{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:40:41Z","timestamp":1791524441543,"version":"4.3.4"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2024-0133_abs_001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The present study was aimed at investigating the antinociceptive and anti-inflammatory activities of the solvent fractions of the roots of\u00a0\n                      <jats:italic>Echinops kebericho<\/jats:italic>\n                      \u00a0Mesfin in rodent models of pain and inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0133_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Successive maceration was used as a method of extraction using solvents of increasing polarity: methanol and water. Ethyl acetate, chloroform and distilled water were used as solvents of the fraction process. Swiss albino mice models were used in acetic acid induced writhing, hot plate, carrageenan induced paw edema and cotton pellet granuloma to assess the analgesic and anti-inflammatory activities. The test groups received different doses (100\u202fmg\/kg, 200\u202fmg\/kg and 400\u202fmg\/kg) of the three fractions (chloroform, ethyl acetate and aqueous). The positive control groups received ASA (150\u202fmg\/kg) for the writing test, morphine (10\u202fmg\/kg) for the hot plate method, diclofenac Na for carrageenan-induced paw edema, and dexamethasone (10\u202fmg\/kg) for granuloma, while the negative control group received distilled water.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0133_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EA fraction at all test doses employed (100\u202fmg\/kg, 200\u202fmg\/kg, and 400\u202fmg\/kg) showed statistically significant (p&lt;0.05, p&lt;0.01, p&lt;0.001 respectively) analgesic and anti-inflammatory activities in a dose-dependent manner. The AQ fraction on the other hand produced statistically significant (p&lt;0.05, p&lt;0.012) analgesic and anti-inflammatory activities at the doses of 200\u202fmg\/kg and 400\u202fmg\/kg, while the CH fraction exhibited statistically significant (p&lt;0.05) analgesic and anti-inflammatory activity at the dose of 400\u202fmg\/kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0133_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In general, the data obtained from the present study elucidated that the solvent fractions of the study plant possessed significant analgesic and anti-inflammatory activities and were recommended for further investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2024-0133","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T03:25:46Z","timestamp":1718681146000},"page":"314-324","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of anti-nociceptive and anti-inflammatory activities of solvent fraction of the roots of\n                    <i>Echinops kebericho<\/i>\n                    Mesfin (Asteraceae) in mice model"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-7120","authenticated-orcid":false,"given":"Tesfaye Yimer","family":"Tadesse","sequence":"first","affiliation":[{"name":"Department of Pharmacy , Health Science College, Debre Tabor University , Debre Tabor , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Berihun Dagnew","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Health Science College, Debre Tabor University , Debre Tabor , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfagegn","family":"Gobezie Yiblet","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Health Science College, Debre Tabor University , Debre Tabor , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getu","family":"Tesfaw Addis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy , Health Science College, Debre Tabor University , Debre Tabor , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemene Demelash","family":"Kiflie","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , School of Pharmacy, College of Medicine and Health Science, University of Gondar , Gondar , Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"2026040704084166271_j_jcim-2024-0133_ref_001","doi-asserted-by":"crossref","unstructured":"Stanton-Hicks, M, J\u00e4nig, W, Hassenbusch, S, Haddox, JD, Boas, R, Wilson, P. 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