{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:31:07Z","timestamp":1767652267450,"version":"3.48.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2024-0077_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Halimeda macroloba (H. macroloba)<\/jats:italic>\n                      a seaweed commonly known as green macroalgae is a potential source of bioactive compounds utilised in nutraceuticals and pharmaceuticals. However, there are no reliable scientific studies that describe harmful consequences, which attest to its safety. Thus, the current investigation focuses on a 14-day acute toxicity assessment of\n                      <jats:italic>H.\u00a0macroloba<\/jats:italic>\n                      hydroalcoholic extract (HME).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0077_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HME was prepared using 70\u202f% alcohol as solvent by the maceration method for 72\u202fh and Soxhlet method. Phytochemical analysis was done using standard procedures, according to OECD 423 guidelines. Female Wistar albino rats fasted overnight and received a single oral dosage of 50, 300, and 2,000\u202fmg\/kg BW (body weight). Further rats were starved for 4\u202fh and watched individually for every 30\u00a0minutes, then twice a day for 14\u00a0days. To determine the toxicity overall behaviour, BW, haematological, biochemical, histopathology, and gross morphology were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0077_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pharmacologically active phytoconstituents were identified by phytochemical analysis. No significant abnormalities\/fatalities from single-dose of HME at escalating doses. No BW or behavioural changes. The majority of the haematological and biochemical parameters were normal. Did not show any apparent changes. simultaneously, a few indicated slight variations that may or may not be caused by HME extract no lesions or anomalies in Gross morphology. Histopathological investigations revealed that HME had no adverse effects on organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0077_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HME administration at doses up to 2,000\u202fmg\/kg BW didn\u2019t result in acute toxicity\/impairment to the pancreas, liver or kidney. Nevertheless, the study\u2019s limited test dose of 2,000\u202fmg\/kg, BW, didn\u2019t result in any fatalities\/ adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2024-0077","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T04:41:36Z","timestamp":1725424896000},"page":"511-519","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical analysis and acute toxicity study of seaweed\n                    <i>Halimeda macroloba<\/i>\n                    using Wistar albino rats"],"prefix":"10.1515","volume":"21","author":[{"given":"Kavya","family":"Rangaraj","sequence":"first","affiliation":[{"name":"Mahatma Gandhi Medical College and Research Institute , Sri Balaji Vidyapeeth , Pillaiyarkuppam , Puducherry , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vimala","family":"Ananthy","sequence":"additional","affiliation":[{"name":"Mahatma Gandhi Medical College and Research Institute , Sri Balaji Vidyapeeth , Pillaiyarkuppam , Puducherry , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Singam","sequence":"additional","affiliation":[{"name":"Vasantrao Naik Shaskiya Vaidyakia Mahavidyalay , Yavatmal , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartik J.","family":"Salwe","sequence":"additional","affiliation":[{"name":"Mahatma Gandhi Medical College and Research Institute , Sri Balaji Vidyapeeth , Pillaiyarkuppam , Puducherry , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumarappan","family":"Manimekalai","sequence":"additional","affiliation":[{"name":"Mahatma Gandhi Medical College and Research Institute , Sri Balaji Vidyapeeth , Pillaiyarkuppam , Puducherry , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmuga","family":"Samy","sequence":"additional","affiliation":[{"name":"Mahatma Gandhi Medical College and Research Institute , Sri Balaji Vidyapeeth , Pillaiyarkuppam , Puducherry , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shravan","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Jipmer , Puducherry , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"2025121209043054252_j_jcim-2024-0077_ref_001","doi-asserted-by":"crossref","unstructured":"Parasuraman, S. 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