{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:26:38Z","timestamp":1765538798519,"version":"3.48.0"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2020-0301_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Gout is an inflammatory response to the Monosodium urate crystals formed secondary to hyperuricaemia. The prevalence of gout has increased in recent years. The current conventional medical management aims at symptomatic management. In Ayurveda, gouty arthritis has similarity to\n                      <jats:italic>Vata-Pittadhika Vatarakta<\/jats:italic>\n                      , owing to its comparable aetiology and clinical features and treatment was planned accordingly. The present study is designed to evaluate the combined effect of Ayurvedic formulations and therapy in reducing the signs and symptoms and uric acid level in Gouty Arthritis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0301_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study was a single group pre\u2013post test design. The patients diagnosed on the basis of ACR EULAR Gout classification 2015 criteria. They were given\n                      <jats:italic>Guduchi Siddha Ksheeravasthi<\/jats:italic>\n                      (Therapeutic enema),\n                      <jats:italic>Guduchi<\/jats:italic>\n                      (\n                      <jats:italic>Tinospora cordifolia<\/jats:italic>\n                      )\n                      <jats:italic>Kashaya<\/jats:italic>\n                      (diluted decoction) and\n                      <jats:italic>Punarnava Guggulu<\/jats:italic>\n                      . Assessment of pain was done by Visual Analogue Scale and serum uric acid level was assessed on day 1 and on 31st day. Also, the change in symptoms were analyzed before and after the treatment. This study has been registered in the clinical trial registry-India.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0301_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The obtained data were evaluated using paired t-test and Wilcoxon signed rank test. A significant improvement (p=0.0001) was observed in VAS scale (98.77%), serum uric acid levels (57.81%), subjective parameters. Moreover, erythrocyte sedimentation rate was observed to be normal level as compared to baseline of the therapy also with an enhancement of hemoglobin (Hb) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2020-0301_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thus, the present study revealed that Ayurvedic therapeutic interventions can play a major role in the management of gouty arthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2020-0301","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T04:16:18Z","timestamp":1620792978000},"page":"278-283","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Ayurvedic treatment protocol in gouty arthritis\u00a0\u2013 a clinical study"],"prefix":"10.1515","volume":"20","author":[{"given":"Aswathi Rajan","family":"Vaprath Kuniyil","sequence":"first","affiliation":[{"name":"Department of Kayachikitsa , Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham , Kollam , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devipriya","family":"Soman","sequence":"additional","affiliation":[{"name":"Department of Kayachikitsa , Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham , Kollam , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh C.","family":"Kundagol","sequence":"additional","affiliation":[{"name":"Department of Kayachikitsa , Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham , Kollam , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Chacko","sequence":"additional","affiliation":[{"name":"Department of Kayachikitsa , Amrita School of Ayurveda, Amritapuri, Amrita Vishwa Vidyapeetham , Kollam , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"unstructured":"Krishna Das, KV. Textbook of medicine, chapter: 114 (metabolic arthropathies), 6th ed., vol I:772\u20135 pp.","key":"2025121209005870562_j_jcim-2020-0301_ref_001"},{"unstructured":"Pal Munjal, Y. API textbook of medicine, chapter 5 (Gout and other crystal arthritides), 10th ed.; 2015, vol 2:2483 pp.","key":"2025121209005870562_j_jcim-2020-0301_ref_002"},{"unstructured":"Karan Sharma, R, Bagavan Dash, V. Agnivesha Charaka Samhita, vol 5, Chikitsa Sthana, 29th chapter, 26th ed., Chaukhambha Sanskrit Series; 2000.","key":"2025121209005870562_j_jcim-2020-0301_ref_003"},{"unstructured":"Acharya, VYT. Agnivesa Charaka Samhita; Siddhisthana, 8th Chapter. Chaukhambha Publications: edition; 2016.","key":"2025121209005870562_j_jcim-2020-0301_ref_004"},{"unstructured":"Sharma, PV. Cakradatta. Edited & translated by Priya Vrat Sharma; 23 chapter of Vatarakta Chikitsa. 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