{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:45:45Z","timestamp":1791870345348,"version":"4.3.4"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2021-0159_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The effects of intra-ventral hippocampal memantine administration in male NMRI stressed mice were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2021-0159_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two stainless steel gauge 23 guide cannulas were placed in the middle part of the mice ventral hippocampus using stereotaxic coordination. Seven days later, the animals were undergone to the stress protocol as follows: They experience four consecutive electro-foot shock stress sessions lasting for 10\u00a0min. Five or 30\u00a0min before each stress session, the animals received intra-ventral hippocampal (0.1, 1 and, 5\u00a0\u00b5g\/mouse) or intraperitoneal (1,\u00a05, and 10\u00a0mg\/kg) memantine respectively. Eight days after stress termination, the animals were tested either for the maintenance of either anxiety (elevated plus maze) or depression (forced swimming test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2021-0159_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Animals show anxiety eight days after stress termination. Intra-ventral hippocampal infusion of memantine (5\u00a0\u00b5g\/mouse) 5\u00a0min before stress inhibited the anxiety-like behaviors. However, other doses of the drug exacerbate the stress effect. The drug, when injected peripherally exacerbated the stress effect in all doses. The drug by itself had no effect. In addition, animals also show depression nine days after stress termination and memantine (0.1, 1, and 5\u00a0\u00b5g\/mouse) reduced the stress effect. The drug (0.1\u00a0\u00b5g\/mouse) by itself induced depression in the animals. However, the drug when injected peripherally reduced the stress effect in all doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2021-0159_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It could be concluded that NMDA glutamate receptors in the ventral hippocampus may play a pivotal role in the mediation of maintenance of anxiety and depression induced by stress in the mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2021-0159","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T21:42:42Z","timestamp":1631828562000},"page":"581-589","source":"Crossref","is-referenced-by-count":2,"title":["Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice"],"prefix":"10.1515","volume":"19","author":[{"given":"Mohammad","family":"Sahraei","sequence":"first","affiliation":[{"name":"School of Dentistry , Shahid Beheshti University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedayat","family":"Sahraei","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoomeh","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Biology , North Tehran Branch, Islamic Azad University , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Khosravi","sequence":"additional","affiliation":[{"name":"Department of Biology , North Tehran Branch, Islamic Azad University , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin","family":"Ganjkhani","sequence":"additional","affiliation":[{"name":"Department of Physiology , School of Medicine, Zanjan University of Medical Sciences , Zanjan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholam Hossein","family":"Meftahi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"2026101305050410305_j_jcim-2021-0159_ref_001","doi-asserted-by":"crossref","unstructured":"McEwen, BS, Akil, H. Revisiting the stress concept: implications for affective disorders. J Neurosci 2020;40:12\u201321. https:\/\/doi.org\/10.1523\/jneurosci.0733-19.2019.","DOI":"10.1523\/JNEUROSCI.0733-19.2019"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_002","doi-asserted-by":"crossref","unstructured":"McEwen, BS, Eiland, L, Hunter, RG, Miller, MM. Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology 2012;62:3\u201312. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.07.014.","DOI":"10.1016\/j.neuropharm.2011.07.014"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_003","unstructured":"Boyle, LM. A neuroplasticity hypothesis of chronic stress in the basolateral amygdala. Yale J Biol Med 2013;86:117."},{"key":"2026101305050410305_j_jcim-2021-0159_ref_004","doi-asserted-by":"crossref","unstructured":"McEwen, BS, Nasca, C, Gray, JD. Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology 2016;41:3. https:\/\/doi.org\/10.1038\/npp.2015.171.","DOI":"10.1038\/npp.2015.171"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_005","doi-asserted-by":"crossref","unstructured":"Popoli, M, Yan, Z, McEwen, BS, Sanacora, G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci 2012;13:22\u201337. https:\/\/doi.org\/10.1038\/nrn3138.","DOI":"10.1038\/nrn3138"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_006","doi-asserted-by":"crossref","unstructured":"McEwen, BS. Effects of adverse experiences for brain structure and function. Biol Psychiatr 2000;48:721\u201331. https:\/\/doi.org\/10.1016\/s0006-3223(00)00964-1.","DOI":"10.1016\/S0006-3223(00)00964-1"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_007","doi-asserted-by":"crossref","unstructured":"Nasca, C, Bigio, B, Zelli, D, Nicoletti, F, McEwen, BS. Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility. Mol Psychiatr 2015;20:755\u201363. https:\/\/doi.org\/10.1038\/mp.2014.96.","DOI":"10.1038\/mp.2014.96"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_008","doi-asserted-by":"crossref","unstructured":"Nasca, C, Zelli, D, Bigio, B, Piccinin, S, Scaccianoce, S, Nistic\u00f2, R, et al.. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. Proc Natl Acad Sci Unit States Am 2015;112:14960\u20135. https:\/\/doi.org\/10.1073\/pnas.1516016112.","DOI":"10.1073\/pnas.1516016112"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_009","doi-asserted-by":"crossref","unstructured":"Calabrese, F, Guidotti, G, Molteni, R, Racagni, G, Mancini, M, Riva, MA. Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment. PloS One 2012;7:e37916. https:\/\/doi.org\/10.1371\/journal.pone.0037916.","DOI":"10.1371\/journal.pone.0037916"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_010","doi-asserted-by":"crossref","unstructured":"Swanson, CJ, Bures, M, Johnson, MP, Linden, AM, Monn, JA, Schoepp, DD. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov 2005;4:131\u201344. https:\/\/doi.org\/10.1038\/nrd1630.","DOI":"10.1038\/nrd1630"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_011","doi-asserted-by":"crossref","unstructured":"Li, N, Liu, RJ, Dwyer, JM, Banasr, M, Lee, B, Son, H, et al.. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatr 2011;69:754\u201361. https:\/\/doi.org\/10.1016\/j.biopsych.2010.12.015.","DOI":"10.1016\/j.biopsych.2010.12.015"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_012","doi-asserted-by":"crossref","unstructured":"Maeng, S, Zarate, CA. The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. Curr Psychiatr Rep 2007;9:467\u201374. https:\/\/doi.org\/10.1007\/s11920-007-0063-1.","DOI":"10.1007\/s11920-007-0063-1"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_013","doi-asserted-by":"crossref","unstructured":"Schwartz, TL, Siddiqui, UA, Raza, S. Memantine as an augmentation therapy for anxiety disorders. Case Rep Psychiatry 2012;2012:749796. https:\/\/doi.org\/10.1155\/2012\/749796.","DOI":"10.1155\/2012\/749796"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_014","doi-asserted-by":"crossref","unstructured":"Parsons, C, Danysz, W, Quack, G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist\u2014a review of preclinical data. Neuropharmacology 1999;38:735\u201367. https:\/\/doi.org\/10.1016\/s0028-3908(99)00019-2.","DOI":"10.1016\/S0028-3908(99)00019-2"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_015","doi-asserted-by":"crossref","unstructured":"Kos, T, Popik, PA. Comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice. Behav Pharmacol 2005;16:155\u201361. https:\/\/doi.org\/10.1097\/00008877-200505000-00004.","DOI":"10.1097\/00008877-200505000-00004"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_016","doi-asserted-by":"crossref","unstructured":"Amidfar, M, R\u00e9us, GZ, Quevedo, J, Kim, YK. The role of memantine in the treatment of major depressive disorder: clinical efficacy and mechanisms of action. Eur J Pharmacol 2018;827:103\u201311. https:\/\/doi.org\/10.1016\/j.ejphar.2018.03.023.","DOI":"10.1016\/j.ejphar.2018.03.023"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_017","doi-asserted-by":"crossref","unstructured":"Reisberg, B, Doody, R, St\u00f6ffler, A, Schmitt, F, Ferris, S, M\u00f6bius, HJ. Memantine in moderate-to-severe Alzheimer\u2019s disease. N Engl J Med 2003;348:1333\u201341. https:\/\/doi.org\/10.1056\/nejmoa013128.","DOI":"10.1056\/NEJMoa013128"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_018","doi-asserted-by":"crossref","unstructured":"R\u00e9us, GZ, Abelaira, HM, Stringari, RB, Fries, GR, Kapczinski, F, Quevedo, J. Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats. Metab Brain Dis 2012;27:175\u201382. https:\/\/doi.org\/10.1007\/s11011-012-9281-2.","DOI":"10.1007\/s11011-012-9281-2"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_019","unstructured":"Osanloo, N, Sarahian, N, Zardooz, H, Sahraei, H, Sahraei, M, Sadeghi, B. Effects of memantine, an NMDA antagonist, on metabolic syndromes in female NMRI mice. Basic Clin Neurosci 2015;6:239."},{"key":"2026101305050410305_j_jcim-2021-0159_ref_020","doi-asserted-by":"crossref","unstructured":"Ehteram, BZ, Sahraei, H, Meftahi, GH, Khosravi, M. Effect of intermittent feeding on gonadal function in male and female NMRI mice during chronic stress. Braz Arch Biol Technol 2017;60:e17160607. https:\/\/doi.org\/10.1590\/1678-4324-2017160607.","DOI":"10.1590\/1678-4324-2017160607"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_021","doi-asserted-by":"crossref","unstructured":"Smith, KL, Rao, RR, Vel\u00e1zquez-S\u00e1nchez, C, Valenza, M, Giuliano, C, Everitt, BJ, et al.. The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell. Neuropsychopharmacology 2015;40:1163\u201371. https:\/\/doi.org\/10.1038\/npp.2014.299.","DOI":"10.1038\/npp.2014.299"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_022","doi-asserted-by":"crossref","unstructured":"Thompson, CL, Pathak, SD, Jeromin, A, Ng, LL, MacPherson, CR, Mortrud, MT, et al.. Genomic anatomy of the hippocampus. Neuron 2008;60:1010\u201321. https:\/\/doi.org\/10.1016\/j.neuron.2008.12.008.","DOI":"10.1016\/j.neuron.2008.12.008"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_023","doi-asserted-by":"crossref","unstructured":"Fanselow, MS, Dong, HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 2010;65:7\u201319. https:\/\/doi.org\/10.1016\/j.neuron.2009.11.031.","DOI":"10.1016\/j.neuron.2009.11.031"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_024","doi-asserted-by":"crossref","unstructured":"Kjelstrup, KG, Tuvnes, FA, Steffenach, HA, Murison, R, Moser, EI, Moser, MB. Reduced fear expression after lesions of the ventral hippocampus. Proc Natl Acad Sci USA 2002;99:10825\u201330. https:\/\/doi.org\/10.1073\/pnas.152112399.","DOI":"10.1073\/pnas.152112399"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_025","doi-asserted-by":"crossref","unstructured":"Gulyaeva, NV. Functional neurochemistry of the ventral and dorsal hippocampus: stress, depression, dementia and remote hippocampal damage. Neurochem Res 2019;44:1306\u201322. https:\/\/doi.org\/10.1007\/s11064-018-2662-0.","DOI":"10.1007\/s11064-018-2662-0"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_026","doi-asserted-by":"crossref","unstructured":"Strange, BA, Witter, MP, Lein, ES, Moser, EI. Functional organization of the hippocampal longitudinal axis. Nat Rev Neurosci 2014;15:655\u201369. https:\/\/doi.org\/10.1038\/nrn3785.","DOI":"10.1038\/nrn3785"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_027","doi-asserted-by":"crossref","unstructured":"Felix-Ortiz, AC, Beyeler, A, Seo, C, Leppla, CA, Wildes, CP, Tye, KM. BLA to vHPC inputs modulate anxiety-related behaviors. Neuron 2013;79:658\u201364. https:\/\/doi.org\/10.1016\/j.neuron.2013.06.016.","DOI":"10.1016\/j.neuron.2013.06.016"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_028","doi-asserted-by":"crossref","unstructured":"Felix-Ortiz, AC, Tye, KM. Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci 2014;34:586\u201395. https:\/\/doi.org\/10.1523\/jneurosci.4257-13.2014.","DOI":"10.1523\/JNEUROSCI.4257-13.2014"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_029","unstructured":"Paxinos, G, Franklin, KB. The mouse brain in stereotaxic coordinates. San Diego: Academic Press; 2008."},{"key":"2026101305050410305_j_jcim-2021-0159_ref_030","doi-asserted-by":"crossref","unstructured":"Corn\u00e9lio, AM, Nunes-de-Souza, RL. Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze. Behav Brain Res 2007;178:82\u20139. https:\/\/doi.org\/10.1016\/j.bbr.2006.12.003.","DOI":"10.1016\/j.bbr.2006.12.003"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_031","doi-asserted-by":"crossref","unstructured":"Zhu, S, Shi, R, Wang, J, Wang, JF, Li, XM. Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice. Neuroreport 2014;25:1151\u20135. https:\/\/doi.org\/10.1097\/wnr.0000000000000243.","DOI":"10.1097\/WNR.0000000000000243"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_032","doi-asserted-by":"crossref","unstructured":"McEwen, BS, Magarinos, AM. Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders. Hum Psychopharmacol 2001;16:7\u201319. https:\/\/doi.org\/10.1002\/hup.266.","DOI":"10.1002\/hup.266"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_033","doi-asserted-by":"crossref","unstructured":"Chiba, S, Numakawa, T, Ninomiya, M, Richards, MC, Wakabayashi, C, Kunugi, H. Chronic restraint stress causes anxiety-and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuro-Psychopharmacol Biol Psychiatry 2012;39:112\u20139. https:\/\/doi.org\/10.1016\/j.pnpbp.2012.05.018.","DOI":"10.1016\/j.pnpbp.2012.05.018"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_034","doi-asserted-by":"crossref","unstructured":"Masneuf, S, Lowery-Gionta, E, Colacicco, G, Pleil, KE, Li, C, Crowley, N, et al.. Glutamatergic mechanisms associated with stress-induced amygdala excitability and anxiety-related behavior. Neuropharmacology 2014;85:190\u20137. https:\/\/doi.org\/10.1016\/j.neuropharm.2014.04.015.","DOI":"10.1016\/j.neuropharm.2014.04.015"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_035","doi-asserted-by":"crossref","unstructured":"Meng, FT, Zhao, J, Fang, H, Liu, YJ. The influence of chronic stress on anxiety-like behavior and cognitive function in different human GFAP-ApoE transgenic adult male mice. Stress 2015;18:419\u201326. https:\/\/doi.org\/10.3109\/10253890.2015.1040986.","DOI":"10.3109\/10253890.2015.1040986"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_036","unstructured":"Samkhaniani, E, Nodehei, D, Salem, F, Zarghami, MH, Khosravi, M, Hatef, B, et al.. NMDA glutamate receptor inhibition in the dorsal hippocampus reduced the maintenance of electric foot shock stress-induced anxiety and depression like behaviors in mice. Koomesh 2019;21:716\u201325."},{"key":"2026101305050410305_j_jcim-2021-0159_ref_037","doi-asserted-by":"crossref","unstructured":"Mathew, SJ, Coplan, JD, Smith, EL, Schoepp, DD, Rosenblum, LA, Gorman, JM. Glutamate\u2014hypothalamic-pituitary-adrenal axis interactions: implications for mood and anxiety disorders. CNS Spectr 2001;6:555\u201364. https:\/\/doi.org\/10.1017\/s1092852900002091.","DOI":"10.1017\/S1092852900002091"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_038","doi-asserted-by":"crossref","unstructured":"Christian, KM, Miracle, AD, Wellman, CL, Nakazawa, K. Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors. Neuroscience 2011;17:26\u201336. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.11.033.","DOI":"10.1016\/j.neuroscience.2010.11.033"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_039","doi-asserted-by":"crossref","unstructured":"Dorey, R, Pi\u00e9rard, C, Chauveau, F, David, V, B\u00e9racoch\u00e9a, D. Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus. Neuropsychopharmacology 2012;37:2870\u201380. https:\/\/doi.org\/10.1038\/npp.2012.170.","DOI":"10.1038\/npp.2012.170"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_040","doi-asserted-by":"crossref","unstructured":"Luine, V, Villegas, M, Martinez, C, McEwen, BS. Repeated stress causes reversible impairments of spatial memory performance. Brain Res 1994;639:167\u201370. https:\/\/doi.org\/10.1016\/0006-8993(94)91778-7.","DOI":"10.1016\/0006-8993(94)91778-7"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_041","doi-asserted-by":"crossref","unstructured":"Luine, V, Martinez, C, Villegas, M, Magari\u00f1os, AM, McEwen, BS. Restraint stress reversibly enhances spatial memory performance. Physiol Behav 1996;59:27\u201332. https:\/\/doi.org\/10.1016\/0031-9384(95)02016-0.","DOI":"10.1016\/0031-9384(95)02016-0"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_042","doi-asserted-by":"crossref","unstructured":"Autry, AE, Adachi, M, Nosyreva, E, Na, ES, Los, MF, Cheng, PF, et al.. NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 2011;475:91\u20135. https:\/\/doi.org\/10.1038\/nature10130.","DOI":"10.1038\/nature10130"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_043","doi-asserted-by":"crossref","unstructured":"Michaelis, EK. Molecular biology of glutamate receptors in the\u00a0central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog Neurobiol 1994;54:369\u2013415. https:\/\/doi.org\/10.1016\/s0301-0082(97)00055-5.","DOI":"10.1016\/S0301-0082(97)00055-5"},{"key":"2026101305050410305_j_jcim-2021-0159_ref_044","doi-asserted-by":"crossref","unstructured":"Sanacora, G, Zarate, CA, Krystal, JH, Manji, HK. Targeting the glutamatergic system to develop novel, improved therapeutics\u00a0for mood disorders. Nat Rev Drug Discov 2008;7:426\u201337. https:\/\/doi.org\/10.1038\/nrd2462.","DOI":"10.1038\/nrd2462"}],"container-title":["Journal of Complementary and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2021-0159\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2021-0159\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:05:13Z","timestamp":1791867913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jcim-2021-0159\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,9,16]]},"published-print":{"date-parts":[[2022,9,30]]}},"alternative-id":["10.1515\/jcim-2021-0159"],"URL":"https:\/\/doi.org\/10.1515\/jcim-2021-0159","relation":{},"ISSN":["1553-3840"],"issn-type":[{"value":"1553-3840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]}}}