{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:45:52Z","timestamp":1791870352331,"version":"4.3.4"},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2021-0482_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Lead exposure seriously impairs male reproductive function. The protective capacity of\n                      <jats:italic>Pedalium murex<\/jats:italic>\n                      leafy stem and fruit aqueous extracts against lead testicular toxicity is evaluated to find herbals drugs able to improve semen quality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2021-0482_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Phytochemical screening were performed according to classical methods. Twenty four male rats were divided into four groups of six rats each and received the following treatments via oral route: distilled water; 0.2% lead acetate in drinking water; 0.2% lead acetate in drinking water with 400\u00a0mg\/kg\n                      <jats:italic>P.\u00a0murex<\/jats:italic>\n                      aqueous leafy stem extract; 0.2% leaded water with 400\u00a0mg\/kg\n                      <jats:italic>P.\u00a0murex<\/jats:italic>\n                      aqueous fruit extract. Treatments were administered for 70\u00a0days. Body and reproductive organs weights, sperm parameters and testicular histological sections of each group were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2021-0482_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Flavonoids, tannins, coumarins, alkaloids, and lignans were found in both extracts. Lead intoxication reduced sperm motility and count but increased the percentage of morphologically abnormal sperms. The\u00a0germinal epithelium of seminiferous tubules histoarchitecture was disorganized by lead. The leafy stem extract was effective in reducing lead induced testicular disruption whereas fruit has not shown any beneficial effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2021-0482_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P.\u00a0murex<\/jats:italic>\n                      leafy stem aqueous extract is effective against semen alterations caused by lead.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2021-0482","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T10:35:27Z","timestamp":1641897327000},"page":"683-690","source":"Crossref","is-referenced-by-count":7,"title":["Aqueous extract of\n                    <i>Pedalium murex<\/i>\n                    D. Royen ex L\n                    <i>.<\/i>\n                    leafy stem protects against lead induced testicular toxicity in Wistar rats"],"prefix":"10.1515","volume":"19","author":[{"given":"Gerard Bessan","family":"Dossou-Agoin","sequence":"first","affiliation":[{"name":"Experimental Physiology and Pharmacology Laboratory , Faculty of Sciences and Technology, University of Abomey-Calavi , Cotonou Benin , Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Gbankoto","sequence":"additional","affiliation":[{"name":"Experimental Physiology and Pharmacology Laboratory , Faculty of Sciences and Technology, University of Abomey-Calavi , Cotonou Benin , Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Azonbakin","sequence":"additional","affiliation":[{"name":"Histology, Biology of Reproduction, Cytogenetics and Medical Genetics Laboratory , Faculty of Health Sciences, University of Abomey-Calavi , Cotonou Benin , Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razack","family":"Osseni","sequence":"additional","affiliation":[{"name":"Unit of Physiology , Faculty of Health Sciences, University of Abomey Calavi , Cotonou Benin , Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Yemoa","sequence":"additional","affiliation":[{"name":"Analytical Chemistry and Drug Analysis Laboratory , Faculty of Health Sciences, University of Abomey Calavi , Cotonou Benin , Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatole","family":"Lal\u00e8y\u00e8","sequence":"additional","affiliation":[{"name":"Histology, Biology of Reproduction, Cytogenetics and Medical Genetics Laboratory , Faculty of Health Sciences, University of Abomey-Calavi , Cotonou Benin , Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"2026101305041339674_j_jcim-2021-0482_ref_001","doi-asserted-by":"crossref","unstructured":"Carlsen, E, Giwercman, A, Keiding, N, Skakkebaek, NE. 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