as well as antioxidant status in LA-treated rats. EFSC (400\u00a0mg\/kg) showed improved testis seminiferous tubules that were almost normal in the LA-treated rats. Further, EFSC contains a high 9-octadecenoic acid methyl ester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2019-0289_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, evidence by LA-induced testicular toxicity, EFSC provides chemopreventive roles via antioxidant mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2019-0289","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T17:57:59Z","timestamp":1620842279000},"page":"19-26","source":"Crossref","is-referenced-by-count":6,"title":["Ethyl acetate fraction of\n                    <i>Spathodea campanulata<\/i>\n                    (\n                    <i>Bignoniaceae<\/i>\n                    ) attenuates lead acetate induced testicular toxicity in male Wistar rats"],"prefix":"10.1515","volume":"19","author":[{"given":"Glory Olubusayo","family":"Adesiyan","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Benjamin S. Carson (Snr.) School of Medicine, Babcock University , Ilishan-Remo , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope Olaoluwa","family":"Talabi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Benjamin S. Carson (Snr.) School of Medicine, Babcock University , Ilishan-Remo , Ogun State , Nigeria"},{"name":"Department of Biochemistry , College of Medicine , University of Lagos , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-1723","authenticated-orcid":false,"given":"Oluwafemi Ezekiel","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Benjamin S. Carson (Snr.) School of Medicine, Babcock University , Ilishan-Remo , Ogun State , Nigeria"},{"name":"Department of Pharmacology , Therapeutics and Toxicology , Obafemi Awolowo College of Health Sciences , PMB 2001 Sagamu Campus , Olabisi Onabanjo University , Ilishan-Remo , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitope Funmi","family":"Ogundare","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Benjamin S. Carson (Snr.) School of Medicine, Babcock University , Ilishan-Remo , Ogun State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"2025121209222494238_j_jcim-2019-0289_ref_001","doi-asserted-by":"crossref","unstructured":"Sen, S, Chakraborty, R. Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: importance, challenges and future. 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