{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:20:11Z","timestamp":1787728811111,"version":"build-2784847793"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2023-0168_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The hepatoprotective properties of scopoletin have been explored in carbon tetrachloride (CCl4) induced liver injury but not in drug-induced liver injury (DILI) scenarios. Only N-acetyl-cysteine (NAC) has proven efficacy in DILI treatment. Accordingly, we conducted a study to\u00a0assess the hepatoprotective action of scopoletin in the anti-tubercular treatment (ATT)-DILI model in Wistar rats, if\u00a0any.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2023-0168_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 36 rats were evaluated, with six in each group. A 36-day ATT at 100\u202fmg\/kg dose for isoniazid, 300\u202fmg\/kg for rifampicin and 700\u202fmg\/kg for pyrazinamide were fed to induce hepatotoxicity in rats. Group I and II\u2013VI received normal saline and ATT, respectively. Oral scopoletin (1,5 and 10\u202fmg\/kg) and NAC 150\u202fmg\/kg were administered in groups III, IV, V and VI, respectively, once daily for the last\u00a015\u00a0days of the experiment. LFT monitoring was performed at baseline, days 21, 28, and 36. Rats were sacrificed for the histopathology examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2023-0168_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin levels were significantly increased in group II (receiving ATT) compared to normal control on day 28 and day 36 (p&lt;0.05). All three doses of scopoletin and NAC groups led to the resolution of AST, ALT, ALP, and bilirubin changes induced by ATT medications effect beginning by day 28 and persisting on day 36 (p&lt;0.01). An insignificant effect was observed on albumin and total protein levels. The effect was confirmed with antioxidants and histopathology analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2023-0168_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study confirms the hepatoprotective efficacy of scopoletin in a more robust commonly encountered liver injury etiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2023-0168","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:41:52Z","timestamp":1695274912000},"page":"797-803","source":"Crossref","is-referenced-by-count":6,"title":["Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats"],"prefix":"10.1515","volume":"20","author":[{"given":"Swati","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Hepatology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Alka bhatia","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-2796","authenticated-orcid":false,"given":"Amol N.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibyajyoti","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Biotechnology , Postgraduate Institute of Medical Education and Research (PGIMER) , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"2025121209111692855_j_jcim-2023-0168_ref_001","doi-asserted-by":"crossref","unstructured":"Devarbhavi, H. 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