{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:41:27Z","timestamp":1765539687110,"version":"3.48.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2020-0276_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Stress responses vary throughout pregnancy and impact of late gestational variable stress (LGVS) with vitamin C supplementation on uterine contractility is barely explored. This study investigates fetal weight outcome and\n                      <jats:italic>in-vitro<\/jats:italic>\n                      uterine contractile responses to pharmacological agents during LGVS exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0276_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty four nulliparous pregnant rats were divided into four groups of six. During gestation days 10\u201319, groups 1 &amp; 2 received normal saline and vitamin C (10\u00a0mg\/kg) respectively. Groups 3 and 4 were exposed to stress (sleep deprivation, predator exposure, immobility, rapid cage changes, noise, and foreign object) with group 4 concurrently supplemented with vitamin C (10\u00a0mg\/kg). Serum cortisol, oxidative bio-markers, fetal weights and\n                      <jats:italic>in-vitro<\/jats:italic>\n                      contractile responses of excised uterine tissue to acetylcholine (Ach), oxytocin, calcium chloride (CaCl\n                      <jats:sub>2<\/jats:sub>\n                      ), potassium chloride (KCl), diclofenac, and magnesium ions were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0276_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Malondialdehyde activity and cortisol were significantly increased in variable stress only exposed group when compared with control and vitamin C supplemented groups. Fetal body weights, superoxide dismutase and catalase activity were significantly reduced in variable stress only exposed group. Significantly impaired contractile responses to Ach, CaCl\n                      <jats:sub>2<\/jats:sub>\n                      &amp; KCl in variable stress only exposed group were modulated in vitamin C supplemented groups. Impaired contractile response to oxytocin was however not reversed. Relaxation responses to diclofenac and magnesium ions were statistically unaltered across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0276_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Impaired fetal weights and uterine contractile activity to Ach, CaCl\n                      <jats:sub>2<\/jats:sub>\n                      and KCl during LGVS was modulated by vitamin C supplementation. Impaired oxytocin contractile activity was however unreversed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2020-0276","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T22:30:11Z","timestamp":1620772211000},"page":"745-751","source":"Crossref","is-referenced-by-count":0,"title":["Uterine contractile activity and fetal outcome in rats treated with vitamin C during late gestational variable stress exposure"],"prefix":"10.1515","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-8999","authenticated-orcid":false,"given":"Shakiru A.","family":"Salami","sequence":"first","affiliation":[{"name":"Department of Physiology , Lagos State University College of Medicine , Ikeja , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein M.","family":"Salahdeen","sequence":"additional","affiliation":[{"name":"Department of Physiology , Lagos State University College of Medicine , Ikeja , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abidemi E.","family":"Obafemi","sequence":"additional","affiliation":[{"name":"Department of Physiology , Lagos State University College of Medicine , Ikeja , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babatunde A.","family":"Murtala","sequence":"additional","affiliation":[{"name":"Department of Physiology , Lagos State University College of Medicine , Ikeja , Lagos State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"2025121209073072615_j_jcim-2020-0276_ref_001","unstructured":"Salami, SA, Itoadon, DI, Salahdeen, HM, Murtala, BA. Gestational hormones and oxidative biomarker changes to ascorbic acid supplementation during unpredictable variable stress exposure in pregnant Wistar rats. Arch Pharmacol 2020;1:162\u201373."},{"key":"2025121209073072615_j_jcim-2020-0276_ref_002","unstructured":"Salami, SA, Salahdeen, HM, Obafemi, AE, Murtala, BA. Attenuation of impaired uterine contractile activity by ascorbic acid supplementation during early gestational variable stress exposure in Wistar rats. J Afr Assoc Physiol Sci 2020;8:16\u201322."},{"key":"2025121209073072615_j_jcim-2020-0276_ref_003","unstructured":"Challis, JRG, Lye, SJ. Parturition. In: Knobil, E, Neill, JD, editors. The physiology of reproduction. New York: Raven Press, Ltd; 1994:985\u20131031 pp."},{"key":"2025121209073072615_j_jcim-2020-0276_ref_004","doi-asserted-by":"crossref","unstructured":"Benfield, RD, Newton, ER, Tanner, CJ, Heitkemper, MM. Cortisol as a biomarker of stress in term human labor: physiological and methodological issues. 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