{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:43:23Z","timestamp":1787672603893,"version":"build-2736575974"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2020-0129_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The quality of management of hyperuricemia has remained sub-optimal owing to unavoidable toxicities, limitations, and dearth of novel advances. Homeopathy has remained under-researched in hyperuricemia. We investigated the clinical effectiveness of three treatment regimens\u00a0\u2013 individualized homeopathy (IH),\n                      <jats:italic>Urtica urens<\/jats:italic>\n                      mother tincture (UUMT), and both (IH\u00a0+\u00a0UUMT) along with lifestyle modifications in a sample of 90 patients with hyperuricemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0129_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An open, randomized (1:1:1), 3 parallel arms (IH, UUMT, and IH\u00a0+\u00a0UUMT), pragmatic trial was conducted at National Institute of Homoeopathy, Kolkata. Outcome measures were serum uric acid (primary), Gout Assessment Questionnaire version 2 (GAQ2, secondary), and Measure Yourself Medical Outcome Profile version 2 (MYMOP2, secondary); all measured at baseline, and after 3 and 6\u00a0months. Intention- to-treat sample was analyzed to detect group differences by unpaired t tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0129_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Attrition rate was 8.9% (IH: 3, UUMT: 3, IH\u00a0+\u00a0UUMT: 2). Groups were comparable at baseline. Reductions in serum uric acid over 3\u00a0months were comparatively higher (p=0.057) in the UUMT group than others, however, the differences were narrowed over 6\u00a0months (p=0.119). Per protocol analysis of serum uric acid level revealed similar trend of significantly higher reduction in the UUMT group than the other two (3\u00a0months: p=0.001; 6\u00a0months: p=0.007). No significant differences existed in reductions of GAQ2 scores among the three groups. Few significant differences were detected in MYMOP scores over 3\u00a0months favoring IH against others (symptom 2, p=0.001 and wellbeing score, p=0.002), and also over 6\u00a0months favoring IH\u00a0+\u00a0UUMT against others (symptom 1, p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0129_abs_004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although all three therapies showed similar improvements, the IH\u00a0+\u00a0UUMT group had more positive direction of effects than IH or UUMT alone; however, no definite conclusion could be arrived at. Further trials are warranted with larger sample size. Trial registration: CTRI\/2018\/05\/014026.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2020-0129","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T01:37:16Z","timestamp":1603503436000},"page":"599-608","source":"Crossref","is-referenced-by-count":10,"title":["Individualized homeopathic medicines and\n                    <i>Urtica urens<\/i>\n                    mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial"],"prefix":"10.1515","volume":"18","author":[{"given":"Chintamani","family":"Nayak","sequence":"first","affiliation":[{"name":"Shree Guru Gobind Singh Tricentenary University , Gurgaon , Gurugram , Haryana 122505 , India"},{"name":"Dept. of Materia Medica , National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India , Block GE , Sector 3 , Salt Lake , Kolkata 700106 , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivedita","family":"Pattanaik","sequence":"additional","affiliation":[{"name":"Dept. of Materia Medica , Rajasthan Vidyapeeth Homoeopathic Medical College and Hospital , Udaipur , Rajasthan , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Dept. of Materia Medica , National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India , Block GE , Sector 3 , Salt Lake , Kolkata 700106 , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankhuri","family":"Misra","sequence":"additional","affiliation":[{"name":"Dept. of Materia Medica , National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India , Block GE , Sector 3 , Salt Lake , Kolkata 700106 , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koushik","family":"Bhar","sequence":"additional","affiliation":[{"name":"Dept. of Materia Medica , National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India , Block GE , Sector 3 , Salt Lake , Kolkata 700106 , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Michael","sequence":"additional","affiliation":[{"name":"Dept. of Organon of Medicine and Homoeopathic Philosophy , National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India , Kolkata , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Koley","sequence":"additional","affiliation":[{"name":"Champsara , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-5265","authenticated-orcid":false,"given":"Subhranil","family":"Saha","sequence":"additional","affiliation":[{"name":"Howrah , West Bengal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"2025121209123708583_j_jcim-2020-0129_ref_001","unstructured":"Billa, G, Dargad, R, Mehta, A. 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