{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:12:36Z","timestamp":1771650756015,"version":"3.50.1"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jcim-2023-0290_abs_001\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to examine the potential protective effects of Iraqi\u00a0<jats:italic>H. tiliaceus L<\/jats:italic>. chloroform leaves extract on DEN-induced HCC in male Wistar Albino rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jcim-2023-0290_abs_002\">\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Rats were assigned to four groups, six in each group. Group I: rats were administered a daily oral dose of 1\u202fmL\/kg\/day of distilled water. Group II: rats were intraperitoneally injected with 70\u202fmg\/kg DEN once per week for 10 consecutive weeks. Group III: rats received 250\u202fmg\/kg of chloroform leaves extract. Groups IV: the rats were administered 500\u202fmg\/kg of chloroform leaves extract, along with their food, for five days per week over 20\u00a0weeks, with a subsequent dose of DEN once per week for 10 consecutive weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jcim-2023-0290_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The results indicate that the extract demonstrated a significant reduction (p&lt;0.05) in oxidative stress, pro-inflammatory mediators, and HCC parameters, the extract also had a beneficial effect on liver function tests, and there was a significant elevation (p&lt;0.05) of antioxidant parameters in a dose-dependent manner.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jcim-2023-0290_abs_004\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study supports the protective properties of the chloroform extract of Iraqi <jats:italic>H.\u00a0tiliaceus L<\/jats:italic>. leaves in HCC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jcim-2023-0290","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T16:10:28Z","timestamp":1705594228000},"source":"Crossref","is-referenced-by-count":1,"title":["Possible protective anticancer effect of chloroform fraction of Iraqi <i>Hibiscus tiliaceus L.<\/i> leaves extract on diethylnitrosamine-induced hepatocarcinogenesis in male rats"],"prefix":"10.1515","volume":"0","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2024-4082","authenticated-orcid":false,"given":"Zahraa Maan","family":"Abdul-Azeez","sequence":"first","affiliation":[{"name":"Medicolegal Directorate , Ministry of Health and Environment , Baghdad , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihab Hattab","family":"Mutlag","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy , University of Baghdad , Baghdad , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"2024011816102301872_j_jcim-2023-0290_ref_001","doi-asserted-by":"crossref","unstructured":"Ahmad, HA, Kathem, SH. 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